Tinnitus and stress in adults: a scoping review

Elarbed, Asma; Fackrell, Kathryn; Baguley, David; Hoare, Derek J.

doi:10.1080/14992027.2020.1827306

Cited by 45 publications

(35 citation statements)

References 111 publications

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“…Patients' pre-existing history of atopy (case 2) and autoimmune disorders (cases 1 and 3) may have increased the likelihood of a dysregulated autoimmune response. On the other hand, an immunisation anxiety-related reaction can be postulated, as anxiety has also been related to the severity and persistency of tinnitus (Elarbed et al 2021). Autoimmune inner ear disease also has to be considered in the differential diagnosis, although it typically differs in clinical presentation (Ciorba et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Tinnitus following COVID-19 vaccination: report of three cases

Parrino

Frosolini

Gallo

et al. 2021

International Journal of Audiology

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Objective: To ensure the safety and quality of vaccines, especially the newest RNA-vaccines against COVID-19, is one of the World Health Organization's current highest priorities. Design: Case description. Study sample: We report three cases of sudden unilateral tinnitus following BNT162b2 mRNA-vaccine injection, which rapidly resolved in 2 out of 3 cases. Results: The mechanism responsible for its development remains unclear. A hypersensitivity reaction with an abnormal autoimmune response or a vasculitic event may be implicated. Conclusions: Large-scale and well-designed studies are needed to improve surveillance of the COVID-19 vaccine and better define possible adverse reactions involving the cochleo-vestibular system and/or immunisation anxiety-related reactions.

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Section: Discussionmentioning

confidence: 99%

Tinnitus following COVID-19 vaccination: report of three cases

Parrino

Frosolini

Gallo

et al. 2021

International Journal of Audiology

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“…An immune-mediated mechanism has been postulated, since coronaviruses are known to be neurotrophic and may cause peripheral nerves' disorders and/or central nervous system manifestations [6] , [7] . Secondly, the long-lasting COVID-19 pandemic and related psychological distress might precipitate tinnitus and peripheral vestibular disorders in susceptible patients [8] , [9] , [10] . These aspects may potentially have increased the number of patients seen for acute cochleo-vestibular impairment due to patients' urgency and concern of the diagnosis, in contrast to what was observed in the earliest stages of the pandemic.…”

Section: Introductionmentioning

confidence: 99%

Sudden hearing loss and vestibular disorders during and before COVID-19 pandemic: An audiology tertiary referral centre experience

Parrino¹,

Frosolini²,

Toninato³

et al. 2022

American Journal of Otolaryngology

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Purpose During the Coronavirus disease 2019 (COVID-19) pandemic a reduction in the diagnosis of many otorhinolaryngological and audiological disorders has been widely reported. The main aim of this investigation was to evaluate the impact of COVID-19 outbreak on the incidence of acute hearing and vestibular disorders. Materials and methods A retrospective analysis was performed of all patients evaluated in an audiology tertiary referral centre for acute cochleo-vestibular impairment between March 1st 2020 and February 28th 2021 (Pandemic Year Period, PYP). Results were compared to patients presenting with the same disorders during two previous periods (March 1st 2019 to February 29th 2020 and March 1st 2018 to February 28th 2019; First Precedent Year Period, FPYP and Second Precedent Year Period, SPYP, respectively). Results The annual incidence of total acute audio-vestibular disorders (number of annual diagnoses divided by total number of annual audiological evaluations) was 1.52% during the PYP, 1.31% in FPYP and 1.20% in SPYP. Comparison between the pandemic period and previous periods did not show a significant difference ( p > 0.05). The overall incidence of SSNHL and combined acute cochlear-vestibular involvement was significantly higher during the PYP compared to the previous periods ( p = 0.022). Conclusions There were no differences in the absolute number of acute audio-vestibular disorders during the pandemic compared to previous periods. Although not significant, the SSNHL during the pandemic appeared worse in terms of pure-tone average with a higher incidence of associated vestibular involvement. Further studies are needed to clarify the role of SARS-CoV-2 on audio-vestibular disorders incidence and pathophysiology.

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“…A strong link between tinnitus and stress has been found epidemiologically, and is seen in clinical practice; patients often report tinnitus onset or increased tinnitus severity in response to stressful events ( 94 ). People with tinnitus display dysfunction in both the short-term stress response mediated by the sympathetic nervous system, and the long-term stress response mediated by the hypothalamic pituitary adrenal axis ( 105 ).…”

Section: Resultsmentioning

confidence: 99%

“…BP, ECG, and EEG along with many other objective physiological, or psychological, function tests can be undertaken in the field, in ecologically valid settings (91,92). Although there is no single physiological objective measure of tinnitus itself, years of lab based search has identified many related markers of tinnitus related activity, for example neural networks associated with tinnitus (93), measures of emotion, and stress (94). New miniaturized wearable technology is now available to make longitudinal measures of physiological function (95)(96)(97)(98)(99)(100)(101)(102)(103)(104) that can be related to behavioral indices of tinnitus.…”

Section: Biosensorsmentioning

confidence: 99%

A State-of-Art Review of Digital Technologies for the Next Generation of Tinnitus Therapeutics

Searchfield

Sanders

Doborjeh

et al. 2021

Front. Digit. Health

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Background: Digital processing has enabled the development of several generations of technology for tinnitus therapy. The first digital generation was comprised of digital Hearing Aids (HAs) and personal digital music players implementing already established sound-based therapies, as well as text based information on the internet. In the second generation Smart-phone applications (apps) alone or in conjunction with HAs resulted in more therapy options for users to select from. The 3rd generation of digital tinnitus technologies began with the emergence of many novel, largely neurophysiologically-inspired, treatment theories that drove development of processing; enabled through HAs, apps, the internet and stand-alone devices. We are now of the cusp of a 4th generation that will incorporate physiological sensors, multiple transducers and AI to personalize therapies.Aim: To review technologies that will enable the next generations of digital therapies for tinnitus.Methods: A “state-of-the-art” review was undertaken to answer the question: what digital technology could be applied to tinnitus therapy in the next 10 years? Google Scholar and PubMed were searched for the 10-year period 2011–2021. The search strategy used the following key words: “tinnitus” and [“HA,” “personalized therapy,” “AI” (and “methods” or “applications”), “Virtual reality,” “Games,” “Sensors” and “Transducers”], and “Hearables.” Snowballing was used to expand the search from the identified papers. The results of the review were cataloged and organized into themes.Results: This paper identified digital technologies and research on the development of smart therapies for tinnitus. AI methods that could have tinnitus applications are identified and discussed. The potential of personalized treatments and the benefits of being able to gather data in ecologically valid settings are outlined.Conclusions: There is a huge scope for the application of digital technology to tinnitus therapy, but the uncertain mechanisms underpinning tinnitus present a challenge and many posited therapeutic approaches may not be successful. Personalized AI modeling based on biometric measures obtained through various sensor types, and assessments of individual psychology and lifestyles should result in the development of smart therapy platforms for tinnitus.

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Tinnitus and stress in adults: a scoping review

Cited by 45 publications

References 111 publications

Tinnitus following COVID-19 vaccination: report of three cases

Tinnitus following COVID-19 vaccination: report of three cases

Sudden hearing loss and vestibular disorders during and before COVID-19 pandemic: An audiology tertiary referral centre experience

A State-of-Art Review of Digital Technologies for the Next Generation of Tinnitus Therapeutics

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