Tinea capitis caused by <i>Microsporum canis</i> treated with terbinafine

Aste, Nicola

doi:10.1111/j.1439-0507.2004.01024.x

Cited by 15 publications

(3 citation statements)

References 16 publications

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“…Since TC infection is uncommon in adults, there are no widely accepted treatment guidelines. Rather, the same medications used for TC infection among children are recommended for adults at varying doses, including griseofulvin, and terbinafine, and less commonly, itraconazole and fluconazole [34,37,52,[73][74][75][76][77][78][79][80]. Regardless of the selected therapy, it is recommended to re-evaluate patients approximately one month after treatment initiation to assess for improvement [72].…”

Section: Treatment and Managementmentioning

confidence: 99%

“…Notably, the location and clinical subtype of TC infection were not associated with treatment failure or success [37]. In a retrospective study of 26 adult and pediatric patients with non-inflammatory M. canis TC confirmed by microscopy and culture, including four adult women aged 62-75 years, treated with terbinafine 250 mg/day, all adult patients achieved complete cure in 8 weeks without evidence of relapse, suggesting that a course of terbinafine for 8-12 weeks is an acceptable alternative for TC treatment in adults who have contraindications to griseofulvin [76].…”

Section: Treatment and Managementmentioning

confidence: 99%

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Comprehensive Review of Tinea Capitis in Adults: Epidemiology, Risk Factors, Clinical Presentations, and Management

Hill,

Gold,

Lipner

2024

JoF

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Tinea capitis is a fungal infection of the scalp and hair caused by dermatophyte molds, that most often affects children and may also affect adults. Previous estimates suggest that between 3% and 11% of all tinea capitis cases worldwide occur in adults, although updated epidemiological studies are needed to reassess the prevalence of tinea capitis in adult populations specifically. Postmenopausal adult women are most often affected by tinea capitis, with African American or Black women particularly at risk. Adults who experience crowded living conditions, who live in close proximity to animals, who are immunosuppressed, and/or who live in households with affected children are at greatest risk of infection. Tinea capitis can be non-inflammatory or inflammatory in nature, and the subtype affects the extent and severity of clinical symptoms. Fungal culture and potassium hydroxide preparations are the most commonly used diagnostic tools. Trichoscopy, defined as dermoscopic imaging of the scalp and hair, is a useful adjunct to the physical examination. The mainstay of therapy is oral antifungal therapy, and topical therapy alone is not recommended. Since tinea capitis infection is uncommon in adults, there are no widely accepted treatment guidelines. Rather, the same medications used for tinea capitis infection among children are recommended for adults at varying doses, including griseofulvin, and terbinafine, and, less commonly, itraconazole and fluconazole. The prognosis for tinea capitis in adults is typically excellent when prompt and adequate treatment is administered; however, delayed diagnosis or inadequate treatment can result in scarring alopecia. Over the past decade, dermatophyte infections resistant to treatment with topical and oral antifungal agents have emerged. While tinea capitis infections resistant to antifungal therapy have been rarely reported to date, antifungal resistance is rising among superficial fungal infections in general, and antifungal stewardship is necessary to ensure that resistance to treatment does not develop among dermatophytes that cause tinea capitis.

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Section: Treatment and Managementmentioning

confidence: 99%

Section: Treatment and Managementmentioning

confidence: 99%

Comprehensive Review of Tinea Capitis in Adults: Epidemiology, Risk Factors, Clinical Presentations, and Management

Hill,

Gold,

Lipner

2024

JoF

View full text Add to dashboard Cite

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“…[ 15 ] Dramatic changes in human mycoses have occurred over the last several years. [ 8 16 17 18 19 20 ] First, there has been an increase in the number of the infection cases. Second, there have been occurrences of new fungal pathogen strains as well as the expansion of more serious infection cases.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of N-Arylbenzoquinaldinium Derivatives against a Clinical Strain of M. Canis

Shchepina,

Alexandrova,

Balandina

et al. 2023

Indian Journal of Dermatology

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Background: Microsporum canis (Bodin, 1902) is a dermatophyte, which is widely represented in the developing and the developed world alike. Commonly transmitted from domestic animals it is particularly dangerous for immunosuppressed patients due to AIDS, cancer or transplant surgery. Search for new perspective antimycotic derivatives becomes an urgent task in the disease containment. Previously, several quinolinium analogs were screened for their antibacterial activity ( E. coli, St. aurous ) by our research team. Furthermore, some N- phenylbenzoquinaldinium derivatives have shown antifungal activity against Candida albicans and Candida krusei . Aims: In this study, we sought to investigate fungicidal properties of N- arylbenzoquinaldinium derivatives against a clinical strain of Microsporum canis for future medicinal applications. Materials and Methods: N- phenyl-[f]-benzoquinaldinium salts were prepared by a variation of the previously described technique and tested against a clinical strain of the fungus of Microsporum canis 114 harvested from pathogenic material of a patient (Perm, Russia, 2014). Results: N- phenyl-[f]-benzoquinaldinium tetrafluoroborate has shown antifungal activity par to (or exceeding) that of commercially available medication. Moreover, this benzoquinaldinium analog can be potentially labelled with tritium by our nuclear-chemical method, making it amenable for the sensitive pharmacokinetic studies. Conclusions: N -phenyl-[f]-benzoquinaldinium tetrafluoroborate has been shown as a promising compound for the further development of potent antifungal agents as well as radiotracers for further elucidation of biological pathways of antifungal activity.

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Systemic antifungal therapy for tinea capitis in children

González

Seaton

Bergus

et al. 2007

Cochrane Database of Systematic Reviews

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The best evidence suggests that newer treatments including terbinafine, itraconazole and fluconazole may be similar to griseofulvin in children with tinea capitis caused by Trichophyton species. Newer treatments may be preferred because shorter treatment durations may improve treatment adherence, although they may be more expensive. There is not enough evidence on the use of systemic treatments in children with Microsporum infections. Not all treatments for tinea capitis are available in paediatric formulations but all have reasonable safety profiles.

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Tinea capitis caused by Microsporum canis treated with terbinafine

Cited by 15 publications

References 16 publications

Comprehensive Review of Tinea Capitis in Adults: Epidemiology, Risk Factors, Clinical Presentations, and Management

Comprehensive Review of Tinea Capitis in Adults: Epidemiology, Risk Factors, Clinical Presentations, and Management

Antifungal Activity of N-Arylbenzoquinaldinium Derivatives against a Clinical Strain of M. Canis

Systemic antifungal therapy for tinea capitis in children

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