Time Trends in the Incidence of Testicular Cancer in Childhood and Young Adulthood

Lacerda, Hadriano M.; Akre, Olof; Merletti, Franco; Richiardi, Lorenzo

doi:10.1158/1055-9965.epi-08-1140

Cited by 19 publications

(17 citation statements)

References 13 publications

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“…Increasing incidence of specific cancers such as thyroid [33-35], testicular [36,37] observed in this study population appears to be consistent with results from other AYA populations. The emerging lung cancer epidemic observed among females in our study is also consistent with other studies from several developed countries [38-41].…”

Section: Discussionsupporting

confidence: 90%

Cancer incidence and mortality trends in Australian adolescents and young adults, 1982–2007

et al. 2012

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BackgroundIncreasing incidence and lack of survival improvement in adolescents and young adults (AYAs) with cancer have led to increased awareness of the cancer burden in this population. The objective of this study was to describe overall and type-specific cancer incidence and mortality trends among AYAs in Western Australia from 1982–2007.MethodsAge–adjusted incidence and mortality rates were calculated for all malignancies combined and for each of the most common diagnostic groups, using five-year age–specific rates. Joinpoint regression analysis was used to derive annual percentage changes (APC) for incidence and mortality rates.ResultsThe annual incidence rate for all cancers combined increased in males from 1982 until 2000 (APC = 1.5%, 95%CI: 0.9%; 2.1%) and then plateaued, whilst rates for females remained stable across the study period (APC = −0.1%; 95%CI: −0.2%; 0.4%) across the study period. For males, significant incidence rate increases were observed for germ cell tumors, lymphoblastic leukemia and thyroid cancer. In females, the incidence of Hodgkin’s lymphoma, colorectal and breast cancers increased. Significant incidence rate reductions were noted for cervical, central nervous system and lung cancers. Mortality rates for all cancers combined decreased from 1982 to 2005 for both males (APC = −2.6%, 95%CI:−3.3%;−2.0%) and females (APC = −4.6%, 95%CI:−5.1%;−4.1%). With the exception of bone sarcoma and lung cancer in females, mortality rates for specific cancer types decreased significantly for both sexes during the study period.ConclusionsIncidence of certain AYA cancers increased, whilst it decreased for others. Mortality rates decreased for most cancers, with the largest improvement observed for breast carcinomas. Further research is needed to identify the reasons for the increasing incidence of certain cancers.

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Section: Discussionsupporting

confidence: 90%

Cancer incidence and mortality trends in Australian adolescents and young adults, 1982–2007

et al. 2012

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“…32 Age-period-cohort models of TGCT incidence demonstrate robust calendar period deviation, adding additional support for the role of postnatal exposures in the etiology of these tumors. 32 …”

Section: Discussionmentioning

confidence: 86%

Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor

Biggs

Doody

Trabert

et al. 2016

Intl Journal of Cancer

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The etiology of testicular germ cell tumor (TGCT) remains obscure, and accumulating evidence suggests that postnatal environmental or lifestyle factors may play a role. To investigate whether consumption of alcoholic beverages during adolescence or adulthood is associated with TGCT risk, we analyzed data from a USA population-based case-control study of 540 18–44 year-old TGCT cases, and 1,280 age-matched controls. Participants were queried separately about consumption of beer, wine and liquor during grades 7–8, grades 9–12 and the 5 years before reference date (date of diagnosis for cases and corresponding date for controls). We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association of TGCT risk with alcoholic beverage consumption during the different periods, both total and by specific beverage types, and separately for seminomas and nonseminomas. Compared with non-drinkers in the 5 years before reference date, the OR (95% CI) for 1–6, 7–13, and ≥14 drinks per week were 1.20 (0.85, 1.69), 1.23 (0.81, 1.85), and 1.56 (1.03, 2.37), respectively (p-trend=0.04). The corresponding results for alcohol consumption in grades 9–12 were 1.39 (1.06, 1.82), 1.07 (0.72, 1.60), 1.53 (1.01, 2.31) (p-trend=0.05). Alcohol consumption in grades 7–8 was uncommon and no statistically significant associations with TGCT were observed. Associations with alcohol consumption in the 5 years before reference date appeared stronger for nonseminomas than for seminomas, but the differences were not statistically significant (p>0.05). Associations were similar across different alcoholic beverage types. Consumption of alcoholic beverages may be associated with an increased TGCT risk.

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“…Such a trend is consistent with the growing tendency reported in the majority of industrialized countries in North America, Europe and Oceania. 28 Although the causes of the increase remain unexplained, it seems that different factors act in adulthood and childhood, 29 with the most relevant considered to be prenatal risks (e.g. intrauterine growth retardation, cryptorchidism, etc.)…”

Section: Discussionmentioning

confidence: 99%

Ageing and other factors behind recent cancer incidence and mortality trends in Italy

Crocetti¹,

Buzzoni²,

Quaglia

et al. 2012

Journal of Geriatric Oncology

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Time Trends in the Incidence of Testicular Cancer in Childhood and Young Adulthood

Cited by 19 publications

References 13 publications

Cancer incidence and mortality trends in Australian adolescents and young adults, 1982–2007

Cancer incidence and mortality trends in Australian adolescents and young adults, 1982–2007

Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor

Ageing and other factors behind recent cancer incidence and mortality trends in Italy

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