Tingkat kepatuhan pasien HIV/AIDS terhadap penggunaan obat anti retroviral (ARV) di RSUD Gunung Jati Cirebon

Hidayati, Nur Rahmi; Setyaningsih, Indah; Pandanwangi, Siti

doi:10.20885/jif.vol14.iss2.art1

Cited by 6 publications

(3 citation statements)

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“…Hanya saja terapi yang biasanya digunakan untuk menekan perkembangan virus dalam tubuh yaitu dengan menggunakan obat-obatan Antiretroviral (ARV) seperti Lamivudin dan Zidovudin yang harus dikonsumsi seumur hidup. [4] Akibat permasalahan kasus infeksi HIV ini mendorong kita untuk mencari solusi dan alternatif yang tepat untuk penanganannya. salah satunya dengan memanfaatkan sumber daya alam yang ada.…”

Section: Latar Belakangunclassified

Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

Azriz,

Ibrahim,

Maulana

et al. 2024

SCRIPTA SCORE Sci Med J.

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Background: Human Immunodeficiency Virus (HIV) infection is an unresolved health problem in various countries. Indonesia is rich in various potential natural resources and is able to support the development of HIV therapy through the use of bioactive components from plants, one of which is flavonoid compounds which need to be investigated for their potential anti-HIV activity. Objective: To determine the anti-HIV potential of natural compound flavonoids. Method: The method used is a narrative literature review, with literature collection obtained from PubMed, ScienceDirect and Google Scholar. The selected articles are those published in the last ten years (2013-2022) and full text is available. Result and Discussion: 24 articles included related to flavonoid and HIV. Indonesia is in an emergency situation for HIV infection, antiretroviral drugs (ARV) can only inhibit the development of the virus, but do not kill the virus directly. The antiviral potential of flavonoid compounds makes this substance an opportunity to be studied in HIV infection. The flavonoid subclasses myricetin, herbacitrin, and chalcone have the best anti-HIV activity. The natural ingredient that has the highest flavonoid such as sea fern spores, dragon fruit with a content of 0.14 - 0.15 mg/g, Moringa leaves with a content of 7.79 mg/g, and cinnamon with a fairly high content. Conclusion: Flavonoids have anti-HIV potential with different mechanisms according to the type of flavonoid compounds contained. Flavonoids are mostly contained in sea fern spores, and are also found in dragon fruit, cinnamon and Moringa leaves, which are natural ingredients that are easily available every day. Latar Belakang: Infeksi Human Immunodeficiency Virus (HIV) merupakan masalah kesehatan yang belum terselesaikan pada berbagai negara di dunia. Indonesia merupakan negara yang kaya akan berbagai sumber daya alam yang potensial dan mampu mendukung pengembangan terapi HIV melalui pemanfaatan komponen bioaktif dari tumbuhan, salah satunya adalah senyawa flavonoid yang perlu ditelitipotensi aktivitas anti-HIVnya. Tujuan: Mengetahui potensi anti-HIV dari senyawa flavonoid bahan alam Metode: Metode yang digunakan adalah tinjauan literatur naratif, dengan pengumpulan literatur dilakukan melalui database PubMed, ScienceDirect, dan Google Scholar. Artikel yang dipilih adalah yang terbit sepuluh tahun terakhir (2013-2022) dan tersedia full text. Pembahasan: 24 artikel didapatkan membahas flavonoid dan kaitannya pada HIV. Indonesia berada dalam kondisi darurat infeksi HIV, obat antiretroviral (ARV) hanya dapat menghambat perkembangan virus, namun tidak membunuh virus secara langsung. Adanya potensi antivirus dari senyawa flavonoid menjadikan zat ini berpeluang untuk diteliti pada penyakit infeksi HIV. Flavonoid subkelas myricetin, herbacitrin, dan kalkon memiliki aktivitas anti-HIV yang paling baik. Bahan alam yang mempunyai kandungan flavonoid tertinggi di antaranya spora paku laut, buah naga dengan kandungan sebesar 0,14 – 0,15 mg/g, daun kelor dengan kandungan sebesar 7,79 mg/g, dan kayu manis dengan kandungan cukup tinggi. Kesimpulan: Flavonoid memiliki potensi anti-HIV dengan mekanisme yang berbedabeda sesuai dengan jenis senyawa flavonoid yang terkandung. Flavonoid paling banyak terkandung dalam spora paku laut, serta juga ditemukan pada buah naga, kayu manis, dan daun kelor yang merupakan bahan alam yang mudah didapatkan sehari-hari.

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Section: Latar Belakangunclassified

Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

Azriz,

Ibrahim,

Maulana

et al. 2024

SCRIPTA SCORE Sci Med J.

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“…Consumption of ARV must be according to the dose and time continuously erased because non-adherence to ARV or stopping ARV therapy can cause the body of PLHIV to experience resistance to ARV it can increase the risk of HIV / AIDS infection, as well as high mortality of PLHIV. Based on a study conducted by Hidayati et al (2018), it was found that the compliance rate of high ARV consumption was 44%, while as many as 34.7% were included in the moderate level category and as many as 21.3% in the low category (Hidayati et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Qualitative Study of Factors Influencing Adherence of People With HIV/AIDS in ARV Consumption in Cilacap Regency

Johariyah,

Apriani

2023

MTPHJ

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The quality of life of HIV/AIDS people depends on the consumption of antiretroviral drugs. The viral load control response of 85% requires a commitment of 90-95% drug use. If the patient takes ARV 60 times a month, the patient does not miss more than 3 doses. The study aimed to look for factors influencing the compliance of People living with HIV/AIDS with ARV consumption. The research was conducted through qualitative research through in-depth interviews as a data collection technique for five PLHIV and their families, and interviews with peer group support, the Management of the Cilacap Regency AIDS Mitigation Commission, and the Head of VCT Cilacap Hospital carried out triangulation. Data processing techniques were carried out using thematic analysis. Based on the analysis results, 4 themes were obtained: factors that affect the compliance of PLHIV in ARV consumption as follows: internal factors: 1) Reluctance to drink because of boredom; 2). Irregularity of drinking due to forgetfulness; 3). Unwillingness to take ARV because they feel no complaints and external factors: 4) There is still a stigma against PLHIV in the community.

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“…Previous studies revealed optimal compliance in Indonesia are still below 80%. [1][2][3] Thus resulted in increasing the incidence of intestinal protozoa infections, leading to faster AIDS development, drug resistance, and treatment failure. 4,5 Based on the Situation Report on the Development of HIV-AIDS in Indonesia, July -September 2016, DKI Jakarta Province ranked in the 5th province with the highest incidence of new HIV infections and AIDS so it requires health care facilities that are able to reach people who need HIV services and ARV therapy, both public or private health care facilities.…”

Section: Introductionmentioning

confidence: 99%

Compliance With Antiretroviral Therapy Among MSM at Clinic X, Jakarta

Nafisah¹

2020

kespro

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Abstrak Latar belakang: Kepatuhan terapeutik di Indonesia masih di bawah 80 persen dan dapat mengakibatkan peningkatan insidensi infeksi usus protozoanal, perkembangan AIDS yang lebih cepat, resistensi obat, kegagalan pengobatan, dan penularan virus ke orang lain. Tujuan: Tujuan penelitian ini adalah untuk menggambarkan kepatuhan terhadap terapi antiretroviral pada LSL yang mencari pengobatan di klinik swasta dan menyelidiki faktor pendukung dan hambatan untuk retensi ART. Metode: Penelitian ini menggunakan metode penelitian kualitatif dan data yang dikumpulkan melalui wawancara mendalam. Subjek penelitian dipilih dengan menggunakan purposive sampling. Data dianalisis menggunakan analisis isi. Hasil: Informan berjumlah 7 orang, 4 ODHA, dan 3 petugas kesehatan. Hasilnya menunjukkan bahwa sebagian besar ODHA patuh dalam menggunakan terapi ARV dan mengikuti saran dokter. Faktor-faktor yang mendukung kepatuhan terhadap terapi ARV meliputi tingkat pendidikan, akses informasi, motivasi internal, hubungan pasien dengan dokter, dan dukungan sosial. Hoax, faktor yang terkait dengan pekerjaan, dan stigma adalah hambatan bagi orang yang hidup dengan HIV dalam mempertahankan kepatuhan terhadap terapi ARV. Kesimpulan: Kepatuhan optimal terhadap terapi ARV perlu dipertahankan dan ditingkatkan karena dinamis dan dipengaruhi oleh berbagai faktor. Intervensi berbasis teknologi direkomendasikan dalam memantau kepatuhan ODHA dalam terapi ARV. Kata Kunci: kepatuhan, terapi antiretroviral, hambatan, LSL, ODHA. Abstract Background: Therapeutic compliance in Indonesia was still below 80 percent and may resulted in increased incidence of protozoanal intestinal infection, faster AIDS progression, drug resistance, treatment failure, and transmission of the virus to others. Objective: The purpose of this study was to describe adherence to antiretroviral therapy among MSM who seek treatment at private clinics and investigate facilitators and barriers to ART retention. Method: This study used qualitative research methods and data collected through in-depth interview. The study subjects were selected using a purposive sampling. Data were analyzed using content analysis. Results: The informants were 7 people include 4 PLWHA and 3 health workers. The results showed that most ODHA were compliant in taking ARV therapy and following doctor's advice. Factors supported adherence to ARV therapy include levels of education, access to information, internal motivation, patient relationships with doctors, and social support. Hoaxes, work related factors, and stigma are barriers to people living with HIV in sustaining ARV therapy adherence. Conclusion: Optimal adherence to ARV therapy needs to be maintained and improved because it is dynamic and influenced by various factors. Technological interventions are recommended in monitoring PLWHA compliance in ARV therapy Keywords: adherence, antiretroviral therapy, barriers, MSM, PLWHA.

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Tingkat kepatuhan pasien HIV/AIDS terhadap penggunaan obat anti retroviral (ARV) di RSUD Gunung Jati Cirebon

Cited by 6 publications

References 1 publication

Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

Qualitative Study of Factors Influencing Adherence of People With HIV/AIDS in ARV Consumption in Cilacap Regency

Compliance With Antiretroviral Therapy Among MSM at Clinic X, Jakarta

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