The aim of this research was to know the effects of giving curcuma flour (Curcuma zanthorrhiza) and betaine in lactating rabbits on mortality and weight of weaning rabbits (weaned 2 months). The research was carried out in April – June 2021 at the Rabbit Livestock Production Laboratory, Faculty of Animal Husbandry, Padjadjaran University. This study used 18 New Zealand White rabbits with an average weight of 1.5 kg. The experimental method was used with Completely Randomized Design (CRD) with consisted of three treatments and six repetitions. The treatments consisted of P0 = basal diet containing 0,8% curcuma flour, P1 = basal diet + betaine 0,05%, and P2 = basal diet + betaine 0.1%. Data were analyzed by analysis of variance and Duncan’s multiple range test. The results showed that the addition of curcuma flour and betaine had a significant effect on the mortality rate and weaning weight of rabbits. The use of betaine 0.1% to the rabbit diet resulted in the lowest mortality rate (5.56%) and the higher weaning weight (1,164.85 grams).