Time trends of polybrominated diphenylether (PBDE) congeners in serum of Swedish mothers and comparisons to breast milk data

Darnerud, Per Ola; Lignell, Sanna; Aune, Marie; Isaksson, Martin; Cantillana, Tatiana; Redeby, Johan; Glynn, Anders

doi:10.1016/j.envres.2015.02.031

Cited by 89 publications

(32 citation statements)

References 42 publications

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“…10,14 In particular, declining trends seem to be more apparent for the lower-brominated congeners with some reports of stable or even increasing trends for the higher brominated BDE-153 and BDE-209 congeners. 38–40 In our study, however, we did not see distinctly different temporal patterns for BDE-153 compared to those of the lower brominated compounds nor did we see any temporal shifts in congener profiles.…”

Section: Discussioncontrasting

confidence: 78%

Temporal Evaluation of Polybrominated Diphenyl Ether (PBDE) Serum Levels in Middle-Aged and Older California Women, 2011–2015

Hurley

Goldberg

Nelson

et al. 2017

Environ. Sci. Technol.

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In response to health concerns and widespread human exposures, two widely used commercial formulations of polybrominated diphenyl ethers (PBDEs) were banned in the United States in 2005. Initial biomonitoring data have provided early indications of reduced human exposures since these bans took effect. Our objective was to evaluate temporal trends in PBDE serum levels among a population of older California women during a four-year period, beginning approximately five years after these formulations were banned. Automated solid phase extraction and gas chromatography/high resolution mass spectrometry were used to measure PBDE levels in blood collected during 2011–2015 among 1253 women (ages 40–94) participating in the California Teachers Study. Only congeners with detection frequencies (DF) ≥ 75% were included in the present analysis: BDE-47 (DF = 88%); BDE-100 (DF = 78%); and BDE-153 (DF = 80%). Results from age- and race/ethnicity-adjusted linear regression analyses indicated modest, but statistically significant, average annual percent increases in the serum concentrations of all three PBDEs over the four-year study period. While not without limitations, these results, in the context of other biomonitoring data, suggest that earlier reported declines in PBDE levels may have plateaued and may now be starting to increase. Further biomonitoring to ascertain current trends and determinants of population exposures is warranted.

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Section: Discussioncontrasting

confidence: 78%

Temporal Evaluation of Polybrominated Diphenyl Ether (PBDE) Serum Levels in Middle-Aged and Older California Women, 2011–2015

Hurley

Goldberg

Nelson

et al. 2017

Environ. Sci. Technol.

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“…Recent data indicate that PBDEs exposure increased from the 1970s through to the early 2000s, but has recently decreased [67,68]. In the same direction were the results of a study conducted in California that compared PDBE levels in the serum of second-trimester pregnant women between 2008–2009 and a different cohort recruited in the same hospital in 2011–2012.…”

Section: Xenobioticsmentioning

confidence: 80%

Nutritional and Environmental Factors in Thyroid Carcinogenesis

Nettore

Colao

Macchia

2018

IJERPH

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Several epidemiological studies suggest an increased incidence of thyroid carcinoma (TC) in recent years, especially for the papillary histotype (PTC), suggesting that specific carcinogens might promote molecular abnormalities that are typical of PTC. The increased incidence is probably attributed to more intensive and sensitive diagnostic procedures, even if recent data suggest that various toxic elements could explain the phenomenon. Ionizing radiation exposure represents the most accepted risk factor for differentiated thyroid cancer that includes both the follicular and papillary histotypes. In this review, we examined the other environmental carcinogens that play a role in TC, such as eating habits, living in volcanic areas, and xenobiotic elements. Among eating habits, iodine intake represents one of the more discussed elements, because its deficiency is associated with follicular thyroid carcinomas (FTCs), while its progressive increment seems to be responsible for PTC. The gas, ash, and lava emissions of volcanoes are composed of various toxic compounds that pollute ground water, vegetables, and animals, contaminating humans via the food chain. Finally, the risk of developing PTC has also been associated with exposure of the population to xenobiotics in the environment or in the home. Their carcinogenic effects are probably caused by their accumulation, but additional studies are necessary to better understand the mechanisms of action.

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“…For example, the phase out of PBDE flame retardants in US and Europe has led to lower exposures in both breast milk [148] and maternal serum levels during pregnancy [82]. However, in response to the phase out, the chemical industry introduced replacement chemicals, often very similar in structure and with equal or uncharacterized toxicity; these substitutes were soon measured in pregnant women’s bodies [67, 75].…”

Section: Discussionmentioning

confidence: 99%

Cumulative Chemical Exposures During Pregnancy and Early Development

Mitro

Johnson

Zota

2015

Curr Envir Health Rpt

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Industrial and consumer product chemicals are widely used, leading to ubiquitous human exposure to the most common classes. Because these chemicals may affect developmental milestones, exposures in pregnant women and developing fetuses are of particular interest. In this review, we discuss the prevalence of chemical exposures in pregnant women, the chemical class-specific relationships between maternal and fetal exposures, and the major sources of exposures for six chemical classes of concern: phthalates, phenols, perfluorinated compounds (PFCs), flame retardants, polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCs). Additionally, we describe the current efforts to characterize cumulative exposures to synthetic chemicals during pregnancy. We conclude by highlighting gaps in the literature and discussing possible applications of the findings to reduce the prevalence of cumulative exposures during pregnancy.

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Time trends of polybrominated diphenylether (PBDE) congeners in serum of Swedish mothers and comparisons to breast milk data

Cited by 89 publications

References 42 publications

Temporal Evaluation of Polybrominated Diphenyl Ether (PBDE) Serum Levels in Middle-Aged and Older California Women, 2011–2015

Temporal Evaluation of Polybrominated Diphenyl Ether (PBDE) Serum Levels in Middle-Aged and Older California Women, 2011–2015

Nutritional and Environmental Factors in Thyroid Carcinogenesis

Cumulative Chemical Exposures During Pregnancy and Early Development

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