This study explores the leader-following consensus tracking control issue of multiple unmanned surface vehicles (multi-USVs) in the presence of malicious connectivity-mixed attacks in the cyber layer, and concurrent output channel noises, sensor/actuator faults, and wave-induced disturbances in the physical layer. Sensor/actuator faults are initially modeled with unified incipient and abrupt features. Additionally, connectivitymixed attacks are depicted using connectivity-paralyzed and connectivity-maintained topologies through nonoverlapping and switching iterations. The standardization and observer design in multi-USVs are incorporated to decouple the augmented dynamics and estimate unknown state, fault, and noise observations, and then a defense and fault-tolerant consensus tracking control approach is designed to accomplish the robustness to disturbances/noises, resilience to attacks, and tolerance to faults, simultaneously. The criteria for achieving leader-following exponential consensus tracking of multi-USVs with cyber-physical threats can be determined based on activation rate and attack frequency indicators. Comparative simulations outline the effectiveness and economy of the proposed defense and tolerance technique against sensor/actuator faults and cyber-attacks on multi-USVs.