Time Trends in the Incidence and Mortality of Ovarian Cancer in Ireland, Northern Ireland, and Israel, 1994–2013

Keinan‐Boker, Lital; Silverman, Barbara; Walsh, Paul; Gavin, Anna; Hayes, Christine

doi:10.1097/igc.0000000000001079

Cited by 6 publications

(7 citation statements)

References 36 publications

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“…We observed modest decrease in ovarian cancer mortality rates in Lithuania. Results are in line with those reported in previous studies, where decreasing rates were observed [ 2 , 11 , 20 , 21 ]. Significant period effect, detected in our study, indicates improvements in diagnosis or treatment of ovarian cancer.…”

Section: Discussionsupporting

confidence: 93%

Trends in Mortality Rates of Corpus Uteri and Ovarian Cancer in Lithuania, 1987–2016

Everatt

Intaitė

2020

Medicina

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Background: The corpus uteri and ovarian cancers burden in Lithuania has remained high. The aim of this study was to investigate time trends in mortality rates of corpus uteri and ovarian cancer in Lithuania across age groups and time periods over a 30-year time span. Materials and Methods: Data on numbers of deaths from corpus uteri cancer during the period 1987–2016 and ovarian cancer during the period 1993–2016 were obtained from the WHO mortality database. Trends in age-standardized mortality rates (ASR, world standard), and age-specific rates were analyzed by calculating annual percentage change using Joinpoint regression. In addition, age–period–cohort analysis was performed for each cancer type. Results: Mortality from corpus uteri cancer decreased by −1.2% (95% CI: −1.8; −0.7) annually from 1987 to 2016. Decrease was most pronounced in youngest age group of 40–49 years; annual percentage change was −2.4 (95% CI: −4.0; −0.9). Mortality rates for ovarian cancers decreased by −1.2% (95% CI: −1.6; −0.8) annually from 1993 to 2016. Corpus uteri and ovarian cancer ASRs in 2016 were 3.5/100,000 and 7.4/100,000, respectively. The age–period–cohort analysis suggests that temporal trends in corpus uteri cancer mortality rates could be attributed to period and cohort effects. Conclusion: A reduction in mortality rate was observed for corpus uteri and ovarian cancer over the entire study period. Similar decreasing pattern for corpus uteri and ovarian cancer mortality indicate effect of shared factors.

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Section: Discussionsupporting

confidence: 93%

Trends in Mortality Rates of Corpus Uteri and Ovarian Cancer in Lithuania, 1987–2016

Everatt

Intaitė

2020

Medicina

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“… 24 However, there was a reduction in cancer incidence in Israeli Jews and the Philippines. 25 , 26 There were several reasons for explaining the increasing incidence trends in Korea and Japan. Over diagnosis of some cancers (like thyroid cancer) could one reason for the increasing trend of cancer incidence, especially in Korea.…”

Section: Discussionmentioning

confidence: 99%

Cancer Incidence and Mortality in Asian Countries: A Trend Analysis

et al. 2022

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Background This study aimed to evaluate the updated burden and temporal trends of cancer incidence and mortality in Asian countries. Methodology The data used in this study were retrieved from the Global Cancer Observatory, Cancer Incidence in Five Continents volumes I-XI, and the World Health Organization mortality database. These data were used to calculate the Average Annual Percentage Change (AAPC), with a 95% confidence interval (CI) by joinpoint regression analysis to determine the epidemiological trend in the past decade. Results In 2020, the cancer incidence in Asia was 169.1 per 1 00 000, accounting for 49.3% of the global cancer incidence. The most common cancers included lung (13.8%), breast (10.8%) and colorectal (10.6%) cancers. Its mortality was 101.6 per 1 00 000 (58.3% of the global cancer death) with lung (19.2%), liver (10.5%) and stomach (9.9%) cancers being the most common causes of cancer death. The cancer incidence had been increasing in female population, with Korea (AAPC = 5.73, 95% CI [5.30, 6.17], P < .001), Japan (AAPC = 2.67, 95% CI [2.12, 3.23], P < .001) and Kuwait (AAPC = 2.08, 95% CI [.49, 3.69], P = .016) showing the most significant increases in the past decade. The incidence increase was also observed among population aged <40 years old, with Korea (female AAPC = 8.42, 95% CI [7.40, 9.45], P < .001; male AAPC = 5.28, 95% CI [4.23, 6.33], P <.001), China (female AAPC = 2.94, 95% CI [2.07, 3.81], P < .001; male AAPC = 1.37, 95% CI [.57, 2.18], P = .004) and Japan (female AAPC = 2.88, 95% CI [1.88, 3.88], P = .016; male AAPC = 1.59, 95% CI [.40, 2.78], P = .015) showing the most significant increases. However, there was an overall decreasing trend of cancer mortality. Conclusions There was a substantial burden of cancer incidence and mortality in Asia. Although there was a decreasing trend in cancer mortality, its incidence had been increasing especially among female and younger populations. Future studies could be done to further investigate the potential reasons for these epidemiologic trends.

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“…Ovarian cancer is a cosmopolitan disease as it occurs in every geographical location and in every race [1,30]. Epithelial ovarian cancer is the commonest subtype all around the world with high-grade serous accounting for 60-85% of cases [22,[35][36][37][38].…”

Section: Racial and Geographical Riskmentioning

confidence: 99%

“…Recent statistics from the US show a decline in incidence from 16.6/100,000 in 1985 to 11.8/100,000 in 2018 [39]. Incidence is also high in New Zealand and among Jewish women in Israel but low in Africa and Asia with estimated rates of <3/100,000 [37]. Japan, though reported to have low incidence is experiencing a rising trend in the disease of recent [40].…”

Section: Racial and Geographical Riskmentioning

confidence: 99%

Risk Factors for Ovarian Cancer

Zayyan¹

2020

Tumor Progression and Metastasis

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Ovarian cancers remain a perplexing group of diseases that continue to raise questions over their etiology and clinical behavior. They are the most fatal of gynecological cancers. Despite a global lifetime risk of only 1-2%, they contribute the highest mortality and the lowest 5-year (overall) survival rate of just 35%. The three broad histological groups: epithelial, sex cord-stromal and germ cell cancers have different biologic behavior and may constitute different clinical disease entities. Of the eight subtypes in the epithelial group, high-grade serous are universally the most common and have the worst prognosis. Globally making 65-85% of all ovarian cancers, most of the focus on risk factors has been directed on the epithelial group but the importance of other primary malignancies cannot be overemphasized as a step towards understanding their etiology and clinical behavior. The normal ovary has none of the epithelia that produce the range of epithelial ovarian cancers or there is an obvious premalignant stage, symptoms are very vague, screening and early diagnosis are difficult and indeed unrewarding. No specific etiology is known for any of the histologic groups. However, commonly mentioned risk factors like increasing age, genetics, nulliparity, prolonged infertility, use of fertility drugs, high animal fat, obesity, endometriosis, polycystic ovary syndrome, previous history of cancer, use of hormone replacement therapy, pelvic inflammatory disease and smoking may not apply to all the subtypes, while factors like increasing parity, breast feeding, use of oral contraceptive pills, hysterectomy, tubal ligation and use of antioxidants may differ in the degree of protection they provide. There may also be geographical and probably racial variations in the relevance of some of the risk factors. Thorough understanding of the predisposing and protective factors of the various histologic subtypes is an important step understanding the disease and therefore improving treatment outcome or providing effective prevention.

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Time Trends in the Incidence and Mortality of Ovarian Cancer in Ireland, Northern Ireland, and Israel, 1994–2013

Cited by 6 publications

References 36 publications

Trends in Mortality Rates of Corpus Uteri and Ovarian Cancer in Lithuania, 1987–2016

Trends in Mortality Rates of Corpus Uteri and Ovarian Cancer in Lithuania, 1987–2016

Cancer Incidence and Mortality in Asian Countries: A Trend Analysis

Risk Factors for Ovarian Cancer

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