Non-Suicidal Self-Injurious Behavior (NSSI) among adolescents has been reported as an increasingly concerning global health issue. This study was conducted to examine the relationship between resilience and loneliness with NSSI behavior among adolescents in Johor. Additionally, the study aimed to identify the levels of resilience, loneliness, and NSSI behavior among adolescents in Johor Bahru. A convenience sampling method was used to gather data, and a total of 109 adolescents from a secondary school in the Johor Bahru district, Johor, participated in this study. The results of the study revealed that types of NSSI behaviors, such as scratching the body to the point of injury, forcefully pinching body parts, and forcefully pulling hair, were frequently performed by the respondents. The study also showed that the respondents had moderate levels of resilience, while loneliness and NSSI behavior were at low levels. Furthermore, the study results indicated a significant positive relationship between loneliness and NSSI behavior, while there was a significant negative relationship between resilience and NSSI behavior. Several suggestions and limitations of the study have been proposed for future researchers based on the findings of this study.