Time-Zero Renal Biopsy in Living Kidney Transplantation: A Valuable Opportunity to Correlate Predonation Clinical Data With Histological Abnormalities

Mancilla, E; Ávila-Casado, Carmen; Uribe‐Uribe, Norma; Morales‐Buenrostro, Luis E.; Rodríguez, F Santos; Vilatobá, Mario; Gabilondo, Bernardo; Aburto, S; Rodriguez, R. Michael; Magana, Sergio; Magaña, Fernando González; Alberú, Josefina

doi:10.1097/tp.0b013e3181906150

Cited by 42 publications

(31 citation statements)

References 25 publications

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“…Although these studies measured the extent of IF in the cortex at several time points after transplantation, they did not report quantitative measurements of IF in donor kidney at the cold preservation time immediately before transplantation (0 hr or time-zero biopsy). Mancilla et al (8) reported that there were significant correlations between time-zero biopsy and clinical predonation parameters such as the age and serum creatinine (SCr) level of donors before transplantation. Percent IF (%IF), as a measure of the allograft cortical area affected by IF, at 0 hr may influence %IF at 1 month and 1 year posttransplantation.…”

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confidence: 99%

Factors Increasing Quantitative Interstitial Fibrosis From 0 hr to 1 Year in Living Kidney Transplant Patients Receiving Tacrolimus

et al. 2011

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confidence: 99%

Factors Increasing Quantitative Interstitial Fibrosis From 0 hr to 1 Year in Living Kidney Transplant Patients Receiving Tacrolimus

et al. 2011

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“…Although these studies are reassuring, there are two recent reports of increased preeclampsia in female living donors when adjusting for maternal age and parity (10,11). Furthermore, it has come to light that up to 50% of donor renal biopsies are not completely normal, with the most common findings being interstitial fibrosis, tubular atrophy, increased mesangial matrix, arteriolar hyalinosis, and glomerulosclerosis (12).…”

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The State of U.S. Living Kidney Donors

Davis¹,

Cooper²

2010

Clinical Journal of the American Society of Nephrology

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Conclusions: Almost one quarter of living donors have medical conditions that may be associated with future health risk. Close follow-up and a registry of these donors are necessary. Only then will we be able to inform prospective living donors most accurately of the real risk of donation on their health and survival. Additionally, these data speak to the need for a national discussion on the provision of health insurance for living donors.

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“…11,12 Biopsy is the criterion standard for defining the quality of an older kidney. However, a renal biopsy potentially can injure the kidney, leading to postoperative aneurysm formation, rupture and bleeding.…”

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confidence: 99%

Outcome of renal transplantation from older living donors compared to younger living donor in developing country

et al. 2014

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Objectives: To evaluate whether the outcomes of renal grafts from living related donors older than 60 years are acceptable, in terms of renal function and patient/graft survival. Material and methods: One hundred and forty-seven patients who received kidneys from donor age 60 years constituted the study group (group 1). The control group (group 2) consisted of 1310 patients who received renal transplants from donor age 560 years. Outcome measures included graft, patient survival, acute rejection rate and serum creatinine (SCr) in patients/ donors. Graft and patient survivals were compared using the Kaplan-Meier method. Results: The mean age of donors was 62.7 ± 3.39 years in group 1 and 43.45 ± 9.65 years in group 2. Patient survival at 1, 3 and 5 years was 95.7%, 89.4% and 82.6% in group 1 and 93.8%, 89.1% and 83.1% in group 2 (p ¼ 0.785), respectively. Death-censored graft survival at 1, 3 and 5 years was 98.5%, 94.8% and 94.8% in group 1 and 96.1%, 92.9% and 89% in group 2 (p ¼ 0.166), respectively. Biopsy-proven acute rejections were 21% and 16.8% (p ¼ 0.206) and chronic rejections 5% and 3.4% in group 1 and 2, respectively (p ¼ 0.542). Recipient SCr (mg/dL) was 1.8 ± 0.31 in group 1 and 1.58 ± 0.37 in group 2. The donor SCr levels at the last follow-up were 1 mg/dL and 0.9 mg/ dL in group 1 and 2, respectively. Conclusions: Donor age did not affect patient and graft survival in the 5-year follow-up in our study. Age alone seems not to be an exclusion criterion to living kidney donation.

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Time-Zero Renal Biopsy in Living Kidney Transplantation: A Valuable Opportunity to Correlate Predonation Clinical Data With Histological Abnormalities

Cited by 42 publications

References 25 publications

Factors Increasing Quantitative Interstitial Fibrosis From 0 hr to 1 Year in Living Kidney Transplant Patients Receiving Tacrolimus

Factors Increasing Quantitative Interstitial Fibrosis From 0 hr to 1 Year in Living Kidney Transplant Patients Receiving Tacrolimus

The State of U.S. Living Kidney Donors

Outcome of renal transplantation from older living donors compared to younger living donor in developing country

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