Tin(IV) complexes of 2‐benzoylpyridine N(4)‐phenyl‐thiosemicarbazone: spectral characterization, structural studies and antifungal activity

N(4)-tolyl-2-benzoylpyridine thiosemicarbazones and their copper(II) complexes with significant antifungal activity: crystal structure of N(4)-para-tolyl-2-benzoylpyridine thiosemicarbazone

“…[4][5][6] The ν(C=S) absorption at 849-846 cm -1 in the spectra of the uncomplexed thiosemicarbazones is observed at 836-831 cm -1 in those of the complexes, in accordance with coordination through the sulfur. The 13-15 cm -1 shift observed upon complexation is compatible with coordination of a neutral thiosemicarbazone in all cases.…”

“…The angle between the thiosemicarbazone chain and the N(4)-phenyl ring for HL3 is smaller (11.0°) than the corresponding angle in H2Bz4Ph (16.0 o ).These differences in the angles allow shorter intermolecular distances, e.g., N(4)…N(3)_2 and N(4)…N(4)_2 which are 3.503 and 3.438 Å in HL3, and 3.717 and 3.554 Å in H2Bz4Ph. 5,16 Nevertheless, the molecular packing is almost the same in both compounds (the density values are 1.300 and 1.287 g cm -3 respectively). Both HL3 and H2Bz4Ph crystallize in the ZE configuration in relation to the C(7)-N(2) and N(3)-C(8) bonds respectively.…”

“…5 The signals in the 1 H and 13 C NMR spectra (DMSO-d 6 ) of both compounds (Tables S1 and S2, Supplementary Information) are duplicated, indicating the presence of the Z and E isomers in solution. The signal at δ = 13.03 ppm for HL3 and at δ =13.14 ppm for H2Bz4Ph 5 are characteristic of N(3)-H hydrogen bonded to the pyridine nitrogen in the Z configuration, whereas those at δ = 10.48 ppm for HL3 and at δ = 10.63 ppm for H2Bz4Ph 5 are characteristic of N(3)-H hydrogen bonded to DMSO (E configuration). 5,6,17 The Z form is predominant in solution (70%) for both compounds.…”

“…N(4)-alkyl-and N(4)-phenyl-substituted 2-benzoylpyridine thiosemicarbazones have been prepared, as well as their iron(II), palladium(II) and tin(IV) complexes. [4][5][6] Copper(II) complexes have found possible medical uses in the treatment of many diseases including cancer and microbial infections. 7 Copper(II) complexes of N(4)-substituted 2-benzoylpyridine thiosemicarbazones have been tested against the human pathogenic fungi Aspergillus niger and Paecillomyces variotii.…”

Synthesis and spectroscopic characterization of organotin(IV) complexes with 2-benzoylpyridine-N(4)-cyclohexylthiosemicarbazone (HBPCT): X-ray crystal structure of [PhSnCl2(BPCT)]

“…The bands at 280, 300 and 347 nm correspond to the n-p * transition of pyridine ring, azomethine, thiolate functions and benzene group, respectively [19]. After complexation, the UV-Vis spectra of the complexes (2-4) showed absorption bands in the region at 289-295, 306-334, 368-385 and 417-422 nm, respectively.…”