Time to electroencephalography is independently associated with outcome in critically ill neonates and children

Abstract

Both presence of electrographic SE and time from ICU admission to cEEG initiation were independent factors associated with mortality in neonates and pediatric patients with cEEG in the ICU.

The essence of the first 2.5 h in the treatment of generalized convulsive status epilepticus

“…Focal SE is associated with longer diagnostic delays [10], as is also electrographic SE, whereby availability of EEG is essential for diagnosis. In a paediatric material, delay of cEEG in electrographic SE was associated with increased mortality [39]. Our results agree with earlier knowledge by showing that long diagnostic delay is associated with low GOS score at discharge.…”

Development of a model to predict electroencephalographic seizures in critically ill children

“…6,7,[11][12][13]17 Finally, patients with acute structural etiologies had an increased risk for ES, consistent with trends in prior studies. 7,12,14 A study in which only 50% of subjects had an acute structural disorder reported an ES incidence of ES 9%, 4 whereas studies in which the majority of subjects had structural disorders reported ES incidence ranges from 20%-40%, 2,[6][7][8]10,12,13,15,16,19,[28][29][30] and studies in which all subjects had an acute structural disorder reported ES incidence ranges from 40%-60%. 5,14,17,[25][26][27] In critically ill adults, the severity of mental status depression is predictive of ES.…”

“…Electroencephalographic seizures (ESs) are reported in 10%‐40% of children with acute encephalopathy who undergo continuous electroencephalography (EEG) (CEEG) monitoring, and identification requires CEEG because most ESs cannot be identified by clinical observation alone . Increasing evidence indicates that high ES burdens are associated with unfavorable neurobehavioral outcomes .…”

Predicting the Outcome of Critically Ill Children and Adolescents with Electroencephalography

“…The etiologies for PICU admission were categorized into one of the following: (1) HIE diagnosed by computed tomography or magnetic resonance imaging (MRI); (2) non-HIE structural brain disease such as encephalitis or other structural brain damage; (3) functional or non-structural brain dysfunction with no evident brain damage shown on MRI, but with a possible source of brain malfunction such as hypoxic, metabolic, toxic, or infectious etiologies; and (4) others indicating non-central nervous system (CNS) dysfunction [5].…”

“…Electroencephalography (EEG), a non-invasive, bedside investigative tool reflecting cortical activities and dysfunction that can be readily applied to both adult and pediatric patients in intensive care units (ICUs), is also well known to have prognostic significance in critically ill patients in several studies [3][4][5][6]. EEG is a sensitive tool to detect encephalopathies, and patients with neurologic complications were shown to have an increased risk of mortality compared with patients who do not exhibit these problems [7].…”