2010
DOI: 10.1097/hjh.0b013e32833b912c
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Time to re-appraise the role of alpha-1 adrenoceptor antagonists in the management of hypertension?

Abstract: The role of alpha-1 adrenoceptor antagonists (alpha-blockers) in the management of hypertension continues to evolve. Recent data support their use as add-on therapy in uncontrolled hypertension when used in combination with all other major classes of antihypertensive drug and there is increasing evidence suggesting that they have modest but significant beneficial effects on lipid and glucose metabolism. The availability of extended-release formulations has contributed to an excellent tolerability profile. New … Show more

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Cited by 44 publications
(29 citation statements)
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References 44 publications
(81 reference statements)
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“…To sum up, antagonists of a 1 -AR are still successfully used as antihypertensive drugs in patients with hypertension coexisting with impaired lipid profile and carbohydrate metabolism 27,28 and for concomitant hypertension with benign prostatic hyperplasia. 29 The a 1 -adrenoceptor remains a good target in the search for safer and more effective drugs.…”
Section: Resultsmentioning
confidence: 99%
“…To sum up, antagonists of a 1 -AR are still successfully used as antihypertensive drugs in patients with hypertension coexisting with impaired lipid profile and carbohydrate metabolism 27,28 and for concomitant hypertension with benign prostatic hyperplasia. 29 The a 1 -adrenoceptor remains a good target in the search for safer and more effective drugs.…”
Section: Resultsmentioning
confidence: 99%
“…The possible explanation in our clinical research is the timing of doses without achieving the titration of maximum dose/clinical response time. The effect of time on the efficacy of α-blockers is discussed by Chapman et al, who showed that the timing of doses of α-adrenergic blocking agents may affect their efficacy [23].…”
Section: Discussionmentioning
confidence: 99%
“…Doxazosin wird am häufigsten eingesetzt. Aufgrund der selektiven α-1-Blockade kommt es nicht zu Reflextachykardien, die BlutHirn-Schranke wird in deutlich geringerem Ausmaß passiert, wodurch zentrale Nebenwirkungen gering ausfallen [8]. Postoperative Hypotensionen werden nur sehr selten beobachtet [5,23].…”
Section: Alternative Therapieformenunclassified
“…Ein weiterer Vorteil ist die gute Verträglichkeit des Medikaments. So konnte gezeigt werden, dass sich der Blutdruck bei hypertensiven Patienten durch die Gabe von Doxazosin GITS effektiv senken ließ, bei normotensiven Patienten allerdings kam es nicht zu signifikanten Blutdruckabfällen [8,19].…”
Section: Alternative Therapieformenunclassified