“…To deal with such safety-related challenges, there is an increasing interest in adopting agile development paradigms within the CPS safety-critical domains [6,7] to identify hazards and elicit safety requirements iteratively [8]. Consequently, researchers proposed the usage of Digital-Twins 1 technologies to simulate and test CPSs in a diversified set of scenarios [9,10,11,12,13] to support testing automation [14,15], regression testing [12,16], and debugging [17,18] activities. In this context, simulation-based testing has been suggested as a promising direction to improve the SDC testing practices [19,20,21] because simulation environments enable efficient test execution, reproducible results, and testing under critical conditions [22].…”