Time trends in cancer incidence in Australian people living with HIV between 1982 and 2012

Wong, Ian K. J.; Grulich, Andrew E.; Poynten, I. Mary; Polizzotto, Mark N.; Leeuwen, Marina T. van; Amin, Janaki; McGregor, Skye; Law, Matthew; Templeton, David J; Vajdic, Claire M.; Jin, Fengyi

doi:10.1111/hiv.13179

Cited by 11 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, an analysis of cancers overall in this identical Australian cohort identified substantially higher rates of many cancers, particularly NHL, HL, KS, and anal and liver cancers, compared with those in the general population. 5 In our study, the incidence of SPC overall in PLWHIV did not significantly change between 1982 and 2012. The most common SPCs were non-Hodgkin lymphoma (mostly diffuse large B-cell lymphoma), KS, and anal cancer.…”

Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

“…1 However, the incidence of these and certain other malignancies including lung cancer, cervical cancer, anal cancer, and Hodgkin lymphoma (HL), remains significantly higher in people living with HIV (PLWHIV) compared with that in their HIV-negative peers. [2][3][4][5] With advances in HIV treatment and care, the median age of PLWHIV is increasing, and cancers associated with aging are becoming more prominent. 6,7 Distinct pathophysiological factors contribute to the elevated cancer risk in PLWHIV.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Second Primary Cancers in People With HIV/AIDS: A National Data Linkage Study of Incidence and Risk Factors

Ciaccio

Amin

et al. 2023

JAIDS Journal of Acquired Immune Deficiency Syndromes

Self Cite

View full text Add to dashboard Cite

Background: Evidence regarding the characteristics of second primary cancer (SPC) in people living with HIV (PLWHIV) is limited.Setting: We performed a national population-based data linkage study to determine the incidence and risk factors of SPC in PLWHIV in Australia between 1982 and 2012. Methods:We conducted a probabilistic data linkage study to compare the incidence of SPC over time, defined using HIV treatment eras, for SPCs related to oncogenic viral infection in comparison with non-infection-related SPCs. Risk factors considered included age at diagnosis of cancer, sex, HIV exposure modality, and CD4 + count.Results: Of 29,383 individuals diagnosed with HIV, 3123 individuals who developed a first primary cancer were included in the analysis. Among them, 229 cases of SPC were identified across 27,398 person-years of follow-up. The most common SPCs were non-Hodgkin lymphomas (n = 71, 31%). The incidence of SPC overall did not change over time; however, there was an increase in individuals diagnosed with HIV in later eras (P trend =0.001). The incidence of non-infection-related SPC increased over time and was associated with older age (P trend = 0.005) and the acquisition of HIV in later eras (P trend ,0.001). Conversely, the incidence of infection-related SPC decreased (P trend ,0.001), but this was no longer significant after adjustment for age (P trend = 0.14). Conclusions:The risk of SPC in PLWHIV in Australia remains high, with a temporal increase observed in non-infection-related cancer, likely due to aging of the population. Optimal screening and prevention strategies for SPC in PLWHIV are increasingly important.

show abstract

Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Second Primary Cancers in People With HIV/AIDS: A National Data Linkage Study of Incidence and Risk Factors

Ciaccio

Amin

et al. 2023

JAIDS Journal of Acquired Immune Deficiency Syndromes

Self Cite

View full text Add to dashboard Cite

show abstract

“…Meanwhile, the incidence of non-AIDS-related cancers rise in HIV-infected patients in Western countries [ 24 , 25 ]. More recent data from studies of HIV-infected people in the US, Europe and Australia indicated that non-AIDS-related cancers increased, reflecting increasing rates in the general population [ 26 , 27 ]. In developing countries, including China, there are a large proportion of newly-HIV infected people, AIDS-related cancers are the most common malignances [ 24 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Features, Phenotypic Markers and Outcomes of Diffuse Large B-Cell Lymphoma between HIV-Infected and HIV-Uninfected Chinese Patients

Zhou

Cheng

Zhao

et al. 2022

Cancers

View full text Add to dashboard Cite

Background: The effect of HIV infection on the clinicopathological characteristics of diffuse large B-cell lymphoma (DLBCL) remains debatable. Methods: Fifty-three HIV-infected and ninety-three HIV-uninfected DLBCL patients were enrolled in the retrospective study by propensity score matching for sex, age, body mass index and international prognostic index (IPI) at a ratio of 1:2. The clinicopathological characteristics were compared between the two groups. Results: HIV-infected DLBCL patients had lower white blood cell counts [×109/L; 4.4(3.4–5.6) vs. 6.1(4.2–8.2), p < 0.001], platelet counts ((×109/L; 184.7 ± 89.3 vs. 230.0 ± 113.9, p = 0.014) and serum albumin (g/L; 37.3 ± 6.9 vs. 41.3 ± 6.2, p < 0.001) but higher incidences of central nervous system (CNS) involvement (9.4% vs. 1.1%, p = 0.014), bone marrow involvement (24.5% vs. 11.5%, p = 0.044) and Epstein–Barr viremia (61.1% vs. 26.7%, p = 0.002) than HIV-uninfected patients. In terms of histopathology, HIV-infected patients had higher positivity of Epstein–Barr virus-encoded small RNA (EBER) (41.7% vs. 6.7%, p = 0.002), but lower CD20 (90.2% vs. 98.7%, p= 0.029) and CD79a (23.1% vs. 53.7%, p < 0.001) expression. The overall response rate (ORR) at the end of chemotherapy (70.2% vs. 87.8%, p= 0.012) and 1-year overall survival (OS) (61.7% vs. 84.2%, log-rank p = 0.006) in HIV-infected patients were significantly lower than those in HIV-uninfected patients. Multivariate analysis suggested IPI ≤2.0 [adjusted odds ratio (AOR) (95% confidence interval): 5.0 (1.2–21.2), p = 0.030] was associated with ORR, hypoalbuminemia [AOR: 3.3(1.3–9.1), p = 0.018] and CNS involvement [AOR: 3.3(1.0–10.5), p = 0.044] were associated with reduced 1-year OS in HIV-infected patients. Conclusions: HIV-infected DLBCL patients have unique blood profiles and phenotypic markers. Low ORR and 1-year OS were observed in HIV-infected DLBCL patients in our study, even in the HAART era.

show abstract

“…Cancer incidence and burden (ie, the number of new cases) among PLWH is strongly influenced by the characteristics of the population living with HIV (eg, demographics, co‐infections, co‐morbidities), availability of timely ART and access to health care—all factors that differ across countries and regions of the world, and over time. The types of cancer that occur at higher rates among PLWH are largely consistent across countries and are typically caused by oncogenic viruses 4‐8 . However, rates of KS, cervical and conjunctival cancer remain much higher in sub‐Saharan Africa (SSA) than in Europe, Latin America and North America (Figure 1).…”

Section: International Patterns In Cancer Incidencementioning

confidence: 99%

State of the science and future directions for research on HIV and cancer: Summary of a joint workshop sponsored by IARC and NCI

Engels,

Shiels,

Barnabas

et al. 2023

Intl Journal of Cancer

View full text Add to dashboard Cite

An estimated 38 million people live with human immunodeficiency virus (HIV) worldwide and are at excess risk for multiple cancer types. Elevated cancer risks in people living with HIV (PLWH) are driven primarily by increased exposure to carcinogens, most notably oncogenic viruses acquired through shared transmission routes, plus acceleration of viral carcinogenesis by HIV‐related immunosuppression. In the era of widespread antiretroviral therapy (ART), life expectancy of PLWH has increased, with cancer now a leading cause of co‐morbidity and death. Furthermore, the types of cancers occurring among PLWH are shifting over time and vary in their relative burden in different parts of the world. In this context, the International Agency for Research on Cancer (IARC) and the US National Cancer Institute (NCI) convened a meeting in September 2022 of multinational and multidisciplinary experts to focus on cancer in PLWH. This report summarizes the proceedings, including a review of the state of the science of cancer descriptive epidemiology, etiology, molecular tumor characterization, primary and secondary prevention, treatment disparities and survival in PLWH around the world. A consensus of key research priorities and recommendations in these domains is also presented.

show abstract

Time trends in cancer incidence in Australian people living with HIV between 1982 and 2012

Cited by 11 publications

References 41 publications

Second Primary Cancers in People With HIV/AIDS: A National Data Linkage Study of Incidence and Risk Factors

Second Primary Cancers in People With HIV/AIDS: A National Data Linkage Study of Incidence and Risk Factors

Clinical Features, Phenotypic Markers and Outcomes of Diffuse Large B-Cell Lymphoma between HIV-Infected and HIV-Uninfected Chinese Patients

State of the science and future directions for research on HIV and cancer: Summary of a joint workshop sponsored by IARC and NCI

Contact Info

Product

Resources

About