Time to positivity in blood cultures of adults with nontyphoidal Salmonella bacteremia

Lin, Hui-Wen; Hsu, Hsin-Sui; Huang, Yu-Tsung; Yang, Chia‐Jui; Hsu, Meng-Shiuan; Liao, Chun-Hsing

doi:10.1016/j.jmii.2014.08.004

Cited by 14 publications

(11 citation statements)

References 28 publications

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“…Although blood culture was negative for Salmonella sp. in our case, positive blood culture results have been reported in up to 30% of patients with Salmonella osteomyelitis [8].…”

Section: Discussionsupporting

confidence: 56%

A Case Report of Salmonella Typhi Osteomyelitis With Pathological Fracture in an Immunocompetent Adult

Venkataram

Muthulingam

2020

Cureus

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“…Although blood culture was negative for Salmonella sp. in our case, positive blood culture results have been reported in up to 30% of patients with Salmonella osteomyelitis [8].…”

Section: Discussionsupporting

confidence: 56%

A Case Report of Salmonella Typhi Osteomyelitis With Pathological Fracture in an Immunocompetent Adult

Venkataram

Muthulingam

2020

Cureus

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“…When screening the citations of the 80 studies, we identified an additional four studies that met our inclusion criteria, yielding a total of 84 eligible studies for analysis ( figure 1 ). 6 , 15 , 16 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 ,…”

Section: Resultsmentioning

confidence: 99%

“…Consequently, anaemia might be over-reported as a complication of non-typhoidal salmonella invasive disease in our study, since we were unable to ascertain whether it was present before the onset of non-typhoidal salmonella invasive disease. As a result, it was difficult to be confident that author-reported complications met the widely accepted definitions of clinical conditions, and to ascertain whether some clinical observations were actual Taoyuan, Taiwan, 1990 68 Kaohsiung, Taiwan, 2002 62 Taoyuan, Taiwan, 2003 104 Taipei, Taiwan, 2003 111 Taipei, Taiwan, 2004 60 Taipei, Taiwan, 2004 110 Tainan, Taiwan, 2005 43 Taipei, Taiwan, 2006 63 Taipei, Taiwan, 2006 112 Tainan, Taiwan, 2009 72 New Taipei City, Taiwan, 2012 73 Taipei and New Taipei City, Taiwan, 2014 45 Taipei, Taiwan, 2015 44…”

Section: Western Africamentioning

confidence: 99%

Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis

Marchello

Birkhold

Crump

2022

The Lancet Infectious Diseases

113

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Background Non-typhoidal salmonella can cause serious, life-threatening invasive infections involving the bloodstream and other normally sterile sites. We aimed to systematically review the prevalence of complications and case-fatality ratio (CFR) of non-typhoidal salmonella invasive disease to provide contemporary global estimates and inform the development of vaccine and non-vaccine interventions. MethodsWe did a global systematic review and meta-analysis of studies investigating the complications and mortality associated with non-typhoidal salmonella invasive disease. We searched Embase, MEDLINE, Web of Science, and PubMed for peer-reviewed, primary research articles published from database inception up to June 4, 2021, with no restrictions on language, country, date, or participant demographics. Only studies reporting the proportion of complications or deaths associated with non-typhoidal salmonella invasive disease, confirmed by culture of samples taken from a normally sterile site (eg, blood or bone marrow) were included. We excluded case reports, case series, policy reports, commentaries, editorials, and conference abstracts. Data on the prevalence of complications and CFR were abstracted. The primary outcomes were to estimate the prevalence of complications and CFR of non-typhoidal salmonella invasive disease. We calculated an overall pooled CFR estimate and pooled CFR stratified by UN region, subregion, age group, and by serovar when available with a random-effects meta-analysis. A risk-of-bias assessment was done, and heterogeneity was assessed with Cochran's Q Test, I², and τ². This study was done in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, and is registered with PROSPERO, CRD42020202293. FindingsThe systematic review returned a total of 8770 records. After duplicates were removed, 5837 titles and abstracts were screened, yielding 84 studies from 35 countries after exclusions. Of these included studies, 77 (91•7%) were hospital-based and 66 (78•6%) were located in Africa or Asia. Among 55 studies reporting non-typhoidal salmonella disease-associated complications, a total of 45 different complications were reported and 1824 complication events were identified among 6974 study participants. The most prevalent complication was septicaemia, occurring in 171 (57•2%) of 299 participants, followed by anaemia in 580 (47•3%) of 1225 participants. From 81 studies reporting the CFR of non-typhoidal salmonella invasive disease, the overall pooled CFR estimate was 14•7% (95% CI 12•2-17•3). When stratified by UN region, the pooled CFR was 17•1% (13•6-21•0) in Africa, 14•0% (9•4-19•4) in Asia, 9•9% (6•4-14•0) in Europe, and 9•6% (0•0-25•1) in the Americas. Of all 84 studies, 66 (78•6%) had an overall high risk of bias, 18 (21•4%) had a moderate risk, and none had a low risk. Substantial heterogeneity (I²>80%) was observed in most (15 [65•2%] of 23) CFR estimates. Interpretation Complications were frequent among individuals with non-typhoidal salmonella invasive disease ...

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“…The TTP may depend on multiple factors, including the volume of blood inoculated, the time elapse from specimen collection to incubation, and the concentration of organism within the blood [1,3,7]. In our study, we demonstrated that factors associated with TTP <24 hours were an underlying disease of malignancy, endocarditis and vascular infection, thrombocytopenia, and clinical of SIRS.…”

Section: Discussionmentioning

confidence: 58%

“…A study among patients with E. coli bacteremia also reported that rapid TTP (<7 hours) was noted in patients who had active malignancies and neutropenia [1]. In addition, a study among patients with nontyphoidal salmonella bacteremia, rapid TTP (<10 hours) was associated with endovascular lesion and higher bacteremia score [3]. However, a study among children with S. pneumoniae bacteremia, no clinical or laboratory parameters was associated with the early growth of organisms [23].…”

Section: Discussionmentioning

confidence: 99%

Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system

Krisanapan

Chaiwarith

2019

Asian Biomedicine

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Background Previous studies showed that clinically significant pathogens were detected within 3 days of incubation using a continuous monitoring automated blood culture instrument. Objectives To determine time to blood culture positivity (TTP) of microorganisms using a BD BACTEC™ FX. Methods A cross-sectional study was conducted at Maharaj Nakorn Chiang Mai Hospital, Thailand from October to November 2014. Results One-hundred and eighty-one patients with 195 episodes of infection and 436 cultures were included in the analysis. Among 181 patients, 55.2% were male and the median age was 61 years (interquartile range (IQR) 50, 76). Of the 195 episodes of infections, the most common source was genitourinary tract (15.4%). Overall, the median TTP was 17 hours (IQR 11.5, 24.5), the shortest TTP was observed in Streptococcus agalactiae. Four-hundred and seventy-eight cultures (97.6%) and all (100%) were detected at 3 days and 5 days of incubation. Factors associated with TTP ≤24 hour were blood drawn from patients who had hematologic malignancy (odds ratio (OR) 9.6, 95% confidence interval (CI) 1.2, 74.3, P = 0.030), endocarditis and vascular infection (OR 8.7, 95% CI 1.1, 67.2, P = 0.038), thrombocytopenia (OR 2.4, 95% CI 1.3, 4.4, P = 0.004), clinical of systemic inflammatory response syndrome (SIRS) (OR 2.3, 95% CI 1.2, 4.5, P = 0.014), and not receiving antimicrobials within 72 hours before cultures taken (OR 2.2, 95% CI 1.4, 3.6, P < 0.001). Conclusions TTP varied depends upon the pathogens and clinical settings. However, bacteria were isolated from almost, but not all of the blood cultures within 3 days of incubation.

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Time to positivity in blood cultures of adults with nontyphoidal Salmonella bacteremia

Abstract: The TTP of blood cultures, interpreted with a cut-off point of <10 hours, in patients with NTS bacteremia may provide useful diagnostic and prognostic information.

Cited by 14 publications

References 28 publications

A Case Report of Salmonella Typhi Osteomyelitis With Pathological Fracture in an Immunocompetent Adult

A Case Report of Salmonella Typhi Osteomyelitis With Pathological Fracture in an Immunocompetent Adult

Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis

Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system

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