TiO₂-Templated BaTiO₃ Nanorod as a Piezocatalyst for Generating Wireless Cellular Stress

Abstract

Although the piezoelectric property of a BaTiO3 nanoparticle is routinely used in energy harvesting application, it can also be exploited for wireless cell stimulation and cell therapy. However, such biomedical application is rare due to limited availability of colloidal BaTiO3 nanoparticles of <100 nm hydrodynamic size with good piezocatalytic property and efficient biolabeling performance. Here, we report a colloidal form of a piezocatalytic BaTiO3-based nanorod of <100 nm hydrodynamic size that can offer wireless cell stimulation. The nanorod is prepared using a TiO2 nanorod as the template, and the resultant TiO2–BaTiO3-based composite nanorod is coated with a hydrophilic polymer shell. These nanorods can label cells and, under the ultrasound exposure, produce reactive oxygen species inside cells via piezocatalysis, leading to cell death. These nanorods can be used for wireless modulation of intracellular processes.

Chemically Designed Nanoscale Materials for Controlling Cellular Processes

“…68,69 Moreover, new-generation nanoparticles should be transformed into functional nanoparticles for wireless biomedical therapy. In particular, ultrasound-responsive piezocatalytic nanoparticles would be useful for controlling intracellular functions, 70 and anti-amyloidogenic nanodrugs may be designed for sonodynamic therapy of neuronal diseases. 71 Another potential hurdle would be to design <10 nm nanodrugs with the direct membrane penetration property.…”

“…In addition, we also need to consider the nonspecific adsorption issue of proteins around the nanoparticle, which may alter the physicochemical properties of designed nanodrugs. , Moreover, new-generation nanoparticles should be transformed into functional nanoparticles for wireless biomedical therapy. In particular, ultrasound-responsive piezocatalytic nanoparticles would be useful for controlling intracellular functions, and anti-amyloidogenic nanodrugs may be designed for sonodynamic therapy of neuronal diseases …”

2D Piezoelectric Bi2MoO6 Nanoribbons for GSH‐Enhanced Sonodynamic Therapy

“…This band bending reduced the distance between the band edge and the redox potentials of O 2 /·O 2 − (−0.33 V) and H 2 O/·OH (+2.10 V), thereby facilitating the separation of e − –h + and enabling energetic reactions e − /h + and O 2 /H 2 O to generate ROS. [ 26 ] In addition, the stability of GBMO NRs after US irradiation makes it a good candidate for piezoelectric sonosensitizer (Figure S9, Supporting Information).…”

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

“…Thus, for the improvement of release performance and achievement of better control, the special coating matrix design is often required [167,168] An alternative approach was proposed based on piezoelectric materials, where the appli cation of mechanical triggering led to bacterial degradation due to surface potential gen eration on the material surface [169,170]. The harvesting of mechanical energy and its con version to electro-chemical potential led to the production of ROS, ensuring bacterial cel disruption [171]. Such kind of material protection was demonstrated using the BaTiO material, which is known for its high piezoelectric coefficient, but recently was also re ported for polymer films with lower piezo-coefficient [172].…”