Time to pregnancy in women with previous ectopic pregnancy undergoing in vitro fertilization treatment: a retrospective cohort study

Xue, Yamei; Zhang, Fuxing; Zhang, Haocheng

doi:10.1038/s41598-022-13027-1

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…(Weström et al, 1981) A pregnancy is considered ectopic when embryo implants in the fallopian tube or outside the uterine cavity. (Xue et al, 2022) Ectopic pregnancy can result in infertility and about 35% women with this condition have difficulty getting pregnant. (Ectopic Pregnancy, n.d.)…”

Section: Tubal Infertilitymentioning

confidence: 99%

Predictors of fertility quality of life in infertile patients visiting infertility center in Kathmandu, Nepal : a cross-sectional study.

Shakya

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In Nepal, infertility is a rising reproductive health issue with an estimated prevalence of 15%. There are few studies on quality of life in infertile women, but none on quality of life in infertile men and women although infertility is a shared condition and has effects on couples. The study objective is to describe the various predictors of infertile patients seeking infertility treatment and find association between these predictors and the quality of life. A cross-sectional study using a self-administered disease specific FertiQoL questionnaire was conducted among 409 infertile men and women seeking infertility treatment in an infertility center in Kathmandu district. Multistage, purposive, convenience sampling technique was used. Frequency and percentages were used to describe the predictor variables socio-demographic, socio-economic, couple-related, fertility related characteristics and medical history. Almost all the respondents felt that having a child was very important to them and their partners were supportive throughout the infertility treatment. Almost 60% of respondents were experiencing primary infertility and 53% had a history of assisted reproductive technologies (ART) failure. Forty seven percent and 19% respondents were undergoing ART using self-gametes and donor respectively. Eighty percent of respondents desired professional psychological support following ART treatment. Forty eight percent of respondents had poor QoL. Their associations with the outcome variable poor Fertility Quality of Life were tested for significance by bivariate and multivariate analysis. The bivariate association between the predictor and outcome variables were analyzed by using a chi-square test. The results show highly significant statistical association at p-value 0.001 for independent variables; travel long distance for service, desire for professional psychological support, duration of infertility, history of ART treatment and current infertility treatment. Similarly, a statistically significant association at p-value 0.05 was found for the following variables: sex, work hours, access to day-off from work, cognition for need of children, duration of infertility and history of reproductive tract surgery. All other variables were not significant. The multivariate logistic regression model entered all the following variables from bivariate analysis; all those given above with significance p-value 0.05, those with p-value 0.2; age, ethnicity, family type, income level, partner's supportiveness, approach to fertility center, cause of infertility, presence for chronic illness, intake of medications and finally the variables education and type of infertility which were significant in the literature. The multivariate analysis results by multiple logistic regression have shown statistically significant association for the following variables; female gender (AOR=1.81, 95% CI=0.32-0.80, p-value 0.004), difficult access to get time off from work (AOR=1.96, 95% CI=1.24-3.09, p-value 0.004), long travel distance for fertility treatment (AOR=0.50, 95% CI=1.15-2.86, p-value 0.011), more than 10 years of marital duration (AOR= 1.68, 95% CI = 1.04-2.71, p-value 0.032), undergoing ART using self-gametes (AOR=1.71, 95% CI=1.05-2.8, p-value 0.030), undergoing donor ART cycles (AOR=1.99, 95% CI=1.07-3.71, p-value 0.030), and desire for professional psychological support (AOR=2.21, 95% CI=1.26-3.89, p-value 0.006). To further enhance the quality of life among infertile patients, it is recommended to provide psychological and emotional support to the patients undergoing infertility treatment. Qualitative studies are also recommended to understand how the quality of life is influenced by the coping capability and behavior of the partner.

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Section: Tubal Infertilitymentioning

confidence: 99%

Predictors of fertility quality of life in infertile patients visiting infertility center in Kathmandu, Nepal : a cross-sectional study.

Shakya

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Is it necessary to perform a routine hysteroscopy before first embryo transfer in patients with previous ectopic pregnancy history: A propensity score matching analysis?

Xiao,

Liao,

Lin

et al. 2024

Preprint

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Purpose To determine whether an office hysteroscopy is required before the first embryo transfer in infertile women with previous ectopic pregnancy history. Methods Consecutive patients with previous ectopic pregnancy history were categorized into two groups based on the performance of hysteroscopy. Subgroup 1 consisted of patients whose endometrial pathology was normal, subgroup 2 who were diagnosed with endometrial polyps (EP), and subgroup 3 diagnosed with chronic endometritis (CE). Demographics, baselines of characteristics, and pregnancy outcomes after embryo transfer were compared among these groups. Results A total of 614 patients were enrolled. No differences were observed in the baseline characteristics of these groups. The clinical pregnancy rates were comparable between hysteroscopy group and non-hysteroscopy group. The spontaneous miscarriage rate was greater in the cured CE subgroup compared to the normal and EP subgroups. Consequently, the live birth rate was comparatively lower in the cured CE group than in both the control group and the EP group. Conclusions We found a high pregnancy loss rate in women with CE-confirmed immunohistochemically. While office hysteroscopy serves as a valuable diagnostic instrument, it is imperative that it be supplemented with appropriate and adequate antibiotic therapy. Further investigation is still required before it can be considered a standard infertile workup before the first embryo transfer in patients with previous ectopic pregnancy history. Trial registration N/A.

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Time to pregnancy in women with previous ectopic pregnancy undergoing in vitro fertilization treatment: a retrospective cohort study

Cited by 2 publications

References 28 publications

Predictors of fertility quality of life in infertile patients visiting infertility center in Kathmandu, Nepal : a cross-sectional study.

Predictors of fertility quality of life in infertile patients visiting infertility center in Kathmandu, Nepal : a cross-sectional study.

Is it necessary to perform a routine hysteroscopy before first embryo transfer in patients with previous ectopic pregnancy history: A propensity score matching analysis?

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