Timing of interferon therapy and sources of infection in patients with acute hepatitis C

Viral clearance or persistence after acute hepatitis C infection: Interim results from a prospective study

“…The ALT profile during acute phase of HCV infection can be highly variable (4,13,19) and has been shown to be associated with different outcome of hepatitis C (17). A monophasic ALT profile has been reported to predict recovery, while polyphasic ALT profile is often followed by chronic evolution.…”

“…In addition, the epidemiology of the disease has changed during the past decade, and the incidence of new infections has decreased in most of the developed countries with a progressing reduction of transfusion-associated forms (6), making larger studies increasingly difficult. Accordingly, there are still a number of important unresolved issues concerning the treatment of acute hepatitis C (17,18). It is not clear yet which patients should be treated, when therapy should be started, and what regimen is optimal.…”

Survey of Dental Health Care Workers Regarding Their Knowledge of Viral Liver Disease and Prevention of Its Transmission, Using an Online Questionnaire

“…In Japan, Ogata et al [15] reported that the major sources of acute hepatitis C virus infection in 2013 were medical procedures and accidental needle sticks. Their study was a retrospective analysis of patients in 12 facilities nationwide who developed acute hepatitis C after 1990.…”

Achievement of Sustained Viral Response after Switching Treatment from Pegylated Interferon a-2b to a-2a and Ribavirin in Patients with Recurrence of Hepatitis C Virus Genotype 1 Infection after Liver Transplantation: A Case Report

“…On the other hand, we reported that mutations of the HCV core and ISDR of HCV genome were not associated with the SVR rates in our previous study [7] . It was already known that IFN monotherapy for 24 weeks is enough to eradicate HCV RNA in the case of acute hepatitis C [18][19][20] . There was no report that HCV core mutant and substitution of aa of the ISDR region affect the SVR rate in the cases of acute hepatitis C. Since recurrence of hepatitis C in LT is thought to be another acute hepatitis C, we concluded that the mutations of the HCV core and ISDR of HCV genome do not affect the SVR rate.…”