Timolol-eluting graphene oxide laden silicone contact lens: Control release profile with improved critical lens properties

Maulvi, Furqan A.; Kanani, Prince A.; Jadav, Harshani J.; Desai, Bhargavi V.; Desai, Ditixa T.; Patel, Hetal; Shetty, Kiran H.; Shah, Dinesh O.; Willcox, Mark

doi:10.1016/j.jddst.2022.103134

Cited by 8 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drug-loaded soft contact lenses (SCLs) are an attractive form of ophthalmic drug delivery in pharmaceutical research ( Pereira-da-Mota et al, 2022 ; Yang and Lockwood, 2022 ) due to the potential for sustained release, improved patient compliance, increased bioavailability, and a reduction in the dose necessary to reach a therapeutic effect. Different methods for incorporating drugs into SCLs exist ( Akbari et al, 2021 ; Ciolino et al, 2016 ; Datta et al, 2022 ; Franco and De Marco, 2021 ; Hewitt et al, 2020 ; Hsu et al, 2015 ; Li et al, 2020 ; Mu et al, 2021 ; Rykowska et al, 2021 ; Silva et al, 2021a ; Silva et al, 2021b ; Xu et al, 2010 ; Zidan et al, 2021 ), such as dip-coating (soaking) ( Guo et al, 2021 ; Liu et al, 2021 ; Maulvi et al, 2022 ; Wei et al, 2021 ) and molecular imprinting ( Chu et al, 2022 ; Malaekeh-Nikouei et al, 2013 ; Raesian et al, 2021 ), but it is difficult to produce personalised doses using these techniques.…”

Section: Introductionmentioning

confidence: 99%

Inkjet drug printing onto contact lenses: Deposition optimisation and non-destructive dose verification

Pollard

Seoane-Viaño

Ong

et al. 2023

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Inkjet drug printing onto contact lenses: Deposition optimisation and non-destructive dose verification

Pollard

Seoane-Viaño

Ong

et al. 2023

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

“…GO incorporation in the direct and soaked timolol-releasing CLs led to a significant reduction in burst release and improved release profiles compared to the respective CLs without GO. This suggests that GO can effectively control the release of timolol and enhance the sustained delivery of the drug [ 82 ].…”

Section: Introductionmentioning

confidence: 99%

Recent advancements in nanomaterial-laden contact lenses for diagnosis and treatment of glaucoma, review and update

Baghban,

Talebnejad,

Meshksar

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

Despite the existence of numerous eye drops in the market, most of them are not sufficiently effective because of quick clearance and the barriers within the eye. To increase the delivery of the drugs to the eye, various new formulations have been explored in recent decades. These formulations aim to enhance drug retention and penetration, while enabling sustained drug release over extended periods. One such innovative approach is the utilization of contact lenses, which were originally designed for cosmetic purposes and vision correction. Contact lenses have appeared as a promising formulation for ocular drug delivery, as they can increase the bioavailability of drugs in the eye and diminish unwanted side effects. They are specifically appropriate for treating chronic eye conditions, making them an area of interest for researchers in the field of ophthalmology. This review outlines the promising potential of nanomaterial-laden contact lenses for diagnosis and treatment of glaucoma. It classifies therapeutic approaches based on nanomaterial type, summarizes diagnostic advances, discusses improvement of contact lenses properties, covers marketing perspectives, and acknowledges the challenges of these innovative contact lenses for glaucoma management.

show abstract

“…Our preconditions included that the technique must be practical, genuinely minimally invasive, and not leave any foreign material in the eye once delivery of the drug ends. Also, we wish to avoid covering the lesion, as would be the case if a drug-releasing contact lens system or a drug-releasing gel were used [22][23][24][25]. Based in part on our previous work with drug-loaded flexible rods, which were easy to insert and remove as they were placed in the conjunctival sac, we started developing flexible and biocompatible rod-or ring-shaped porous polymer constructs as depot/carriers.…”

Section: Introductionmentioning

confidence: 99%

Sustained Release of Voriconazole Using 3D-Crosslinked Hydrogel Rings and Rods for Use in Corneal Drug Delivery

Rakhmetova,

Yi,

Sarmout

et al. 2023

Gels

View full text Add to dashboard Cite

Corneal disorders and diseases are prevalent in the field of clinical ophthalmology. Fungal keratitis, one of the major factors leading to visual impairment and blindness worldwide, presents significant challenges for traditional topical eye drop treatments. The objective of this study was to create biocompatible 3D-crosslinked hydrogels for drug delivery to the cornea, intending to enhance the bioavailability of ophthalmic drugs. Firstly, a series of flexible and porous hydrogels were synthesized (free-radical polymerization), characterized, and evaluated. The materials were prepared by the free-radical polymerization reaction of 1-vinyl-2-pyrrolidinone (also known as N-vinylpyrrolidone or NVP) and 1,6-hexanediol dimethacrylate (crosslinker) in the presence of polyethylene glycol 1000 (PEG-1000) as the porogen. After the physicochemical characterization of these materials, the chosen hydrogel demonstrated outstanding cytocompatibility in vitro. Subsequently, the selected porous hydrogels could be loaded with voriconazole, an antifungal medication. The procedure was adapted to realize a loading of 175 mg voriconazole per ring, which slightly exceeds the amount of voriconazole that is instilled into the eye via drop therapy (a single eye drop corresponds with approximately 100 mg voriconazole). The voriconazole-loaded rings exhibited a stable zero-order release pattern over the first two hours, which points to a significantly improved bioavailability of the drug. Ex vivo experiments using the established porcine eye model provided confirmation of a 10-fold increase in drug penetration into the cornea (after 2 h of application of the hydrogel ring, 35.8 ± 3.2% of the original dose is retrieved from the cornea, which compares with 3.9 ± 1% of the original dose in the case of eye drop therapy). These innovative hydrogel rods and rings show great potential for improving the bioavailability of ophthalmic drugs, which could potentially lead to reduced hospitalization durations and treatment expenses.

show abstract

Timolol-eluting graphene oxide laden silicone contact lens: Control release profile with improved critical lens properties

Cited by 8 publications

References 46 publications

Inkjet drug printing onto contact lenses: Deposition optimisation and non-destructive dose verification

Inkjet drug printing onto contact lenses: Deposition optimisation and non-destructive dose verification

Recent advancements in nanomaterial-laden contact lenses for diagnosis and treatment of glaucoma, review and update

Sustained Release of Voriconazole Using 3D-Crosslinked Hydrogel Rings and Rods for Use in Corneal Drug Delivery

Contact Info

Product

Resources

About