Time Trend of Outcomes for Severe Acute Pancreatitis After Publication of Japanese Guidelines Based on a National Administrative Database

Murata, Atsuhiko; Mayumi, Toshihiko; Okamoto, Kohji; Ohtani, Makoto; Matsuda, Shinya

doi:10.1097/mpa.0000000000000490

Cited by 3 publications

(3 citation statements)

References 41 publications

(113 reference statements)

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“…However, about 20% of cases are clinically severe [2]. Globally, in-hospital mortality rate of patients with severe acute pancreatitis (SAP) are estimated to be 5%-42% [3][4][5][6]. Patients with SAP usually present with fever, abdominal pain, subcutaneous bleeding, sepsis, and sometimes systematic inflammatory response syndrome and multiple organ dysfunction syndrome.…”

Section: Introductionmentioning

confidence: 99%

Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double‐Blinded, Placebo‐Controlled, Randomized Clinical Trial

Yang

Qi²,

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The red peony root derived from Paeonia lactiflora has been applied to treat human inflammatory diseases. To investigate its therapeutic potential in treating moderately severe acute pancreatitis (MSAP), which has been rarely studied, this study was designed as a double-blinded, placebo-controlled, randomized clinical trial. A total of 60 MSAP patients were enrolled and randomly divided into an experimental (n = 30) group and a control group (n = 30), who received a coloclyster of 15 g of red peony root or placebo granules dissolved in 150 mL of water, respectively. The patients’ demographic and clinical characteristics were recorded. The results showed that the experimental group had a shorter remission time of fever (p<0.05) and abdominal pain (p<0.01) and faster resumption of self-defecation (p<0.01) than did the control group. In addition, the coloclyster of red peony root decreased the modified Balthazar CT score as well as the serum interleukin-6 and tumor necrosis factor-alpha levels to a greater extent than did the placebo coloclyster (p<0.05). The remission times for the normalization of white blood cells and percentage of neutrophils and lymphocytes in the experimental group were also significantly shorter than those in the control group (p<0.05). In conclusion, a coloclyster of red peony root could help alleviate the clinical symptoms and shorten the course of MSAP by possibly attenuating systematic inflammation. This trial is registered with 14004664.

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Section: Introductionmentioning

confidence: 99%

Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double‐Blinded, Placebo‐Controlled, Randomized Clinical Trial

Yang

Qi²,

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Using the DPC database, previous studies have revealed the clinical practice of AP in Japan. [12][13][14] This study aimed to clarify the updated clinical practice of AP in Japan as well as its trend before and after the revision of the Japanese guidelines using the DPC database.…”

mentioning

confidence: 99%

“…The database includes basic hospitalization information such as age, sex, comorbidities at admission, dates of admission and discharge, history of admission to the intensive care unit (ICU), medications and interventional procedures, and outcomes at discharge. Using the DPC database, previous studies have revealed the clinical practice of AP in Japan 12–14 . This study aimed to clarify the updated clinical practice of AP in Japan as well as its trend before and after the revision of the Japanese guidelines using the DPC database.…”

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confidence: 99%

Acute Pancreatitis in Japan

Ikeda¹,

Hamada²,

Kikuta³

et al. 2022

Pancreas

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ObjectivesCases of acute pancreatitis (AP) are increasing worldwide, and mortality remains high in severe cases. In 2015, the Japanese guidelines for the management of AP were revised. We aimed to clarify the clinical practice of AP in Japan and its trend during the revision of the guidelines using a Japanese nationwide administrative database.MethodsWe retrospectively analyzed 102,119 patients with AP who were hospitalized between April 2014 and March 2018. The study period was divided into the first period (the time before the revision: fiscal years 2014 and 2015) and second period (after the revision: 2016 and 2017).ResultsSevere cases of AP accounted for 27.7% of total cases. The in-hospital mortality in severe cases was 5.7%. The mortality within 14 days of admission improved from 3.2% in the first period to 2.6% in the second period (P = 0.022). Referred patients had more severe diseases and a higher mortality. The mortality in patients who underwent endoscopic ultrasound-guided fistuloplasty for local complications (11.6%) was lower than that in patients who underwent percutaneous drainage (23.4%) or AP surgery (22.6%) (P < 0.001).ConclusionsWe clarified the clinical practice of AP including the improved mortality after the revision of the guidelines.

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Etiology and mortality in severe acute pancreatitis: A multicenter study in Japan

et al. 2020

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Time Trend of Outcomes for Severe Acute Pancreatitis After Publication of Japanese Guidelines Based on a National Administrative Database

Abstract: This study shows that mortality of severe acute pancreatitis was reduced according to the time course, whereas LOS or medical costs were stable after publication of the Japanese guidelines.

Cited by 3 publications

References 41 publications

Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double‐Blinded, Placebo‐Controlled, Randomized Clinical Trial

Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double‐Blinded, Placebo‐Controlled, Randomized Clinical Trial

Acute Pancreatitis in Japan

Etiology and mortality in severe acute pancreatitis: A multicenter study in Japan

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