TiO2/APTES cross-linked to carboxylic graphene based impedimetric glucose biosensor

Ognjanović, Miloš; Stanković, Vesna; Knežević, Sara; Antić, Bratislav; Vranješ-Djurić, Sanja; Stanković, Dalibor M.

doi:10.1016/j.microc.2020.105150

Cited by 24 publications

(11 citation statements)

References 29 publications

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“…Ognjanovic et al deposited TiO 2 /APTES/carboxylic graphene (CG) Nanocomposites onto SPCE electrodes, by drop-casting method, for its application as a glucose biosensor [64]. They found that detecting the glucose level in a single drop of the actual sample is possible.…”

Section: Impedimetricmentioning

confidence: 99%

“…Alkylsilanes are the most widely used compounds in the preparation of monolayers on oxides due to the rapid formation of covalent bonds between the surfaces containing -OH groups and the silane anchoring groups [71]. (3-aminopropyl)triethoxysilane (APTES) is commonly used to obtain monolayers in TiO 2 surfaces ending in amines [72], which later allow the adhesion of antibodies [68], cell receptors [73] and carboxylic graphene surface [64]. Menori et al immobilized APTES on a TiO 2 film by immersing the film in a 2 M solution of APTES in toluene contained in a glass bottle under a N 2 atmosphere.…”

Section: Functionalization Of Tio 2 Surfaces With Biomoleculesmentioning

confidence: 99%

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Nanostructured Titanium Dioxide Surfaces for Electrochemical Biosensing

Bertel

Miranda

García-Martín

2021

Sensors

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TiO2 electrochemical biosensors represent an option for biomolecules recognition associated with diseases, food or environmental contaminants, drug interactions and related topics. The relevance of TiO2 biosensors is due to the high selectivity and sensitivity that can be achieved. The development of electrochemical biosensors based on nanostructured TiO2 surfaces requires knowing the signal extracted from them and its relationship with the properties of the transducer, such as the crystalline phase, the roughness and the morphology of the TiO2 nanostructures. Using relevant literature published in the last decade, an overview of TiO2 based biosensors is here provided. First, the principal fabrication methods of nanostructured TiO2 surfaces are presented and their properties are briefly described. Secondly, the different detection techniques and representative examples of their applications are provided. Finally, the functionalization strategies with biomolecules are discussed. This work could contribute as a reference for the design of electrochemical biosensors based on nanostructured TiO2 surfaces, considering the detection technique and the experimental electrochemical conditions needed for a specific analyte.

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Section: Impedimetricmentioning

confidence: 99%

Section: Functionalization Of Tio 2 Surfaces With Biomoleculesmentioning

confidence: 99%

Nanostructured Titanium Dioxide Surfaces for Electrochemical Biosensing

Bertel

Miranda

García-Martín

2021

Sensors

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“…The application of carbon or graphene-based nanomaterials especially in the field of electrochemical biosensors has become more intense the last decade [90] , [91] , [92] , [93] , [94] , since it is found that the nano-structuring of the transducer-electrode improves by far all their operation and efficiency features. For example, Chin et al [95] modifying the screen printed electrodes with carbon nanoparticles ascertained that the charge transfer kinetics is significantly enhanced, and so the biosensor current response was improved by 63%.…”

Section: Carbon and Graphene-based Sars-cov-2 Electrochemical Biosensorsmentioning

confidence: 99%

Emerging materials for the electrochemical detection of COVID-19

Balkourani

Brouzgou

Archonti

et al. 2021

Journal of Electroanalytical Chemistry

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“…Diabetes is determined when the glucose level is above 126 mg/dL in blood without having had a meal for 8 h. It can also be judged when the glucose level is above 200 mg/dL in blood 2 h after a meal [ 3 ]. Among different monitoring options, the electrochemical biosensor is widely used for glucose monitoring, and the electrochemical glucose sensor technology utilizes the glucose oxidase (GOx) enzyme and an electron transfer mediator such as p–benzoquinone, phenazine ethosulfate, lutetium phthalocyanine, or osmium [ 4 , 5 , 6 , 7 , 8 , 9 ]. Commercial blood glucose monitoring devices on the market mainly utilize a second-generation glucose sensor that consists of a metal mediator and GOx enzyme [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Glucose Sensor Based on Glucose Dehydrogenase Using Polydopamine-Functionalized Nanotubes

2021

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The electrochemical-based detection of glucose is widely used for diagnostic purposes and is mediated by enzyme-mediated signal transduction mechanisms. For such applications, recent attention has focused on utilizing the oxygen-insensitive glucose dehydrogenase (GDH) enzyme in place of the glucose oxidase (GOx) enzyme, which is sensitive to oxygen levels. Currently used Ru-based redox mediators mainly work with GOx, while Ru(dmo–bpy)2Cl2 has been proposed as a promising mediator that works with GDH. However, there remains an outstanding need to improve Ru(dmo–bpy)2Cl2 attachment to electrode surfaces. Herein, we report the use of polydopamine-functionalized multi-walled carbon nanotubes (PDA-MWCNTs) to effectively attach Ru(dmo–bpy)2Cl2 and GDH onto screen-printed carbon electrodes (SPCEs) without requiring a cross–linker. PDA-MWCNTs were characterized by Fourier transform infrared (FT–IR) spectroscopy, Raman spectroscopy, and thermal gravimetric analysis (TGA), while the fabrication and optimization of Ru(dmo–bpy)2Cl2/PDA-MWCNT/SPCEs were characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) measurements. The experimental results demonstrate a wide linear range of glucose-concentration-dependent responses and the multi-potential step (MPS) technique facilitated the selective detection of glucose in the presence of physiologically relevant interfering species, as well as in biological fluids (e.g., serum). The ease of device fabrication and high detection performance demonstrate a viable pathway to develop glucose sensors based on the GDH enzyme and Ru(dmo–bpy)2Cl2 redox mediator and the sensing strategy is potentially extendable to other bioanalytes as well.

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TiO2/APTES cross-linked to carboxylic graphene based impedimetric glucose biosensor

Cited by 24 publications

References 29 publications

Nanostructured Titanium Dioxide Surfaces for Electrochemical Biosensing

Nanostructured Titanium Dioxide Surfaces for Electrochemical Biosensing

Emerging materials for the electrochemical detection of COVID-19

Development of a Glucose Sensor Based on Glucose Dehydrogenase Using Polydopamine-Functionalized Nanotubes

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