2015
DOI: 10.1002/acr.22512
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Time Trends in Incidence, Clinical Features, and Cardiovascular Disease in Ankylosing Spondylitis Over Three Decades: A Population‐Based Study

Abstract: Objective To determine trends in the incidence and clinical presentation of ankylosing spondylitis (AS), the incidence of cardiovascular disease (CVD) and cardiovascular (CV) risk factors among patients with AS and compare the observed incidence of CVD with that predicted by the Framingham risk score (FRS). Method A population-based inception cohort of residents of Olmsted County, Minnesota ≥18 years who fulfilled modified New York criteria for AS in 1980-2009 was assembled. Clinical features at presentation… Show more

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Cited by 52 publications
(43 citation statements)
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“…The incidence of AS remained stable from 1980 to 2009 at 3.1 per 100,000 persons, with a male to female ratio of 3.8:1. 10 Notably, findings from this study suggest that long-standing observations of sex-based differences in AS prevalence seem to be declining, as previous publications reported male to female ratios of up to 9:1. 10 Clinical features at presentation and time to diagnosis are generally similar between men and women (time from symptom onset to diagnosis of w6 years), but uveitis occurs more commonly in women.…”
Section: Epidemiology Of Axspasupporting
confidence: 48%
See 1 more Smart Citation
“…The incidence of AS remained stable from 1980 to 2009 at 3.1 per 100,000 persons, with a male to female ratio of 3.8:1. 10 Notably, findings from this study suggest that long-standing observations of sex-based differences in AS prevalence seem to be declining, as previous publications reported male to female ratios of up to 9:1. 10 Clinical features at presentation and time to diagnosis are generally similar between men and women (time from symptom onset to diagnosis of w6 years), but uveitis occurs more commonly in women.…”
Section: Epidemiology Of Axspasupporting
confidence: 48%
“…7 Extra-articular manifestations, including inflammatory bowel disease (IBD), acute anterior uveitis/iritis, aortic insufficiency, and enthesitis, are observed and can substantially affect the prognosis. 9,10 Patients with AxSpA are also at increased risk for cardiovascular and other comorbidities, including ischemic heart disease, hypertension, diabetes mellitus, osteoporosis, and atrioventricular block. 9,11 Note that the hallmark of AS is radiographic detection of sacroiliitis or syndesmophytes on lumbosacral spine radiographs, but MRI detection of sacroiliitis may also aid in establishing an accurate diagnosis in patients with AxSpA.…”
mentioning
confidence: 99%
“…Cardiac involvement in AS has been known for a long time, in particular alterations of the aortic root geometry and aortic valve dysfunction . As in other inflammatory joint diseases, there is an increased risk of premature atherosclerosis in AS . However, the risk of myocardial infarction has been shown to be only one‐half as high in AS patients compared to that observed in patients with rheumatoid arthritis (RA) .…”
Section: Introductionmentioning
confidence: 99%
“…Extra-articular manifestations, such as uveitis, could be seen in about one-fourth of patients with AS. [17]…”
Section: Introductionmentioning
confidence: 99%