Time to Detection of Yeast Isolates in Pediatric and Adult Patients with Fungemia and its Relevance to Clinical Profile and Outcome

Butta, Hena; Sardana, Raman; Mendiratta, Leena; Sibal, Anupam; Gupta, Vidya S.; Chawla, Rajesh; Jafri, Ali Ammar

doi:10.5005/jp-journals-10071-23108

Cited by 4 publications

(7 citation statements)

References 16 publications

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“…Study conducted by Park et al reported mean TTP of C. glabrata, C. albicans, C. parapsilosis and C. tropicalis to be 50.8 hrs, 37.5 hrs, 35.3 hrs and 22.4 hrs respectively ( 21 ). Study conducted in India by Butta et al also reported that TTP of C. tropicalis and C. glabrata was found to be significantly shorter and longer respectively when compared to other isolates ( 22 ). The findings in our study as well as those in other studies suggest that while TTP differs among different species of Candida , shorter TTP may be predictive of candidemia caused by C. tropicalis and longer TTP maybe predictive of candidemia caused by C. glabrata.…”

Section: Discussionmentioning

confidence: 98%

Time to positivity of blood cultures causing candidemia and its relation to mortality

Sachu,

Sunny,

Mathew

et al. 2024

IJM

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Background and Objectives: Early diagnosis of candidemia is of vital importance in reducing mortality and morbidity. The main objective of the study was to determine the TTP (Time to Positivity) of different species of Candida causing blood- stream infection and to see whether TTP can help differentiate Candida glabrata which is frequently fluconazole resistant from Fluconazole sensitive Candida. Materials and Methods: TTP (Time to positivity) and AAT (Appropriate Antifungal therapy) were noted for Blood cultures becoming positive for Candida. Presence of Risk factors for candidemia like prolonged ICU stay, neutropenia, Total Paren- teral Nutrition (TPN), use of steroids , broad spectrum antibiotics, use of Central Venous Catheter, Foleys catheter were also analyzed. Results: The most frequent isolates were Candida parapsilosis, Candida tropicalis and Candida albicans. The median TTP for all Candida isolates in our study was 34 hours. The diagnostic sensitivity of TTP for detecting C. glabrata and C. tropicalis in patients with candidemia was 88% and 85% respectively. TTP showed that there was no difference in survival between TTP <24 hrs. and > 24hrs. Initiation of antifungal therapy <24 hours and > 24hrs after onset of candidemia had no association with survival. Conclusion: Longer TTP maybe predictive of C. glabrata while shorter TTP may be predictive of C. tropicalis. In our study we found that fluconazole resistant Candida causing blood stream infection is quite unlikely if the TTP of the isolate is <48hrs.

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Section: Discussionmentioning

confidence: 98%

Time to positivity of blood cultures causing candidemia and its relation to mortality

Sachu,

Sunny,

Mathew

et al. 2024

IJM

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“…might also cause IFIs (Kotey et al, 2021). Early detection and treatment have proven to have crucial role for prognosis, especially in guidance of antifungal stewardship committees (Butta et al, 2019;Dudakova, 2022). However, indirect diagnostic procedures (serology, etc.)…”

Section: Discussionmentioning

confidence: 99%

Can Blood Culture Contaminaton Cloud Fungal Positivity?

et al. 2023

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Objective: Blood culture (BC) is gold standard for diagnosis of fungemia. Contamination of BC is a major problem worldwide, since it may delay actual diagnosis. The aim of this study was to evaluate “contaminant” vials with a prolonged incubation (max 30 days) with antimicrobial supplemented media to observe any mycological growth. Materials and Methods: Routine BCs optained patients of XXX Hospital for a year period were included. Render BC System BC12-8 (Render Biotech Co. Ltd., Shenzhen, China) were used. Contaminated vials were reincubated and conventionally-inoculated weekly for four weeks total. In case of any growth, identifications were done by PhoenixTM 100 system (Becton Dickinson, MA, USA) with cornmeal tween 80 agar (RTA Laboratories, Kocaeli, Turkey). Antifungal susceptibility testing were applied with CLSI disk diffusion method. Results: 3.9% (235 sets and additional 138 vials) of total 6047 BC sets were contaminated. Only one vial from central venous catheter showed fungal growth within the first week of conventional inoculation (>8th day of total incubation). The isolate was identified as Candida guilliermondii complex and susceptible to caspofungin. Latter set of this patient were positive in the 3rd day of incubation. Conclusion: International guidelines recommend

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“…In turn, in single-center Swedish studies, C. albicans constituted as much as 65.0% of isolated Candida fungi [29]. However, the participation of individual species may vary depending on the patient group and institution [5,9,30,31].…”

Section: Discussionmentioning

confidence: 99%

Etiology of candidemia in patients with solid tumors - 7 years of experience of one oncology center

Szymankiewicz¹,

Nowikiewicz²

2021

neo

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Although the candidemia still remains a serious health problem, the study of candidemia in cancer patients is limited. We conducted a retrospective analysis of candidemia among 31 adult patients hospitalized in one oncological center. The mean annual incidence of candidemia was 0.14 ± 0.05 / 1000 patient-days (range 0.04-0.91). In 10 patients (32.3%), the catheter-related infection was diagnosed; in the remaining 21 patients (67.7%), it was a secondary infection. From 31 patients of candidemia, 15 died (48.4% 30-day mortality), but an overall mortality rate during hospital stay was 61.3% (19 cases). Patients with secondary candidemia, ASA = IV and complicated postoperative course, had poorer 1-year survival probability compared with patients with catheter-related infection (p = 0.004), ASA < IV (p = 0.0393) and uncomplicated postoperative course (p = 0.0009). C. glabrata (n = 13, 41.9%) was the most frequently isolated species, followed by C. albicans (n = 12, 38.7%) and C. parapsilosis (n= 3, 9.7%). C. lusitaniae (n = 2, 6.5%), and C. tropicalis (n = 1, 3.2%) were sporadically isolated. Within C. glabrata, there was no resistance to anidulafungin, two strains (15.4%) were resistant to fluconazole, while the othe rs showed intermediate susceptibilities to this drug. A total of 58.0% of all Candida spp. strains were sensitive to fluconazole, and 90.0% of the strains were sensitive to anidulafungin. Mortality in candidemia among patients with solid tumors undergoing surgery remains high. The complicated postoperative course requiring reoperation and secondary origin of candidemia are factors for poor prognosis. The demonstrated dominant role of C. glabrata in inducing candidemia is becoming a serious clinical and therapeutic problem. Key words: candidemia; solid tumors; mortality; etiologic agents; sensitivity to antimycotics The increasing incidence of candidemia among cancer patients and poor prognosis encourages the undertaking of research on the current etiological agents of candidemia. While there are quite numerous reports of candidemia among patients with hematological cancers, there are few publications dealing with this problem among patients with solid tumors [1-3].

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Time to Detection of Yeast Isolates in Pediatric and Adult Patients with Fungemia and its Relevance to Clinical Profile and Outcome

Cited by 4 publications

References 16 publications

Time to positivity of blood cultures causing candidemia and its relation to mortality

Time to positivity of blood cultures causing candidemia and its relation to mortality

Can Blood Culture Contaminaton Cloud Fungal Positivity?

Etiology of candidemia in patients with solid tumors - 7 years of experience of one oncology center

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