“…Aberrant motor activity in MDD includes psychomotor retardation, agitation, reductions in facial expression as well as slowing of fine motor skills, gait and speech (Krane-Gartiser et al, 2014;Lemke et al, 1999;Michalak et al, 2009;Volkers et al, 2003;Walther et al, 2011). Hand-motor tasks have been used to assess the impact of psychopharmacological treatment on motor function in depression (Hegerl et al, 2005;Mergl et al, 2007), while longitudinal changes in spontaneous motor behavior have been proven useful to monitor treatment outcomes.…”