Tinnitus in Migraine: An Allodynic Symptom Secondary to Abnormal Cortical Functioning?

Volcy, Michel; Sheftell, Fred D.; Tepper, Stewart J.; Rapoport, Alan M.; Bigal, Marcelo E.

doi:10.1111/j.1526-4610.2005.05193_2.x

Cited by 32 publications

(33 citation statements)

References 39 publications

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“…This interpretation may be supported by the observations of other authors, who described tinnitus in three migraine patients in whom tinnitus occurred during the course of a migraine attack and increased in intensity in proportion to the severity of pain [12]. …”

Section: Discussionsupporting

confidence: 70%

Tinnitus in postherpetic neuralgia

Marinis

Santilli

2009

J Headache Pain

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We describe a woman who developed postherpetic neuralgia (PHN) located on the skin areas of the left ophthalmic division of the fifth cranial nerve without ocular involvement. PHN was associated with tinnitus, which was located ipsilaterally to the painful side and increased in proportion to the intensity of pain. Tinnitus was responsive to treatment with duloxetine, 60 mg daily, and subsided when the PHN resolved. This is the first description of tinnitus in PHN.

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Section: Discussionsupporting

confidence: 70%

Tinnitus in postherpetic neuralgia

Marinis

Santilli

2009

J Headache Pain

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“…In contrast, photophobia as a symptom of the VS syndrome might be perpetuated by comorbid migraine in a non‐pain‐mediated manner. This is less clear for tinnitus, which is not a classical migrainous symptom although migraine attack‐associated episodes of tinnitus have been reported . Tinnitus could be interpreted as noise within the acoustic system.…”

Section: Discussionmentioning

confidence: 77%

The Relation Between Migraine, Typical Migraine Aura and “Visual Snow”

et al. 2014

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Objective.-To assess the relationship between the phenotype of the "visual snow" syndrome, comorbid migraine, and typical migraine aura on a clinical basis and using functional brain imaging.Background.-Patients with "visual snow" suffer from continuous TV-static-like tiny flickering dots in the entire visual field. Most patients describe a syndrome with additional visual symptoms of the following categories: palinopsia ("afterimages" and "trailing"), entopic phenomena arising from the optic apparatus itself (floaters, blue field entoptic phenomenon, photopsia, self-light of the eye), photophobia, nyctalopia (impaired night vision), as well as the non-visual symptom tinnitus. The high prevalence of migraine and typical migraine aura in this population has led to the assumption that "visual snow" is caused by persistent migraine aura. Due to the lack of objective measures, alternative diagnoses are malingering or a psychogenic disorder.Methods.-(1) The prevalence of additional visual symptoms, tinnitus, and comorbid migraine as well as typical migraine aura was assessed in a prospective semi-structured telephone interview of patients with "visual snow." Correlations were calculated using standard statistics with P < .05 being considered statistically significant. (2) Areas with increased brain metabolism in a group of "visual snow" patients in comparison to healthy controls were identified using [ 18 F]-2-fluoro-2-deoxy-Dglucose positron emission tomography and statistical parametric mapping (SPM8 with whole brain analysis; statistical significance was defined by P < .001 uncorrected for multiple comparisons).Results.-(1) Of 120 patients with "visual snow," 70 patients also had migraine and 37 had typical migraine aura. Having comorbid migraine was associated with an increased likelihood of having palinopsia (odds ratio [OR] 2.8; P = .04 for "afterimages" and OR 2.6; P = .01 for "trailing"), spontaneous photopsia (OR 2.9; P = .004), photophobia (OR 3.2; P = .005), nyctalopia (OR 2.7; P = .01), and tinnitus (OR 2.9; P = .006). Typical migraine aura was associated with an increased likelihood of spontaneous photopsia (OR 2.4; P = .04). (2) After adjusting for typical migraine aura, comparison of 17 "visual snow" patients with 17 age and gender matched controls showed brain hypermetabolism in the right lingual gyrus (Montreal Neurological Institute coordinates 16-78-5; k E = 101; ZE = 3.41; P < .001) and the left cerebellar anterior lobe adjacent to the left lingual gyrus (Montreal Neurological Institute coordinates -12-62-9; kE = 152; ZE = 3.28; P = .001).Conclusions.-Comorbid migraine aggravates the clinical phenotype of the "visual snow" syndrome by worsening some of the additional visual symptoms and tinnitus. This might bias studies on "visual snow" by migraineurs offering study participation more likely than non-migraineurs due to a more severe clinical presentation. The independence of entoptic phenomena from comorbid migraine indicates "visual snow" is the main determinant. The hypermetabolic lingual gyrus c...

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“…Central nervous system sensitization, which is characterized by photophobia, phonophobia, and osmophobia, would be a reasonable explanation for the disease 6 . Moreover, it is presumed that abnormal auditory cortex functioning due to a central and/or peripheral nervous system sensitization, and cortical hyperactivity, presumably contributes to the development of tinnitus in patients with migraine and predisposition to developing central sensitization 7 …”

mentioning

confidence: 99%

Change of Excitability in Brainstem and Cortical Visual Processing in Migraine Exhibiting Allodynia

Shibata¹,

Yamane²,

Iwata³

2006

Headache

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For BR, there were no significant differences in the ratio of the area of the R2 between the sides of stimulation, and the sides of headache. AM patients had less suppression of the R2 at the ISI of 150 and 300 ms when compared with the NA patients and HS. For PVEP, at 0.5, there were significant differences of amplitude between AM patients and HS, and between NA patients and HS in low and high contrast. At 4.0 cpd, there were significant differences of amplitude between AM patients and HS in low contrast, and between AM patients and HS, and NA patients and HS in high contrast. In AM patients, there was a significant difference of amplitude ratio between 0.5 and 4.0 cpd. Conclusions.-Our BR and PVEP study showed that migraine patients exhibiting allodynia may show central sensitization of brainstem trigeminal neuron and have contrast modulating dysfunction during the cortical visual processing of striate and extrastriate on visual cortex in-between attacks.

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Tinnitus in Migraine: An Allodynic Symptom Secondary to Abnormal Cortical Functioning?

Cited by 32 publications

References 39 publications

Tinnitus in postherpetic neuralgia

Tinnitus in postherpetic neuralgia

The Relation Between Migraine, Typical Migraine Aura and “Visual Snow”

Change of Excitability in Brainstem and Cortical Visual Processing in Migraine Exhibiting Allodynia

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