Timing of Symptomatic Pulmonary Embolism with Warfarin Following Arthroplasty

What Is the Timing of General Health Adverse Events That Occur After Total Joint Arthroplasty?

“…This has been demonstrated on one other occasion with respect to pulmonary embolism (but not deep vein thrombosis) [22] and is confirmed here. The cause for this difference is not known.…”

“…Timing was earlier in patients undergoing TKA for pulmonary embolism (day 3 [interquartile rage 2-6] versus 5 [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], p \ 0.001) and deep vein thrombosis (day 5 [2-11] versus 13 [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], p \ 0.001) ( Table 3). Some adverse events were associated with certain baseline characteristics.…”

Low-Dose Aspirin Is Adequate for Venous Thromboembolism Prevention Following Total Joint Arthroplasty: A Systematic Review

“…Additionally, studies have indicated that the coagulation cascade may remain activated for up to 5-6 weeks after proximal femur fracture [82]. However, a study by Parvizi et al [83] showed that the highest prevalence of symptomatic VTE occurs 1 week after TJA, with approximately 94% of all VTEs occurring within only 2 weeks after surgery. Although our study did not find an association between incidence of VTE and duration of aspirin treatment, it is important to continue prophylaxis as recommended in order to avoid this devastating complication.…”

Systematic review of risk prediction scores for venous thromboembolism following joint replacement

“…The following inclusion criteria were employed for eligibility of studies: (i) population-based observational studies (prospective cohort, retrospective cohort, prospective or retrospective case control, case-cohort, or nested-case control) that developed or validated a risk prediction score for VTE or an update on a previously developed model; (ii) outcome was VTE (DVT or PE) reported in a longitudinal design (Since 90% of VTE cases occur within the first post-operative week, [16] we considered a minimum of 30 days follow-up duration as acceptable); (iii) included adults > 18 years who had been followed up after hip and/or knee replacement surgery; and (iv) RCTs that assessed the clinical effectiveness of a VTE risk prediction score in an intervention group compared to usual care in a control group. We excluded the following: (i) cross-sectional and clinical case studies; (ii) studies with risk prediction scores containing less than two variables; (iii) studies only reporting measures of associations between a potential risk factor and the risk of VTE; and (iv) studies conducted in nonpopulation-based samples.…”