Timing of GH Peak in Both Glucagon and Clonidine Tests is of Major Clinical Importance

Georeli, Irene; Triantafyllou, Panagiota; Dimitriadou, Meropi; Slavakis, Aristidis; Christoforidis, Athanasios

doi:10.4158/ep-2019-0089

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion2

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data confirm the observations of other studies that showed that the 60-min time point was the highest peak and had the max stimulated GH levels after CST [ 9 , 11 , 14 , 21 ].…”

Section: Discussionsupporting

confidence: 92%

Combined growth hormone stimulation testing: Could the tests be shortened?

Fatani¹

2023

Heliyon

View full text Add to dashboard Cite

“…Our data confirm the observations of other studies that showed that the 60-min time point was the highest peak and had the max stimulated GH levels after CST [ 9 , 11 , 14 , 21 ].…”

Section: Discussionsupporting

confidence: 92%

Combined growth hormone stimulation testing: Could the tests be shortened?

Fatani¹

2023

Heliyon

View full text Add to dashboard Cite

“…The study from Georeli, et al . [ 13 ] ( n = 56) and Thakur, et al . [ 14 ] ( n = 79) using CST estimated a false positive rate of 20% if peak GH levels were estimated at the abovementioned time points only.…”

Section: Discussionmentioning

confidence: 99%

Pragmatic Evaluation of Growth Hormone Stimulation Tests in Short Stature

Gupta,

Dabas,

Kohli

et al. 2024

Indian Journal of Endocrinology and Metabolism

View full text Add to dashboard Cite

Introduction: To assess the performance of growth hormone stimulation tests (GHSTs) in the evaluation of short stature. Methods: It was a single-centre retrospective study carried out in children evaluated for short stature between January 2005 to March 2020. The clonidine stimulation test (CST) and glucagon stimulation test (GST) were used to assess growth hormone (GH) reserve (GST was performed only when peak GH levels were between 5 to ≤10 ng/mL on CST). A GH level of <5 ng/mL on CST or ≤10 ng/ml on both was used to corroborate GH deficiency. Results: A total of 556 children were eligible for this study. The mean (SD) age was 12.9 (3.5) years, and 66.3% were male. The peak GH level [median (IQR)] was 5.50 ng/ml (1.90 – 7.50) on CST (at 60 minutes) and 7.45 ng/ml (2.15 – 10.77) on GST (at 120 minutes). On restricting sampling to two time points, the false positive rate was 13.6% on CST (60, 90 minutes) and 11.5% on GST (120, 150 minutes). Similarly, restricting to three time points was associated with a false positive rate of 8.5% on CST (60, 90, 120 minutes) and 3.8% on GST (90, 120, 150 minutes). Using the treating clinician-determined diagnosis of GHD as a reference standard, the optimal cut-off of peak GH on CST was 7.79 ng/ml (sensitivity: 83.8%; specificity: 89.4%). Conclusion: Restricting the GH sampling to fewer time points is associated with an increase in the false positivity rate (FPR).

show abstract

Testing for growth hormone deficiency in children

Richmond

Rogol

2020

Growth Hormone & IGF Research

View full text Add to dashboard Cite

Timing of GH Peak in Both Glucagon and Clonidine Tests is of Major Clinical Importance

Cited by 3 publications

References 26 publications

Combined growth hormone stimulation testing: Could the tests be shortened?

Combined growth hormone stimulation testing: Could the tests be shortened?

Pragmatic Evaluation of Growth Hormone Stimulation Tests in Short Stature

Testing for growth hormone deficiency in children

Contact Info

Product

Resources

About