Tinnitus is Modulated by Migraine

Abouzari, Mehdi; Djalilian, Hamid R.

doi:10.1097/01.hj.0000991288.00474.2a

The Hearing Journal

2023

DOI: 10.1097/01.hj.0000991288.00474.2a

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Tinnitus is Modulated by Migraine

Mehdi Abouzari,

Hamid R. Djalilian

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2024

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Cited by 1 publication

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Efficacy of Nortriptyline‐Topiramate and Verapamil‐Paroxetine in Tinnitus Management: A Randomized Placebo‐Controlled Trial

Abouzari,

Tawk,

Kim

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveTo evaluate the efficacy of 2 drug combinations on tinnitus severity and associated stress, depression, sleep, and anxiety.Study DesignA randomized, double‐blind, placebo‐controlled clinical trial conducted between 2019 and 2023 for an 8‐week duration.SettingSingle institution tertiary care center.MethodsThe study recruited adult patients with moderate to severe tinnitus for 6 months or more. In total, 81 patients were assessed for eligibility, 78 were enrolled and randomized, and 67 were included in the per‐protocol analysis. Patients were randomized into 3 groups (1:1:1). Group NT received nortriptyline‐topiramate, group VP received verapamil‐paroxetine, and group P received placebo.ResultsA total of 19 patients in group NT, 22 in group VP, and 26 patients in group P were included in the per‐protocol analysis. In group NT, the Tinnitus Functional Index (TFI) score decreased from 58.4 ± 13.9 (baseline) to 46.3 ± 17.5 (end‐of‐trial) (P < .001). Similarly, in group VP, the TFI score decreased from 54.6 ± 17.5 to 42.2 ± 16.1 (P = .004). However, group P did not demonstrate any significant decrease in the TFI score from 51.2 ± 18.6 to 45.2 ± 20.1 (P = .086). The between‐arm analysis did not yield any statistical significance decrease in the TFI score (analysis of variance, P = .265).ConclusionBoth combinations of drugs were promising in improving tinnitus severity. However, larger‐scale trials with longer follow‐up periods are warranted to validate our findings between groups.

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Efficacy of Nortriptyline‐Topiramate and Verapamil‐Paroxetine in Tinnitus Management: A Randomized Placebo‐Controlled Trial

Abouzari,

Tawk,

Kim

et al. 2024

Otolaryngol.--head neck surg.

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show abstract

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Tinnitus is Modulated by Migraine

Cited by 1 publication

References 24 publications

Efficacy of Nortriptyline‐Topiramate and Verapamil‐Paroxetine in Tinnitus Management: A Randomized Placebo‐Controlled Trial

Efficacy of Nortriptyline‐Topiramate and Verapamil‐Paroxetine in Tinnitus Management: A Randomized Placebo‐Controlled Trial

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