Time to positivity of blood cultures in bloodstream infections with <i>Streptococcus dysgalactiae</i> and association with outcome

Bläckberg, Anna; Lundberg, Katrina; Svedevall, Stina; Nilson, Bo; Rasmussen, Magnus

doi:10.1080/23744235.2023.2182910

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…Several studies have shown that the risk of IE is low in E. faecalis bacteremia of nosocomial origin and with known focus [ 11–13 , 21 , 22 ] as well as in S. dysgalactiae bacteremia [ 19 , 23–25 ]. The study referred to in the Duke-ISCVID criteria to justify the inclusion of S. dysgalactiae as a typical IE pathogen is the only one reporting a much higher risk of IE in S. dysgalactiae bacteremia [ 4 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

Performance of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis in Relation to the Modified Duke Criteria and to Clinical Management—Reanalysis of Retrospective Bacteremia Cohorts

Lindberg,

Berge,

Jovanovic-Stjernqvist

et al. 2024

Clinical Infectious Diseases

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Background Revised diagnostic criteria for infective endocarditis (IE), the 2023 Duke-ISCVID criteria, were recently presented and need validation. Here, we compare the 2000 modified Duke criteria for IE with Duke-ISCVID among patients with bacteremia and relate the diagnostic classification to IE-treatment. Methods We reanalyzed patient cohorts with Stapylococcus aureus, Staphylococcus lugdunensis, non-beta-hemolytic streptococci, Streptococcus-like bacteria, Streptococcus dysgalactiae, Enterococcus faecalis and HACEK bacteremia. Episodes were classified as definite, possible or rejected IE with the modified Duke and Duke-ISCVID criteria. Reclassification included the microbiology criteria, PET-CT and cardiac implanted elect-ronical devices. To calculate sensitivity, patients treated as IE were considered as having IE. Results In 4050 episodes of bacteremia, the modified Duke criteria criteria assigned 307episodes (7.6%) as definite IE, 1190 episodes (29%) as possible IE and 2553 episodes (63%) as rejected IE. Using the Duke-ISCVID criteria, 13 episodes (0.3%) were reclassified from possible to definite IE and 475 episodes (12%) were reclassified from rejected to possible IE. With the modified Duke criteria, 79 episodes that were treated as IE were classified as possible IE and eleven of these episodes were reclassified to definite IE with Duke-ISCVID. Applying the decision to treat for IE as reference standard, the sensitivity of the Duke-ISCVID criteria was 80%. None of the 475 episodes reclassified to possible IE were treated as IE. Conclusions The Duke-ISCVID criteria reclassified a small proportion of episodes to definite IE at the expense of more episodes of possible IE. Future criteria should minimize the possible group while keeping or improving sensitivity.

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Section: Discussionmentioning

confidence: 99%

Performance of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis in Relation to the Modified Duke Criteria and to Clinical Management—Reanalysis of Retrospective Bacteremia Cohorts

Lindberg,

Berge,

Jovanovic-Stjernqvist

et al. 2024

Clinical Infectious Diseases

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“…The time to positivity of blood cultures for various pathogens has previously been associated with mortality, particularly in the context of S. aureus bacteremia. However, among different groups of streptococci, conflicting results have been reported [ 6 , 16 , 21 , 22 ]. In our current study, we did not find any association between the time to positivity of any streptococcal group and mortality.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Mortality of Streptococcal Bacteremia and the Role of Infectious Diseases Consultation: A Retrospective Cohort Study

Fourre,

Zimmermann,

Senn

et al. 2024

Clinical Infectious Diseases

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Background Streptococcal bacteremia is associated with high mortality. The study aims to identify predictors of mortality among patients with streptococcal bacteremia. Methods This retrospective study was conducted at the Lausanne University Hospital, Switzerland and included episodes of streptococcal bacteremia among adult patients from 2015 to 2023. Results During the study period, 861 episodes of streptococcal bacteremia were included. The majority of episodes were categorized in the Mitis group (348 episodes; 40%), followed by the Pyogenic group (215; 25%). Endocarditis was the most common source of bacteremia (164; 19%). The overall 14-day mortality rate was 8% (65 episodes). The results from the Cox multivariable regression model showed that a Charlson comorbidity index >4 (P 0.001; HR 2.87, CI 1.58-5.22), S. pyogenes (P 0.011; HR 2.54, CI 1.24-5.21), sepsis (P < 0.001; HR 7.48, CI 3.86-14.47), lower respiratory tract infection (P 0.002; HR 2.62, CI 1.42-4.81), and absence of source control interventions within 48 hours despite being warranted (P 0.002; HR 2.62, CI 1.43-4.80) were associated with 14-day mortality. Conversely, interventions performed within 48 hours of bacteremia onset, such as infectious diseases consultation (P < 0.001; HR 0.29, CI 0.17-0.48), and appropriate antimicrobial treatment (P < 0.001; HR 0.28, CI 0.14-0.57) were associated with improved outcome. Conclusions Our findings underscore the pivotal role of infectious diseases consultation in guiding antimicrobial treatment and recommending source control interventions for patients with streptococcal bacteremia.

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“…The related illnesses are mainly skin and soft tissue infections, including pyoderma, cellulitis, wound infections, abscesses, erysipelas, tonsillitis, infectious endocarditis, necrotizing fasciitis, and hematogenous complications of bacteremia. This bacterial species is susceptible to β-lactams but, to avoid delayed, poor responses or failure of antibiotic therapy, the addition of an aminoglycoside to penicillin/cephalosporins should be considered for severe infections [ 41 , 104 ]. Bloodstream infections with S. dysgalactiae , in which the subspecies equisimilis is most often involved, are frequent in the elderly and may lead to sepsis, septic shock, and complications such as symmetric peripheral gangrene, which can require limb amputation [ 101 , 105 ].…”

Section: Recent Cases Of Opportunistic Infections Transmitted By Food...mentioning

confidence: 99%

Recent Records on Bacterial Opportunistic Infections via the Dietary Route

Rossi,

Santonicola,

Amadoro

et al. 2023

Microorganisms

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This narrative review was aimed at identifying the opportunistic bacterial pathogens that can be transmitted by contaminated food and represent a current threat for patients particularly susceptible to infections because of underlying conditions or predisposing factors. The analysis was focused on recent case or outbreak reports and systematic reviews published in the years 2019 to 2023 and resulted in sorting 24 bacterial groups comprising the genera or species able to cause a variety of systemic or invasive infections if ingested with food or drinking water. These included both bacteria known to cause mild infections in immunocompetent persons and bacteria considered to be innocuous, which are used in food fermentation or as probiotics. No recent cases of infections transmitted through dietary routes were reported for the critical nosocomial pathogens widely found in food products, primarily Acinetobacter baumannii and Klebsiella pneumoniae. However, the very first sources of their introduction into the clinical environment still need to be established. In many instances, risky dietary habits, such as eating raw fish, seafood, raw meat, unpasteurized milk, and their derived products or the lack of control in fermentation processes, has led to the reported illnesses, pointing out the necessity to improve the hygiene of production and consumer awareness of the risks.

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Time to positivity of blood cultures in bloodstream infections with Streptococcus dysgalactiae and association with outcome

Cited by 6 publications

References 19 publications

Performance of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis in Relation to the Modified Duke Criteria and to Clinical Management—Reanalysis of Retrospective Bacteremia Cohorts

Performance of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis in Relation to the Modified Duke Criteria and to Clinical Management—Reanalysis of Retrospective Bacteremia Cohorts

Predictors of Mortality of Streptococcal Bacteremia and the Role of Infectious Diseases Consultation: A Retrospective Cohort Study

Recent Records on Bacterial Opportunistic Infections via the Dietary Route

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