TiO2-based nanosystem for cancer therapy and antimicrobial treatment: A review

Shi, Jinping; Li, Juan; Wang, Yan; Zhang, Can Yang

doi:10.1016/j.cej.2021.133714

Cited by 34 publications

(17 citation statements)

References 98 publications

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“…III) Recently, some studies ( 22 ) have shown that bacteria are becoming resistant to silver ions, which means that the antibacterial potency of silver ions/silver NPs is dropping. For TiO 2 NPs, it generally acts as a photocatalytic agent ( 23 , 24 ) to enhance the antibacterial efficacy. The penetration depth of UV-light or near-IR (NIR) still severely limits the application of the TiO 2 -based nanosystems.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-Based Zinc Ion Interference Therapy to Combat Bacterial Infections

Wei

Wang

et al. 2022

Front. Immunol.

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Pathogenic bacterial infections are the second highest cause of death worldwide and bring severe challenges to public healthcare. Antibiotic resistance makes it urgent to explore new antibacterial therapy. As an essential metal element in both humans and bacteria, zinc ions have various physiological and biochemical functions. They can stabilize the folded conformation of metalloproteins and participate in critical biochemical reactions, including DNA replication, transcription, translation, and signal transduction. Therefore, zinc deficiency would impair bacterial activity and inhibit the growth of bacteria. Interestingly, excess zinc ions also could cause oxidative stress to damage DNA, proteins, and lipids by inhibiting the function of respiratory enzymes to promote the formation of free radicals. Such dual characteristics endow zinc ions with unparalleled advantages in the direction of antibacterial therapy. Based on the fascinating features of zinc ions, nanomaterial-based zinc ion interference therapy emerges relying on the outstanding benefits of nanomaterials. Zinc ion interference therapy is divided into two classes: zinc overloading and zinc deprivation. In this review, we summarized the recent innovative zinc ion interference strategy for the treatment of bacterial infections and focused on analyzing the antibacterial mechanism of zinc overloading and zinc deprivation. Finally, we discuss the current limitations of zinc ion interference antibacterial therapy and put forward problems of clinical translation for zinc ion interference antibacterial therapy.

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Section: Introductionmentioning

confidence: 99%

Nanomaterial-Based Zinc Ion Interference Therapy to Combat Bacterial Infections

Wei

Wang

et al. 2022

Front. Immunol.

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“…Several studies have reported using TiO 2 -organic hybrid materials in different biomedical fields . A recent scientific trend is using the electrospinning technique to produce multimats with nano-TiO 2 NPs with an antibacterial activity which can be potentially applied in tissue engineering using in vitro approaches.…”

Section: Integration Of Pha-based Nanofibers With Antibacterial Agentsmentioning

confidence: 99%

Recent Development of Polyhydroxyalkanoates (PHA)-Based Materials for Antibacterial Applications: A Review

Ladhari

Boisvert

et al. 2023

ACS Appl. Bio Mater.

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The diseases caused by microorganisms are innumerable existing on this planet. Nevertheless, increasing antimicrobial resistance has become an urgent global challenge. Thus, in recent decades, bactericidal materials have been considered promising candidates to combat bacterial pathogens. Recently, polyhydroxyalkanoates (PHAs) have been used as green and biodegradable materials in various promising alternative applications, especially in healthcare for antiviral or antiviral purposes. However, it lacks a systematic review of the recent application of this emerging material for antibacterial applications. Therefore, the ultimate goal of this review is to provide a critical review of the state of the art recent development of PHA biopolymers in terms of cutting-edge production technologies as well as promising application fields. In addition, special attention was given to collecting scientific information on antibacterial agents that can potentially be incorporated into PHA materials for biological and durable antimicrobial protection. Furthermore, the current research gaps are declared, and future research perspectives are proposed to better understand the properties of these biopolymers as well as their possible applications.

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“…The preparation of NNHs by loading the bactericidal nanoparticles in the precursor solution begins with the mixed uniform solution, which is prepared into fibers by ESP. Mainstream bactericidal nanoparticles mainly include metal (AuNPs [135,136], AgNPs [137,138]) and metal oxides (ZnO [139], CuO [140] and TiO 2 [141]), etc. The accumulation of AgNPs in mitochondria leads to mitochondrial dysfunction.…”

Section: Antibacterialmentioning

confidence: 99%

“…Because of its unique physicochemical properties, where S is an important component of many amino acids in living organisms, MoS 2 is also an essential trace element in the human body [141]. Researchers found that doping MoS 2 , a two-dimensional material, with nanofibers can effectively promote cell proliferation and maintain cell viability of BMSCs, and at the same time, the higher the MoS 2 content, the stronger the osteogenic ability [161,162].…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…CaPs@GelMA-F cells we cultured with HUVECs cells, resulting in pictures of dense vascular network top CaPs@GelMA-F is also very effective in promoting angiogenesis [160]. Because of its unique physicochemical properties, where S is an important co nent of many amino acids in living organisms, MoS2 is also an essential trace elem the human body [141]. Researchers found that doping MoS2, a two-dimensional ma with nanofibers can effectively promote cell proliferation and maintain cell viabi BMSCs, and at the same time, the higher the MoS2 content, the stronger the osteo ability [161,162].…”

Section: Tissue Engineeringmentioning

confidence: 99%

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Electrospun Composite Nanofibers for Functional Applications

2022

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TiO2-based nanosystem for cancer therapy and antimicrobial treatment: A review

Cited by 34 publications

References 98 publications

Nanomaterial-Based Zinc Ion Interference Therapy to Combat Bacterial Infections

Nanomaterial-Based Zinc Ion Interference Therapy to Combat Bacterial Infections

Recent Development of Polyhydroxyalkanoates (PHA)-Based Materials for Antibacterial Applications: A Review

Electrospun Composite Nanofibers for Functional Applications

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