1996
DOI: 10.1007/978-1-4613-0335-0_36
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TIMP-2 Mediates Cell Surface Binding of MMP-2

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Cited by 17 publications
(11 citation statements)
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“…A final step in regulating active MMPs is inhibition by small inhibitory proteins called TIMPs. MMP2 is secreted in association with TIMP2, which mediates cell surface binding of the latent complex (Corcoran et al, 1996). Several proteases, MMP2, MT1-MMP, TIMP2, and integrin ␣v␤3 were shown to colocalize in caveolae in human endothelial cells, (Puyraimond et al, 2001), and the MT1-MMP:TIMP2:MMP2: ␣v␤3 complex was shown to promote maturation of MMP2 in carcinoma cells (Deryugina et al, 2001).…”
Section: Mmp2 and Integrin ␣V␤3mentioning
confidence: 99%
“…A final step in regulating active MMPs is inhibition by small inhibitory proteins called TIMPs. MMP2 is secreted in association with TIMP2, which mediates cell surface binding of the latent complex (Corcoran et al, 1996). Several proteases, MMP2, MT1-MMP, TIMP2, and integrin ␣v␤3 were shown to colocalize in caveolae in human endothelial cells, (Puyraimond et al, 2001), and the MT1-MMP:TIMP2:MMP2: ␣v␤3 complex was shown to promote maturation of MMP2 in carcinoma cells (Deryugina et al, 2001).…”
Section: Mmp2 and Integrin ␣V␤3mentioning
confidence: 99%
“…Tumors were allowed to grow for 4 weeks until an average volume of 100 mm 3 . Loop 6 was delivered by constant infusion using a microstatic pump delivery system (Alzet, Cupertino, CA) at a dose of 2 mg/kg/day.…”
Section: Iodination and Protein Cross-linking-protein Labeling Withmentioning
confidence: 99%
“…In light of previous studies demonstrating that Loop 6 inhibits angiogenesis in vivo and the results we present here that Loop 6 binds IGF-IR and inhibits downstream signaling, we next asked whether Loop 6 could inhibit tumor growth in vivo. PC3 prostate carcinoma cells were injected subcutaneously in mice and allowed to grow until the tumors reached a volume of 100 mm 3 . The mice were then randomly assigned to two groups, and osmotic pumps containing either PBS alone or Loop 6 in PBS were implanted into the abdominal cavity.…”
Section: Loop 6 Inhibits Signaling Pathways Downstream Of the Igf-imentioning
confidence: 99%
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