Time Trends of Aspirin and Warfarin Use on Stroke and Bleeding Events in Chinese Patients With New-Onset Atrial Fibrillation

Guo, Yutao; Wang, Hao; Yingchun, Tian; Wang, Yutang; Lip, Gregory Y.H.

doi:10.1378/chest.14-2018

Cited by 44 publications

(44 citation statements)

References 36 publications

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“…The results of current study show that the OAC treatment in patients with AF may be improving in China, consistent with previous studies. 21 In the quality evaluation of stroke care and treatment (ChinaQUEST) study, 22 which registered patients with recent stroke in 2006, in-hospital OAC use was 11% among patients with nonvalvular AF. In the China National Stroke Registry II conducted from 2012 to 2013, the use of warfarin at discharge among acute ischemic stroke patients with NVAF was only 19.4%.…”

Section: Discussionmentioning

confidence: 99%

Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation

Chang¹,

Dong²,

Ma³

et al. 2016

Stroke

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A trial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide. In 2008, the estimated agestandardized AF prevalence in China was 0.65%, suggesting that at least 4 million adults had AF, 1 and it was predicted that 5.2 million men and 3.1 million women aged >60 years will be affected by AF in China by 2050. 2AF increases the risk of stroke, and AF-related stroke is more fatal and disabling, compared with non-AF stroke.3 Oral anticoagulation (OAC) is recommended to reduce the risk of thromboembolic events in patients with AF with either a moderate or high risk of stroke. 4,5 Various registry studies report that nearly half to four fifths of high-risk AF patients were taking OAC therapy in developed countries 6-10 ; however, in Chinese patients with AF, OAC remains underused. 11During the past decade, the Chinese medical societies have made great efforts to improve stroke prevention among Background and Purpose-Reported rates of oral anticoagulation (OAC) use have been low among Chinese patients with atrial fibrillation (AF). With improved awareness, changing guidelines, this situation may be changing over time. We aimed to explore the current status and time trends of OAC use in Beijing. Methods-We used the data set from the Chinese Atrial Fibrillation Registry (CAFR), a prospective, multicenter, hospitalbased registry study involving 20 tertiary and 12 nontertiary hospitals in Beijing. A total of 11 496 patients with AF were enrolled from 2011 to 2014. Results-Seven thousand nine hundred seventy-seven eligible patients were included in this ancillary study.

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Section: Discussionmentioning

confidence: 99%

Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation

Chang¹,

Dong²,

Ma³

et al. 2016

Stroke

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“…Despite the high stroke incidence, only 4.1% of Chinese patients with AF are currently under warfarin therapy . Results from a recently published large‐sample study showed that AF patients taking warfarin did not have lower stroke rate compared to patients taking aspirin, probably due to a poor international standard ratio (INR) control. In non‐valvular atrial fibrillation (NVAF) patients, 90% of cases of atrial thrombi are derived from the left atrial appendage (LAA) .…”

Section: Introductionmentioning

confidence: 99%

Primary and Secondary Stroke Prevention Using Left Atrial Appendage Closure with Watchman Devices in Atrial Fibrillation Patients

Chen

Zhang

Huang

et al. 2017

Pacing Clinical Electrophis

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“…In the United States, increasing use of warfarin among patients with AF (26.7% in 1992 to 63.1% in 2007) was associated with declining trend in incidence of ischemic stroke but without any significant increase in hemorrhagic stroke rates. 8 However, warfarin is extremely underused 9,10 in Chinese patients with AF, particularly in those with a higher stroke risk. 11,12 Besides physicians' compliance with guideline recommendations for stroke prevention, 13 patients' nonadherence and nonpersistence to warfarin are major barriers to improved anticoagulation treatment in patients with AF.…”

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confidence: 99%

Long-Term Persistence of Newly Initiated Warfarin Therapy in Chinese Patients With Nonvalvular Atrial Fibrillation

Wang

et al. 2016

Circ: Cardiovascular Quality and Outcomes

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Background-Despite its therapeutic efficacy, warfarin is extremely underused in Chinese patients with nonvalvular atrial fibrillation (AF). Whether the nonpersistence of warfarin treatment contributes to its underuse is not known. The aims of this study were to determine nonpersistence rates of newly started warfarin treatment in Chinese patients with nonvalvular AF and to identify the factors associated with discontinuation of the treatment.

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Time Trends of Aspirin and Warfarin Use on Stroke and Bleeding Events in Chinese Patients With New-Onset Atrial Fibrillation

Cited by 44 publications

References 36 publications

Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation

Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation

Primary and Secondary Stroke Prevention Using Left Atrial Appendage Closure with Watchman Devices in Atrial Fibrillation Patients

Long-Term Persistence of Newly Initiated Warfarin Therapy in Chinese Patients With Nonvalvular Atrial Fibrillation

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