Timed high‐fat diet resets circadian metabolism and prevents obesity

Sherman, Hadas; Genzer, Yoni; Cohen, Rotem; Chapnik, Nava; Madar, Zecharia; Froy, Oren

doi:10.1096/fj.12-208868

Cited by 325 publications

(342 citation statements)

References 41 publications

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“…Timed HF diet led to decreased body weight, cholesterol and TNFα levels and improved insulin sensitivity compared with mice fed HF diet ad libitum. Timed HF-fed mice exhibited a better satiated and less stressed phenotype of low ghrelin and corticosterone compared with mice fed timed low-fat diet [139]. In addition, timed HF diet improved metabolic pathway function and oscillations of the circadian clock and their target gene expression.…”

Section: Effect Of High-fat Diet On Circadian Rhythmsmentioning

confidence: 92%

“…It has recently been shown that long-term day-time RF can increase the amplitude of clock gene expression, increase expression of catabolic factors, and reduce the levels of disease markers leading to better health [138] (Figure 3). Moreover, timed high-fat diet led to reduced body weight and improved metabolism compared to animals that consumed the same caloric intake spread out throughout the day [139] (see below). Because timed feeding is dominant in resetting circadian rhythms even in animals with lesioned SCN, it has been suggested that there is a food-entrainable oscillator (FEO).…”

Section: Effect Of Restricted Feeding (Rf) On Circadian Rhythmsmentioning

confidence: 99%

“…Recently, it was shown that timed high-fat diet can prevent obesity [139,185]. Timed HF diet led to decreased body weight, cholesterol and TNFα levels and improved insulin sensitivity compared with mice fed HF diet ad libitum.…”

Section: Effect Of High-fat Diet On Circadian Rhythmsmentioning

confidence: 99%

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Circadian Signatures in Rat Liver: From Gene Expression to Pathways

Olds¹

2014

Sleep, Circadian Rhythms, and Metabolism

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Obesity has become a serious public health problem and a major risk factor for the development of illnesses, such as insulin resistance and hypertension. Attempts to understand the causes of obesity and develop new therapeutic strategies have mostly focused on caloric intake and energy expenditure. Recent studies have shown that the circadian clock controls energy homeostasis by regulating the circadian expression and/or activity of enzymes, hormones, and transport systems involved in metabolism. Moreover, disruption of circadian rhythms leads to obesity and metabolic disorders. Therefore, it is plausible that resetting of the circadian clock can be used as a new approach to attenuate obesity. Feeding regimens, such as restricted feeding (RF), calorie restriction (CR), and intermittent fasting (IF), provide a time cue and reset the circadian clock and lead to better health. In contrast, high-fat (HF) diet leads to disrupted circadian expression of metabolic factors and obesity. This paper focuses on circadian rhythms and their link to obesity.

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Section: Effect Of High-fat Diet On Circadian Rhythmsmentioning

confidence: 92%

Section: Effect Of Restricted Feeding (Rf) On Circadian Rhythmsmentioning

confidence: 99%

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Circadian Signatures in Rat Liver: From Gene Expression to Pathways

Olds¹

2014

Sleep, Circadian Rhythms, and Metabolism

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“…However, two recent studies have shown promising results which suggest that eating according to the same daily schedule can diminish HFD-induced obesity. Scheduled high-fat feedings for 8 h during the dark period (145) or for 4 h during the light period (146) without calorie restriction prevented obesity. These studies suggest that regulating the timing of food intake can improve the amplitude of the clock and clockcontrolled metabolic-related gene expression rhythms, nutrient utilization, energy expenditure, and insulin sensitivity.…”

Section: Food Timingmentioning

confidence: 99%

Chrono-biology, Chrono-pharmacology, and Chrono-nutrition

Tahara¹,

Shibata²

2014

J Pharmacol Sci

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Molecular mechanisms of the circadian clock systemThe circadian clock system has been widely maintained in many species, from prokaryotes to mammals. "Circadian" means "around [a] day" in Latin, and therefore "circadian rhythm" refers to a cycle of approximate 24 h. The earth rotates once every 24 h, and the circadian system has evolved to adjust functions and behavior to this cycle in order to efficiently utilize sunlight for photosynthesis in the case of plants and cyanobacteria and to obtain food in the case of animals. One of the most important features of our circadian system is that circadian clocks can endogenously maintain time under constant darkness and without external stimuli, suggesting that our body has its own internal clocks. In 1972, Moore and Eichler (1) investigated the effects of destroying the suprachiasmatic nucleus (SCN) in the rat hypothalamus. Their results revealed the loss of sleep-wake cycles and corticosterone rhythms. Since then, the SCN is regarded as the location of the master clock system in mammals. The SCN receives light-dark information directly through the retinal-hypothalamic tract and organizes the local clock in the peripheral tissues through multiple pathways involving neural and hormonal functions (2, 3). The molecular mechanism of the circadian system in mammals has been well studied over the past two decades. The transcriptional-translational feedback loop of the major clock genes Bmal1, Clock, Per1/2, and Cry1/2 is the main component of the circadian system (2) (Fig. 1A). Bmal1 and Clock, which are transcriptional activators, play a positive role in activating the Per and Cry genes through a specific promoter sequence known as the E-box. Per and Cry are translated into proteins in the cytoplasm and are then transported back into the nucleus after interacting with each other, and they subsequently stop their transcription by binding to BMAL1 and CLOCK. Thus, Per and Cry are rhythmically expressed over a 24-h period. This transcriptional regulation induces rhythmic expression of approximately 10% of all genes in each peripheral cell (4 -6). In addition to such transcriptional regulation of the circadian clock, post-transcriptional regulation and translational regulation have recently been reported to play important roles in maintaining circadian rhythms. Genome-wide RNA-seq and Chip-seq analyses found that only 22% of the rhythmically oscillating messenger RNAs are driven by de novo transcription, with RNA polymerase II recruitment and chromatin remodeling also exhibiting such rhythms (7). Furthermore, it was reported that the non-transcriptional redox cycle has a 24-h rhythm in Chrono-biology, Chrono-pharmacology, and Chrono-nutrition Tokyo 162-8480, Japan Received October 25, 2013; Accepted January 5, 2014 Abstract. The circadian clock system in mammals drives many physiological processes including the daily rhythms of sleep-wake behavior, hormonal secretion, and metabolism. This system responds to daily environmental changes, such as the light-dark cycle, food...

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“…Investigaciones previas con animales de laboratorio han mostrado que el consumo de dietas altas en grasa afecta componentes que forman parte del sistema homeostático, como el ritmo circadiano (Honma, Hikosaka, Mochizuki & Goda, 2016;Sherman et al, 2012) y la actividad espontánea de los animales (Ludmilla et al, 2017). Por ejemplo, sujetos experimentales expuestos a una dieta alta en grasa presentaron un incremento inicial de la acumulación de tejido adiposo, sin que el peso corporal aumentara significativamente; sin embargo, después de tres semanas se encontró un aumento del peso corporal e hipertrofia de los adipocitos (La Fleur, Van Rozen, Luijendijk, Groeneweg & Adan, 2010;Woods, Seeley, Rushing, D'Alessio & Tso, 2003).…”

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