Timing Is Everything: The Onset of Depression and Acute Coronary Syndrome Outcome

Parker, Gordon; Hilton, Therese; Walsh, Warren F.; Owen, Catherine; Heruc, Gabriella; Olley, Amanda; Brotchie, Heather; Hadži-Pavlović, Dušan

doi:10.1016/j.biopsych.2008.05.021

Cited by 83 publications

(75 citation statements)

References 23 publications

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“…We assessed cardiac events only, producing results which were not inflated by non-cardiac Previous research has suggested that the timing of the depressive episode is relevant for prognosis. 19,50,51 This data was unfortunately unavailable in the present study, and it is therefore impossible to speculate whether symptoms of fatigue-sadness better reflect the new-onset depression which has been shown to be particularly cardiotoxic in other research.…”

Section: Limitations and Strengthsmentioning

confidence: 75%

Depressive symptoms in persons with acute coronary syndrome: Specific symptom scales and prognosis

Doyle

Conroy

McGee

et al. 2010

Journal of Psychosomatic Research

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Section: Limitations and Strengthsmentioning

confidence: 75%

Depressive symptoms in persons with acute coronary syndrome: Specific symptom scales and prognosis

Doyle

Conroy

McGee

et al. 2010

Journal of Psychosomatic Research

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“…Numerous studies have documented that depression in patients with ACS is associated with a higher incidence of mortality, recurrent cardiovascular events, and healthcare utilisation (Rozanski et al 2005). Parker et al (2008) determined that only depressive episodes that commenced after an ACS admission were associated with a poorer cardiovascular outcome. Amin et al (2008) found that reduced levels of omega-3 fatty acids in blood cell membranes, an emerging risk factor for both ACS and depression, could help explain the relationship between depression and adverse ACS outcomes.…”

Section: Depressionmentioning

confidence: 99%

Availability of highly sensitive troponin assays and acute coronary syndrome care: insights from the SNAPSHOT registry

Cullen

French

Briffa

et al. 2015

Medical Journal of Australia

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Objectives: To examine differences in care and inhospital course of patients with possible acute coronary syndrome (ACS) in Australia and New Zealand based on whether a highly sensitive (hs) troponin assay was used at the hospital to which they presented. Design, setting and patients: A snapshot study of consecutive patients presenting to hospitals in Australia and New Zealand from 14 to 27 May 2012 with possible ACS. Main outcome measures: Rates of major adverse cardiac events (inhospital death, new or recurrent myocardial infarction, stroke, cardiac arrest or worsening heart failure); association between assay type and outcome (via propensity score matching and a generalised estimating equation [GEE]; averages of the predicted outcomes among patients who were treated with and without the availability of an hs assay (via inverse probability‐weighting [IPW] with regression‐adjusted estimators). Results: 4371 patients with possible ACS were admitted to 283 hospitals. Over half of the hospitals (156 [55%]) reported using the hs assay and most patients (2624 [60%]) had hs tests (P = 0.004). Use of the hs assay was independent of hospital coronary revascularisation capability. Patients tested with the hs assay had more non‐invasive investigations (exercise tests, stress echocardiography, stress nuclear scans, and computed tomography coronary angiography) than those tested with the sensitive assay. However, there were no differences between the groups in rates of angiography or revascularisation. All adjusted analyses showed a consistently lower rate of inhospital events, including recurrent heart failure in patients for whom the hs assay was used (GEE odds ratio, 0.75; 95% CI, 0.60–0.94; P = 0.014); IPW analysis showed a 2.3% absolute reduction in these events with the use of the hs assay (P = 0.018). Conclusion: Use of hs troponin testing of patients hospitalised with possible ACS was associated with an increased rate of non‐invasive cardiac investigations and fewer inhospital adverse events.

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“…Incident post-MI depression is defined as a first-ever episode with an onset after the MI. In a recent issue of Biological Psychiatry, Parker et al (1) confirm that the association between post-MI depression and prospective cardiovascular events is due to those episodes that develop just after the cardiac event.…”

Section: Correspondence the Importance Of Incident Depression In Myocmentioning

confidence: 99%

“…Thus far, the distinction between incident depression and recurrent depression has been found helpful in distinguishing response to treatment in non-CAD depressed patients (19 -21), in which only subjects who had repeated past episodes responded to therapy. With the results presented by Parker et al (1), it is possible that in MI patients, we are currently able to effectively treat depression that is not associated with an increased risk of cardiovascular events but not depression that is associated with increased risk, as observed in the Sertraline AntiDepressant Heart Attack Trial (SADHART) (16 …”

Section: Correspondence the Importance Of Incident Depression In Myocmentioning

confidence: 99%

The Importance of Incident Depression in Myocardial Infarction Patients

Jonge

2009

Biological Psychiatry

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Timing Is Everything: The Onset of Depression and Acute Coronary Syndrome Outcome

Cited by 83 publications

References 23 publications

Depressive symptoms in persons with acute coronary syndrome: Specific symptom scales and prognosis

Depressive symptoms in persons with acute coronary syndrome: Specific symptom scales and prognosis

Availability of highly sensitive troponin assays and acute coronary syndrome care: insights from the SNAPSHOT registry

The Importance of Incident Depression in Myocardial Infarction Patients

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