Time to positivity of neonatal blood cultures: fast and furious?

Guerti, Khadija; Devos, Helena; Ieven, Margareta; Mahieu, Ludo

doi:10.1099/jmm.0.020651-0

Cited by 71 publications

(49 citation statements)

References 24 publications

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“…The amount of time for the results to become available is variable (typically 24-72 h), depending on several factors, including the type of microorganism, and early-versus late-onset sepsis. [15]. Additionally, pathogen identification from positive BC may require additional testing, adding further time and expense [16].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Evaluation of Blood Culture Patterns among Neonates Receiving Vancomycin

et al. 2014

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The objective of this study was to assess the frequency of blood culture (BC) collection among neonates who received vancomycin. Demographic, clinical, microbiologic, and pharmacy data were collected for 1275 neonates (postnatal age 0-27 days) who received vancomycin at an Intermountain Healthcare facility between 1/2006 and 9/2011. Neonates treated with vancomycin had a BC collected 94 % (n = 1198) of the time, of which 37 % (n = 448) grew one or more bacterial organisms (BC positive). Of these, 1 % (n = 5) grew methicillin-resistant Staphylococcus aureus (MRSA), 71 % (n = 320) grew coagulase-negative Staphylococci (CoNS), 9 % (n = 40) grew methicillin-sensitive Staphylococcus aureus (MSSA), and 22 % (n = 97) grew other bacterial species (total exceeds 100 % due to co-detection). In patients with negative BC or no BC, vancomycin therapy was extended beyond 72 h 52 % of the time. The median duration of vancomycin therapy for patients with a negative BC was 4 (IQR: 2-10) days. BCs were frequently obtained among neonates who received vancomycin. Vancomycin therapy beyond the conventional 'empiric' treatment window of 48-72 h was common without isolation of resistant grampositive bacteria.

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Section: Introductionmentioning

confidence: 99%

Epidemiological Evaluation of Blood Culture Patterns among Neonates Receiving Vancomycin

et al. 2014

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“…This means that most of the antibiotics given to babies on the neonatal unit are given to babies without infection. Inappropriate use of antibiotics has been implicated in the development of multiresistant bacteria in hospitals, Recently published studies suggest that antibiotic courses may be safely reduced to 24-36 hours in asymptomatic term babies (Kumar et al, 2001;Khadija et al, 2011).…”

Section: Issn: 2319-7706 Volume 6 Number 4 (2017) Pp 1940-1946mentioning

confidence: 99%

“…Early clinical signs are mostly non-specific and in conclusive (Khadija et al, 2011). Current study was undertaken to find out the common bacterial pathogens and their susceptibility pattern in neonates with sepsis in a tertiary care hospital providing neonatal intensive care services.…”

Section: Issn: 2319-7706 Volume 6 Number 4 (2017) Pp 1940-1946mentioning

confidence: 99%

Blood Culture of Neonates in Paediatric Department and their Antimicrobial Susceptibility Pattern in and around Nims University, Jaipur, India

Chakraborty¹,

Rishi²,

Goyal³

2017

Int.J.Curr.Microbiol.App.Sci

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“…9 Reports of time to positivity of blood and cerebrospinal fl uid (CSF) cultures in neonates suggest that a 48-hour period is necessary to capture an acceptable percentage (generally 95%-99%) of cases, 10,11 and at least 1 investigation has recommended as long as 72 hours. 12 However, these studies included infants in ICUs, increasing estimates of time to positivity due to inclusion of organisms such as coagulase-negative staphylococci and yeasts as pathogens often drawn from central lines. A recent survey of pediatric hospitalists showed that 84% favored a period of hospitalization >36 hours for infants aged <30 days.…”

Section: Ruling Out Bacteremia and Bacterial Meningitis In Infants Lementioning

confidence: 99%

Ruling Out Bacteremia and Bacterial Meningitis in Infants Less Than One Month of Age: Is 48 Hours of Hospitalization Necessary?

Fielding‐Singh

Hong

Harris

et al. 2013

Hospital Pediatrics

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Objective: The appropriate duration of hospitalization for infants ≤ 30 days admitted for fever or other concerns for a serious bacterial infection is an understudied area. We sought to determine the risk of a positive, pathogenic bacterial culture of blood or cerebrospinal fluid (CSF) in this population beyond 24 hours after collection. Methods: This study was a retrospective review of 1145 infants aged ≤30 days who had a blood or CSF culture from 1999 to 2010 at Santa Clara Valley Medical Center, a county health system in San Jose, California. Time to notification and the probability of a positive culture result after 24 hours were calculated. Infants were considered high risk if they had either a white blood cell count <5000 or >15 000 per µL, a band count >1500 per µL, or an abnormal urinalysis. Results: We identified 1876 cultures (1244 blood, 632 CSF) in 1145 infants aged ≤30 days; 901 (79%) of 1145 were hospitalized and 408 (45%) of 901 hospitalizations were for fever without source (FWS). Thirty-one (2.7%) of the 1145 infants had pathogenic cultures; 6 of 1145 infants (0.5% [95% confidence interval: 0.2–1.1]) had a time to notification >24 hours. All 6 patients had FWS (1.5% of hospitalized FWS sample) and met high-risk criteria on presentation. No low-risk patients had a time to notification >24 hours. Low-risk characteristics were found in 57% (232 of 408) of the entire hospitalized FWS population. Conclusions: Low-risk infants hospitalized for FWS or other concerns for serious bacterial infection may not need hospitalization for a full 48 hours simply to rule out bacteremia and bacterial meningitis.

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Time to positivity of neonatal blood cultures: fast and furious?

Cited by 71 publications

References 24 publications

Epidemiological Evaluation of Blood Culture Patterns among Neonates Receiving Vancomycin

Epidemiological Evaluation of Blood Culture Patterns among Neonates Receiving Vancomycin

Blood Culture of Neonates in Paediatric Department and their Antimicrobial Susceptibility Pattern in and around Nims University, Jaipur, India

Ruling Out Bacteremia and Bacterial Meningitis in Infants Less Than One Month of Age: Is 48 Hours of Hospitalization Necessary?

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