Tall Fescue (Schedonorus arundinaceus) is an introduced cool-season bunch grass that is a vital component of forage systems that support beef cattle production in Missouri and much of the eastern United States. This cool-season grass is known for its high forage yield and resistance to environmental stressors such as drought, pest, and grazing. The resilience of tall fescue to stress is attributed to a symbiotic relationship with the fungal endophyte Epichloe coenophiala, which produces ergot-like alkaloids that can negatively impact livestock performance. Replacement of alkaloid producing tall fescue cultivars, such as K31, has been suggested as a strategy to reduce ergot-like alkaloid consumption by livestock; however, this requires extensive resources and time. It has been reported to cost $250 to $400 per acre to replace tall fescue, with an additional 18 months of no grazing while new species emerge. Most current research efforts have focused on managing tall fescue to reduce toxicity risk by decreasing amounts of alkaloids consumed by livestock. Removing parts of the plant, such as the stems and seedheads, that contain greater concentrations of alkaloids by physical or chemical seedhead suppression has proven to be a successful strategy. A metsulfuron herbicide and nitrogen fertilizer were applied on pastures grazed by stocker cattle for three years to evaluate impacts on toxicity and productivity of the forage system. Metsulfuron herbicide reduced seedhead density by 80 percent and decreased ergovaline production; however, this management strategy also caused a decrease in forage yield. Nitrogen fertilizer recovered forage yield losses due to metsulfuron herbicide. Seedhead reduction in response to metsulfuron has potential for reducing alkaloid exposure when grazing endophyte-infected tall fescue.