Timing of cognitive effects on afterdischarge termination

Lesser, Ronald P.; Webber, W. R.; Miglioretti, Diana L.

doi:10.1016/j.clinph.2023.06.005

Cited by 1 publication

(7 citation statements)

References 24 publications

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“…This is the same data as Fig. 3 in our previous paper 7 , but with results placed on the same y-axis as the other items in this figure. The five distance groups are 0-1.9 cm, 1.9 cm-< 3.4 cm, 3.4 cm-< 5.1 cm, 5.1-< 7.…”

Section: Resultssupporting

confidence: 65%

“…The 7.13 Hz responses increased for several segments and then decreased, except for an increase for the AdE segment with respect to the closest distance group (0-1.9 cm). The overall appearances for the three middle distance groups (1.9-3.4, 3.4-5.1, 5.1-7.3 cm) were quite similar to one another, and also similar to the responses for all contact pairs (all) (also see 7 ). shows the results for all inter-contact distance pairs.…”

Section: Resultssupporting

confidence: 58%

“…We calculated WxCoh for all electrode contact pairs over a range of wavelet scales with peak frequencies from 7.13 to 40.05 Hz. These in our previous papers had been significantly associated with AD termination [5][6][7] , and spectral analysis had shown these to contain the majority of the WxCoh changes 7 . For these calculations, a scale can be thought of as a surrogate for frequency.…”

Section: Analysis Of Electrocorticographymentioning

confidence: 81%

“…Vol. :(0123456789) We analyzed several one-second segments of the ECoG recorded during the task 7 (Fig. 3).…”

Section: Clinical Testingmentioning

confidence: 99%

“…Therefore, the distance effect we found is a property of interactions throughout the cortex. Next, we separated the ECoG into five time segments occurring within the AST trial period 7 . We found progressive and significant coherence decreases over time for the 16.89, 22.53, and 30.03 Hz frequency groups, with coherence increasing with AD termination.…”

Section: Cognitive Tasks and Afterdischarge Terminationmentioning

confidence: 99%

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Pan-cortical electrophysiologic changes underlying attention

Lesser,

Webber,

Miglioretti

2024

Sci Rep

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We previously reported that pan-cortical effects occur when cognitive tasks end afterdischarges. For this report, we analyzed wavelet cross-coherence changes during cognitive tasks used to terminate afterdischarges studying multiple time segments and multiple groups of inter-electrode-con distances. We studied 12 patients with intractable epilepsy, with 970 implanted electrode contacts, and 39,871 electrode contact combinations. When cognitive tasks ended afterdischarges, coherence varied similarly across the cortex throughout the tasks, but there were gradations with time, distance, and frequency: (1) They tended to progressively decrease relative to baseline with time and then to increase toward baseline when afterdischarges ended. (2) During most time segments, decreases from baseline were largest for the closest inter-contact distances, moderate for intermediate inter-contact distances, and smallest for the greatest inter-contact distances. With respect to our patients’ intractable epilepsy, the changes found suggest that future therapies might treat regions beyond those closest to regions of seizure onset and treat later in a seizure’s evolution. Similar considerations might apply to other disorders. Our findings also suggest that cognitive tasks can result in pan-cortical coherence changes that participate in underlying attention, perhaps complementing the better-known regional mechanisms.

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Section: Resultssupporting

confidence: 65%

Section: Resultssupporting

confidence: 58%