Time to Include Fine Specificity Anti‐Citrullinated Protein Antibodies in the Routine Diagnosis and Management of Rheumatoid Arthritis?

Schwenzer, Anja; Quirke, Anne Marie; Montgomery, Anna B.; Venables, P. J. W.; Sayles, Harlan; Schlumberger, Wolfgang; Payne, Jeffrey B.; Mikuls, Ted R.; Midwood, Kim S.

doi:10.1002/art.40767

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Testing for inflammatory markers, such as elevated erythrocyte sedimentation rate, C-reactive protein, antinuclear antibody, and human leukocyte antigen B27, may aid in ruling out systemic inflammatory diseases, such as rheumatoid arthritis, lupus, or seronegative spondyloarthropathies 15,16. Rheumatoid factor and anticyclic citrullinated peptides provide indication for rheumatoid arthritis 17,18…”

Section: Presentation and Diagnosismentioning

confidence: 99%

“…15,16 Rheumatoid factor and anticyclic citrullinated peptides provide indication for rheumatoid arthritis. 17,18 Imaging studies for SIJ dysfunction may provide value in ruling out other causes of low back pain; however, diagnosing SIJ dysfunction based on imaging alone is neither sensitive nor specific. 4 The SIJ is difficult to visualize on x-ray and typically results in equivocal findings in patients with suspected SIJ dysfunction.…”

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confidence: 99%

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Presentation, Diagnosis, and Treatment of Sacroiliac Joint Dysfunction

Anwar,

Nie,

Hartman

et al. 2023

Contemporary Spine Surgery

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Section: Presentation and Diagnosismentioning

confidence: 99%

mentioning

confidence: 99%

Presentation, Diagnosis, and Treatment of Sacroiliac Joint Dysfunction

Anwar,

Nie,

Hartman

et al. 2023

Contemporary Spine Surgery

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Polymorphic Analysis of Genes PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175) in Arthritis Patients in Pakistani Population

Bashir,

Chaudhary,

Aslam

et al. 2023

Biochem Genet

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Gene are an important factor for the initiation of any disease which has a family history. Many genes are associated with RA other than environmental factors. The main objective of the study was to evaluate the association of genes PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175) polymorphisms in RA patients from population of Punjab, Pakistan. Blood samples of RA patients were collected from different hospitals of Sargodha. DNA was extracted, followed by PCR. Polymorphic analysis was performed in 300 rheumatoid arthritis patients and 300 healthy controls. PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175). In PADI4 gene, both homozygous mutant genotype (TT) and heterozygous (CT) of SNP rs2240340 showed signi cant association by increasing the risk of RA upto 2 folds (OR = 2.55; 95% CI = 1.57-4.15; p = 0.0002). In case of rs1748033 polymorphism, homozygous mutant genotype (TT) showed signi cant association with RA with increasing risk of disease up to 3-folds (OR = 3.46; 95% CI = 1.97-6.07; p = 0.0001), while heterozygous genotype (CT) of the same SNP showed signi cant association with RA by playing a protective role (OR = 0.57; 95% CI = 0.36-0.91; p = 0.0197). In HLA-DRB1 gene, homozygous mutant genotype (GG) of SNP rs2395175 showed no signi cant association with RA, while heterozygous genotype (AG) of the same SNP showed signi cant association with RA by playing a protective role (OR = 0.44; 95% CI = 0.27-0.71; p = 0.0009).Conclusions: Highly signi cance association of genes PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175) polymorphisms with RA was observed in Pakistani population.

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Autoimmunity in 2019

Selmi

2020

Clinic Rev Allerg Immunol

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Time to Include Fine Specificity Anti‐Citrullinated Protein Antibodies in the Routine Diagnosis and Management of Rheumatoid Arthritis?

Cited by 4 publications

References 10 publications

Presentation, Diagnosis, and Treatment of Sacroiliac Joint Dysfunction

Presentation, Diagnosis, and Treatment of Sacroiliac Joint Dysfunction

Polymorphic Analysis of Genes PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175) in Arthritis Patients in Pakistani Population

Autoimmunity in 2019

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