Timing and Route of Amiodarone for Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Network Regression Meta‐analysis

Chatterjee, Saurav; Sardar, Partha; Mukherjee, Debabrata; Lichstein, Edgar; Aikat, Shamik

doi:10.1111/pace.12140

Cited by 50 publications

(25 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…W większości z tych badań beta-adrenolityki podawano w okresie pooperacyjnym, a za takim schematem ich stosowania przemawia również niedawna metaanaliza [928]. W kilku metaanalizach stwierdzono, że amiodaron zmniejszał częstość występowania AF w okresie pooperacyjnym w porównaniu z beta-adrenolitykiem, a także skracał czas pobytu pacjentów w szpitalu [925,[929][930][931].…”

Section: Prewencja Migotania Przedsionków W Okresie Pooperacyjnymunclassified

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof

Benussi

Kotecha³

et al. 2016

Kardiol Pol

2,402

4,206

View full text Add to dashboard Cite

Section: Prewencja Migotania Przedsionków W Okresie Pooperacyjnymunclassified

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof

Benussi

Kotecha³

et al. 2016

Kardiol Pol

2,402

4,206

View full text Add to dashboard Cite

“…In the majority of beta-blocker studies, it is administered postoperatively [86]. Amiodarone reduced the incidence of POAF and hospital stay compared to beta-blocker therapy in several meta-analyses [86][87][88][89]. Prophylactic administration of sotalol may be considered for patients at risk of developing AF after cardiac surgery [76,90,91].…”

Section: Prevention Of Poafmentioning

confidence: 99%

Arrhythmias Post Coronary Artery Bypass Surgery

Al‐Ghamdi¹

2017

Coronary Artery Bypass Graft Surgery

View full text Add to dashboard Cite

Arrhythmias are common after cardiac surgery such as coronary artery bypass grafting surgery. Although most of these arrhythmias are transient and have a benign course, it may represent a significant source of morbidity and mortality. Postoperative arrhythmias (POAs) include atrial tachyarrhythmias, ventricular arrhythmias, and bradyarrhythmias. The incidence of POAs has not changed despite improvements in anesthetic and surgical techniques. The tachyarrhythmias in the postoperative period include atrial fibrillation, atrial flutter, supraventricular tachycardia, and ventricular tachycardia. The clinical significance of each arrhythmia depends on several factors that include cardiac function, patient's comorbidities, arrhythmia duration, and ventricular response rate. Tachycardia with uncontrolled ventricular rates can cause diastolic and later on systolic dysfunction, reduce cardiac output, and result in hypotension or myocardial ischemia. In the other hand, bradyarrhythmias may have a remarkable influence on patients with systolic or diastolic ventricular dysfunction. Arrhythmia management starts preoperatively with optimizing the patient's condition and controlling patient's risk factors, intraoperatively with careful attention to hemodynamic changes during surgery and uses appropriate anesthesia, and postoperatively with correction of temporary and correctable predisposing factors, as well as specific therapy for the arrhythmia itself. The POAs treatment urgency and management options are determined by the clinical presentation of the arrhythmia.

show abstract

“…However, this needs to be confirmed in a prospective manner. Another recent meta-analysis including 3,950 patients [58] reported that both oral and intravenous administration, as well pre- and postoperative administration, of amiodarone was effective in prevention of PoAF after cardiac surgery. Although superior to placebo in reducing the risk for PoAF, no significant superiority of amiodarone over other antiarrhythmic agents, such as beta-blockers (propranolol, metoprolol and bisoprolol) and sotalol, could be established [49,55,59].…”

Section: Pharmacological Preventionmentioning

confidence: 99%

Pharmacological strategies for prevention of postoperative atrial fibrillation

Turagam

Downey

Kress

et al. 2015

Expert Review of Clinical Pharmacology

View full text Add to dashboard Cite

Summary Atrial fibrillation (AF) complicating cardiac surgery continues to be a major problem that increases the postoperative risk of stroke, myocardial infarction, heart failure, costs and long-term survival. The incidence of AF after surgery has not significantly changed over the last two decades, despite improvement in medical and surgical techniques. The mechanism and pathophysiology underlying postoperative AF (PoAF) is incompletely understood and results from a combination of acute and chronic factors, superimposed on an underlying abnormal atrial substrate with increased interstitial fibrosis. Several antiarrhythmic and non-antiarrhythmic medications have been used for the prevention of PoAF, but the effectiveness of these strategies has been limited due to a poor understanding of the basis for the increased susceptibility of the atria to AF in the postoperative setting. In this review, we summarize the pathophysiology underlying the development of PoAF and evidence behind pharmacological approaches used for its prevention in the postoperative setting.

show abstract

Timing and Route of Amiodarone for Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Network Regression Meta‐analysis

Abstract: This systematic review suggests a regimen of both oral-only and one including IV administration, as well pre- and postoperative administration of amiodarone is effective in prevention of POAF after cardiac surgery.

Cited by 50 publications

References 39 publications

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Arrhythmias Post Coronary Artery Bypass Surgery

Pharmacological strategies for prevention of postoperative atrial fibrillation

Contact Info

Product

Resources

About