Tinnitus—on the interplay between emotion and cognition. German version

Dobel, Christian; Junghöfer, Markus

doi:10.1007/s00106-023-01338-2

Cited by 1 publication

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, no hypothesis to date has fully explained the onset and progression of this disease, and the specific underlying neural mechanisms remain unclear. Over a prolonged time period, tinnitus may cause emotional and cognitive problems in some individuals, such as anxiety, depression, sleep disorders, attention deficits, and memory impairment (Dobel & Junghöfer, 2023 ; Durai & Searchfield, 2016 ), all of which can aggravate the distress patients experience, leading to a vicious cycle that severely affects their quality of life.…”

Section: Introductionmentioning

confidence: 99%

Amygdala structural and functional reorganization as an indicator of affective dysfunction in patients with tinnitus

Huang,

Chen,

et al. 2024

Human Brain Mapping

View full text Add to dashboard Cite

The aim of this study was to systematically investigate structural and functional alterations in amygdala subregions using multimodal magnetic resonance imaging (MRI) in patients with tinnitus with or without affective dysfunction. Sixty patients with persistent tinnitus and 40 healthy controls (HCs) were recruited. Based on a questionnaire assessment, 26 and 34 patients were categorized into the tinnitus patients with affective dysfunction (TPAD) and tinnitus patients without affective dysfunction (TPWAD) groups, respectively. MRI‐based measurements of gray matter volume, fractional anisotropy (FA), fractional amplitude of low‐frequency fluctuations (fALFF), regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC) were conducted within 14 amygdala subregions for intergroup comparisons. Associations between the MRI properties and clinical characteristics were estimated via partial correlation analyses. Compared with that of the HCs, the TPAD and TPWAD groups exhibited significant structural and functional changes, including white matter integrity (WMI), fALFF, ReHo, DC, and FC alterations, with more pronounced WMI changes in the TPAD group, predominantly within the left auxiliary basal or basomedial nucleus (AB/BM), right central nucleus, right lateral nuclei (dorsal portion), and left lateral nuclei (ventral portion containing basolateral portions). Moreover, the TPAD group exhibited decreased FC between the left AB/BM and left middle occipital gyrus and right superior frontal gyrus (SFG), left basal nucleus and right SFG, and right lateral nuclei (intermediate portion) and right SFG. In combination, these amygdalar alterations exhibited a sensitivity of 65.4% and specificity of 96.9% in predicting affective dysfunction in patients with tinnitus. Although similar structural and functional amygdala remodeling were observed in the TPAD and TPWAD groups, the changes were more pronounced in the TPAD group. These changes mainly involved alterations in functionality and white matter microstructure in various amygdala subregions; in combination, these changes could serve as an imaging‐based predictor of emotional disorders in patients with tinnitus.

show abstract

Section: Introductionmentioning

confidence: 99%