Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects

Trucco, Elisa M.; Yang, Songshan; Yang, James; Zucker, Robert A.; Li, Runze; Buu, Anne

doi:10.1007/s10964-019-01171-3

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…This finding may be because adolescents affiliated with deviant peers tend to be more interested in immediate pleasures than in considering the future consequences of their immediate pleasures. In contrast, adolescents with low deviant peer affiliation have good self-control, which, to some extent, can relieve the adverse influence of low consideration of future consequences [42][43][44]. Therefore, the contribution of consideration of future consequences and deviant peer affiliation to internet addiction should not be viewed independently but considered together.…”

Section: Discussionmentioning

confidence: 99%

Self-Control, Consideration of Future Consequences, and Internet Addiction among Chinese Adolescents: The Moderating Effect of Deviant Peer Affiliation

Chen

et al. 2021

IJERPH

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Although a large number of studies have indicated that self-control was an important predictive factor for adolescent internet addiction, the moderating and mediating mechanisms underlying this relationship remain unclear. To address this research gap, the present study, according to social learning theory and the organism–environment interaction theory, tested whether consideration of future consequences mediated the relation between self-control and adolescent internet addiction and whether deviant peer affiliation moderated the relationship between consideration of future consequences and internet addiction. Using longitudinal tracking (two-time points and the interval is 6 months). Three middle schools in Guangzhou were randomly selected. The participants were 1182 students ranging in age from 12 to 15 years (average age: 14.16, SD = 1.29) from three middle schools in Guangzhou (651 boys and 531 girls) in Guangdong Province. Results showed that consideration of future consequences mediated the relationship between self-control and internet addiction. Furthermore, the relationship between future consequence consideration and internet addiction was moderated by deviant peer affiliation. These findings highlighted the potential mediating role of consideration of future consequences in linking self-control to adolescent internet addiction. We also found high deviant peer affiliation weakens the protective effect of future consequence consideration on Internet addiction. This study may provide support for adolescent Internet addiction prevention and have some educational implications.

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Section: Discussionmentioning

confidence: 99%

Self-Control, Consideration of Future Consequences, and Internet Addiction among Chinese Adolescents: The Moderating Effect of Deviant Peer Affiliation

Chen

et al. 2021

IJERPH

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“…Although it is not yet clear whether mutated GABRG1 directly affects ASD pathogenesis, studies have highlighted GABA receptor genes as potentially important in ASD ( Ma et al, 2005 ): for example, GABA receptor density was found to be reduced in ASD ( Blatt et al, 2001 ). Interestingly, a GABA gene cluster on human chromosome 4 was shown to be related to vulnerability to social context in youth ( Villafuerte et al, 2014 ; Trucco et al, 2020 ), suggesting that these genes affect social functioning. Another frequently detected gene in our data was RYR2 , which is involved in calcium channel activation in the outer membrane of the endoplasmic reticulum ( George et al, 2003 ).…”

Section: Discussionmentioning

confidence: 99%

The Role of Ion Channel-Related Genes in Autism Spectrum Disorder: A Study Using Next-Generation Sequencing

Lee

Ahn

et al. 2021

Front. Genet.

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The clinical heterogeneity of autism spectrum disorder (ASD) is closely associated with the diversity of genes related to ASD pathogenesis. With their low effect size, it has been hard to define the role of common variants of genes in ASD phenotype. In this study, we reviewed genetic results and clinical scores widely used for ASD diagnosis to investigate the role of genes in ASD phenotype considering their functions in molecular pathways. Genetic data from next-generation sequencing (NGS) were collected from 94 participants with ASD. We analyzed enrichment of cellular processes and gene ontology using the Database for Annotation, Visualization, and Integrated Discovery (DAVID). We compared clinical characteristics according to genetic functional characteristics. We found 266 genes containing nonsense, frame shift, missense, and splice site mutations. Results from DAVID revealed significant enrichment for “ion channel” with an enrichment score of 8.84. Moreover, ASD participants carrying mutations in ion channel-related genes showed higher total IQ (p = 0.013) and lower repetitive, restricted behavior (RRB)-related scores (p = 0.003) and mannerism subscale of social responsiveness scale scores, compared to other participants. Individuals with variants in ion channel genes showed lower RRB scores, suggesting that ion channel genes might be relatively less associated with RRB pathogenesis. These results contribute to understanding of the role of common variants in ASD and could be important in the development of precision medicine of ASD.

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Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects

Cited by 2 publications

References 56 publications

Self-Control, Consideration of Future Consequences, and Internet Addiction among Chinese Adolescents: The Moderating Effect of Deviant Peer Affiliation

Self-Control, Consideration of Future Consequences, and Internet Addiction among Chinese Adolescents: The Moderating Effect of Deviant Peer Affiliation

The Role of Ion Channel-Related Genes in Autism Spectrum Disorder: A Study Using Next-Generation Sequencing

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