Tin

Ostrakhovitch, Elena A.

doi:10.1016/b978-012369413-3/50097-5

Cited by 10 publications

(4 citation statements)

References 207 publications

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“…Like Pb, Sn is stored in bone but inorganic Sn compounds are not well absorbed and much less toxic than Pb [ 32 ] and we found no studies investigating the relation between Sn and preeclampsia.…”

Section: Discussionmentioning

confidence: 89%

Preeclampsia and toxic metals: a case-control study in Kinshasa, DR Congo

Moyene

Scheers²,

Tandu-Umba

et al. 2016

Environ Health

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BackgroundPreeclampsia is frequent in Kinshasa (Democratic Republic of Congo), especially during the dry season. We tested whether preeclampsia was associated with exposure to environmental metals.MethodsUsing a case-control design, 88 women hospitalized with preeclampsia (cases) and 88 healthy pregnant women from the antenatal clinic (controls) were included in the study; 67 and 109 women were enrolled during the rainy and dry season, respectively. The concentrations of 24 elements were quantified by inductively coupled plasma mass spectrometry (ICP-MS) in 24-h urine collections. Differences in the urinary excretion of metals were investigated between cases and controls, and the interaction with season was assessed.ResultsCases and controls were well matched regarding age, parity and duration of pregnancy. In controls, the urinary concentrations of most elements were substantially higher than reference values for adults from industrially developed countries, e.g. for lead: geometric mean (GM) 8.0 μg/L [25th-75th percentile 3.1–13.8]. The daily urinary excretions of 14 metals were significantly higher in women with preeclampsia than in control women, e.g. for lead: GM 61 μg/day (25th–75th percentile 8–345) in women with preeclampsia vs 9 μg/day (25th–75th percentile 3–21) in controls (p < 0 · 001). A significant interaction was found between season and preeclampsia for several elements, with higher urinary excretions in preeclamptic women than controls during the dry season, but not during the rainy season.ConclusionsThis study revealed not only that women with preeclampsia excrete higher amounts of several toxic metals, especially lead, than control women, but also that this excretion exhibits seasonal variation, thus possibly explaining the high incidence and seasonal variation of preeclampsia in Kinshasa. Although the exact sources of this exposure are unknown, these findings underscore the need for preventing environmental exposures to lead and other toxic metals.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-016-0132-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 89%

Preeclampsia and toxic metals: a case-control study in Kinshasa, DR Congo

Moyene

Scheers²,

Tandu-Umba

et al. 2016

Environ Health

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“…Metallothioneins are a family of low molecular weight proteins with a unique capacity to bind seven metal ions through twenty sulfhydryl groups 5 . They have many functions, and the main one is to keep essential elements in balance.…”

Section: Blood Plasma Fractionationmentioning

confidence: 99%

“…However, like in occupational exposures, the length of exposure and species generated can lead to toxic effects. The contamination of workers and the population living near such industries can occur through inhalation of Sn dust or fumes, contact with minerals, or ingestion of water and food contaminated by the metal 5 .…”

Section: Introductionmentioning

confidence: 99%

Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry

et al. 2022

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Mining is a high-risk activity due to its dangerous processes. Tin (Sn) is obtained from cassiterite ore and mining activities expose workers to the metal. Chronic exposure to Sn may cause pneumoconiosis, gastrointestinal and hematological effects, among others. This work aimed to assess the exposure of workers to tin in a cassiterite ore processing industry, using the speciation analysis in blood plasma. Twelve subjects donated the blood samples; six were occupationally exposed to Sn. Size exclusion chromatography separated proteins in blood plasma; a graphite furnace atomic absorption spectrometer determined total tin in the plasma and eluted fractions, while SDS-PAGE determined molecular masses of proteins. Tin levels in the workers’ plasma were four times higher than in the reference individuals. After fractionation, the metal only appeared in the total inclusion volume, not being possible to confirm the binding of tin to proteins, which certainly modifies their functions and impair workers’ health. Despite that, the work process needs to change since Sn levels in the workers’ plasma pointed to metal exposure. Further works are necessary to clarify whether the metal is free or bound to small proteins in blood plasma and understand the true impact of tin on workers’ health.

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“…6 Sn( ii ) has applications in a broad spectrum of industries, including electronics, manufacturing, metallized glazing, protective coatings for food containers, and reducing agents. 7…”

Section: Introductionmentioning

confidence: 99%