Timectomía en la miastenia gravis

Atance, Pablo León; Aragoneses, Federico González; Mata, Nicolás Moreno; Fontan, Élisabeth; Medina, D. León; Gómez, Jordi Marco; Palomino, E. Orusco; Gómez, E. Folqué; Blanco, J.L. Muñoz

doi:10.1016/s0300-2896(01)75060-0

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…9), and robotic assisted thoracoscopic surgery (RATS). All soft tissue should be removed in the anterior mediastinum between the phrenic nerves, which is key to control patients who present with myasthenia gravis and has been shown to positively impact mortality [17,18]. Although the standard surgical technique is median sternotomy, since it showing uniform cells, with little pleomorphism, cytoplasm in moderate quantity that form large solid nodules, separated by dense fibrous tissue.…”

Section: Discussionmentioning

confidence: 99%

Primary thymus tumors: retrospective case analysis at a reference center in Latin America, 2011–2019

et al. 2021

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Background Thymic tumors are unusual neoplasms, representing 0.2 to 1.5% of tumors in humans, but correspond to 20% of mediastinal tumors and 50% of those that occur in the anterior mediastinum. They tend to appear around the fourth and fifth decades of life without gender predilection. Up to 30% of patients are asymptomatic, therefore many are incidentally diagnosed. Radical thymectomy is the treatment of choice with high survival rates when detected in the early stages. Methods This was a retrospective descriptive study, including 18 adult patients’ diagnosis of thymic neoplasm, who were managed with surgical resection from 2011 to 2019. Information about demographics, clinical characteristics, imaging findings, surgical and medical management, plus histological findings was obtained and reported. Results 18 patients with thymic tumors were included, of which specific histologic studies reveled thymomas, carcinomas, neuroendocrine tumors, thymolipoma and thymic cyst. Mean age was 52.7 years, with a predominance of male population. The main symptom was dyspnea, followed by cough and chest pain. Paraneoplastic syndromes such as myasthenia gravis, aplastic anemia and Cushing syndrome were reported. 89% of cases were treated by radical thymectomy alone, while only 2 cases required chemotherapy and radiotherapy. There were no surgical complications. Mean hospital stay length was 11. 9 days, with only 1 mortality during hospital admission. 5-year survival rate was 81%. Conclusions The treatment of choice is radical thymectomy, which has been shown to positively impact patient mortality. Early detection is key to improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Primary thymus tumors: retrospective case analysis at a reference center in Latin America, 2011–2019

et al. 2021

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“…De nitive diagnosis was made after surgical intervention in most cases, as in our patients, since the use of biopsy is only contemplated when there is suspicion of a differential diagnosis such as germ cell tumor or goiter. [19] The World Health Organization (WHO) described a histopathological classi cation for thymomas, thymic carcinomas, thymic neuroendocrine tumors, among others. Speci cally for thymomas, which are the most frequent, they are classi ed as type A, atypical type A variant, type AB, type B1-B3, micronodular thymoma with lymphoid stroma (MNT), metaplastic thymoma and other rare thymomas such as microscopic thymoma, sclerosing thymoma and lipo broadenoma (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Primary Thymus Tumors: Retrospective Case Analysis at a Reference Center in Latin America, 2011 – 2019

Scarpetta-González

Morales

Sua

et al. 2020

Preprint

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BackgroundThymic tumors are unusual neoplasms, representing 0.2% to 1.5% of tumors in humans, but correspond to 20% of mediastinal tumors and 50% of those that occur in the anterior mediastinum. They tend to appear around the fourth and fifth decades of life without gender predilection. Up to 30% of patients are asymptomatic, therefore many are incidentally diagnosed. Radical thymectomy is the treatment of choice with high survival rates when detected in the early stages. Methods This was a retrospective descriptive study, including 18 adult patients’ diagnosis of thymic neoplasm, who were managed with surgical resection from 2011 to 2019. Information about demographics, clinical characteristics, imaging findings, surgical and medical management, plus histological findings was obtained and reported. Results18 patients with thymic tumors were included, of which specific histologic studies reveled thymomas, carcinomas, neuroendocrine tumors, thymolipoma and thymic cyst. Mean age was 52.7 years, with a predominance of male population. The main symptom was dyspnea, followed by cough and chest pain. Paraneoplastic syndromes such as myasthenia gravis, aplastic anemia and Cushing syndrome were reported. 89% of cases were treated by radical thymectomy alone, while only 2 cases required chemotherapy and radiotherapy. There were no surgical complications. Mean hospital stay length was 11. 9 days, with only 1 mortality during hospital admission. 5-year survival rate was 81%. Conclusions The treatment of choice is radical thymectomy, which has been shown to positively impact patient mortality. Early detection is key to improve patient outcomes.

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