TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds

Novak, Saša; Druce, John; Chen, Qi Zhi; Boccaccını, Aldo R.

doi:10.1007/s10853-008-2858-9

Cited by 26 publications

(29 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, mechanical properties are major disadvantages of synthetic bioceramics and limit their use in load‐bearing applications (Huang, Wang, & Wang, ; Park, ). Improvement of the manufacturing processes, which eliminate structural flaws (Tiainen, Wiedmer, & Haugen, ) or improve microstructural features (Georgiou & Knowles, ; De Aza, Chevalier, Fantozzi, Schehl, & Torrecillas, ) or composite structures (Miao, Tan, Li, Xiao, & Crawford, ; Novak, Druce, Chen, & Boccaccini, ), is alternatives in improving the intrinsic strength of synthetic bioceramics. The most investigated CaP BG substitutes are hydroxyapatite, beta‐tricalcium phosphate and their combination, also called biphasic calcium phosphate (Dorati et al., ).…”

Section: Review Of Current Literaturementioning

confidence: 99%

Bone grafts: which is the ideal biomaterial?

Haugen

Lyngstadaas

Rossi

et al. 2019

J Clinic Periodontology

418

353

View full text Add to dashboard Cite

Bovine xenograft materials, followed by synthetic biomaterials, which unfortunately still lack documented predictability and clinical performance, dominate the market for the cranio‐maxillofacial area. In Europe, new stringent regulations are expected to further limit the allograft market in the future. Aim Within this narrative review, we discuss possible future biomaterials for bone replacement. Scientific Rationale for Study Although the bone graft (BG) literature is overflooded, only a handful of new BG substitutes are clinically available. Laboratory studies tend to focus on advanced production methods and novel biomaterial features, which can be costly to produce. Practical Implications In this review, we ask why such a limited number of BGs are clinically available when compared to extensive laboratory studies. We also discuss what features are needed for an ideal BG. Results We have identified the key properties of current bone substitutes and have provided important information to guide clinical decision‐making and generate new perspectives on bone substitutes. Our results indicated that different mechanical and biological properties are needed despite each having a broad spectrum of variations. Conclusions We foresee bone replacement composite materials with higher levels of bioactivity, providing an appropriate balance between bioabsorption and volume maintenance for achieving ideal bone remodelling.

show abstract

Section: Review Of Current Literaturementioning

confidence: 99%

Bone grafts: which is the ideal biomaterial?

Haugen

Lyngstadaas

Rossi

et al. 2019

J Clinic Periodontology

418

353

View full text Add to dashboard Cite

show abstract

“…169,170 Titanium composites show high compressive strength, improved densification and enhanced biocompatibility. Novak et al fabricated 171 TiO 2 foam-like scaffolds with pore size of the order of 300 nm with 95% porosity using the foam-replication method. PDLLA or PDLLA/Bioglass_coatings were developed to improve the structural integrity.…”

Section: Metallic Glassesmentioning

confidence: 99%

A review of bioactive glasses: Their structure, properties, fabrication and apatite formation

Kaur

Pandey

Singh

et al. 2013

J. Biomed. Mater. Res.

509

273

View full text Add to dashboard Cite

Bioactive glass and glass-ceramics are used in bone repair applications and are being developed for tissue engineering applications. Bioactive glasses/Bioglass are very attractive materials for producing scaffolds devoted to bone regeneration due to their versatile properties, which can be properly designed depending on their composition. An important feature of bioactive glasses, which enables them to work for applications in bone tissue engineering, is their ability to enhance revascularization, osteoblast adhesion, enzyme activity and differentiation of mesenchymal stem cells as well as osteoprogenitor cells. An extensive amount of research work has been carried out to develop silicate, borate/borosilicate bioactive glasses and phosphate glasses. Along with this, some metallic glasses have also been investigated for biomedical and technological applications in tissue engineering. Many trace elements have also been incorporated in the glass network to obtain the desired properties, which have beneficial effects on bone remodeling and/or associated angiogenesis. The motivation of this review is to provide an overview of the general requirements, composition, structure-property relationship with hydroxyapatite formation and future perspectives of bioglasses.Attention has also been given to developments of metallic glasses and doped bioglasses along with the techniques used for their fabrication.

show abstract

“…Scaffolds for TE must fulfill numerous requirements, including being biocompatible in bulk and degraded form, exhibiting suitable interconnected pore structure with pore size in the range 200‐400 μm (for bone TE) as well as sufficient mechanical properties and structural integrity . TiO 2 is one of the important bioceramics being considered to develop scaffolds for bone TE . These scaffolds show good mechanical strength, however they are “bioinert”, which limits their bone bonding ability and osteogenic effect .…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO₂ scaffolds and their drug releasing behavior

Sengottuvelan

Mederer

Boccaccını

2018

Int J Applied Ceramic Tech

Self Cite

View full text Add to dashboard Cite

Three dimensional titanium dioxide (TiO 2 ) scaffolds are receiving attention for the reconstruction of damaged bone tissue. Although these scaffolds show sufficient mechanical properties, their bioactivity is significantly lower than that of bioactive glass scaffolds. Sol-gel derived mesoporous bioactive glasses exhibit high bioactivity in vitro and can also be loaded with drugs and growth factors due to their tunable pore size. Hence, the main aim of this work is to produce and characterize TiO 2 scaffolds coated with sol-gel derived mesoporous calcium silicate spheres (MCS) and to test their in vitro bioactivity and drug delivery properties. TiO 2 scaffolds were coated with different wt% of MCS using a simple dip coating method. The bioactivity of the MCS-coated TiO 2 scaffolds was tested in vitro in simulated body fluid (SBF). TiO 2 scaffolds coated with 2 wt% and 4 wt% MCS showed bioactivity after 1 week of immersion in SBF. The formation of hydroxyapatite (HA) was confirmed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction analysis (XRD). Ibuprofen drug loading and release rate were investigated in MCS and MCS coated TiO 2 scaffolds. A 3 weeks in vitro drug release test was performed and the amount of drug released by MCS was measured by UV-Vis spectroscopy. The MCS were successfully loaded with Ibuprofen, as model drug. Sustained drug release was measured, proving the applicability of MCS as drug delivery carriers. Thus, TiO 2 scaffolds with enhanced functionalities were produced exploiting MCS coating. K E Y W O R D Sbioactivity, drug release, ibuprofen, mesoporous calcium silica coatings, scaffold, titania

show abstract

TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds

Cited by 26 publications

References 35 publications

Bone grafts: which is the ideal biomaterial?

Bone grafts: which is the ideal biomaterial?

A review of bioactive glasses: Their structure, properties, fabrication and apatite formation

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO₂ scaffolds and their drug releasing behavior

Contact Info

Product

Resources

About

TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds

Cited by 26 publications

References 35 publications

Bone grafts: which is the ideal biomaterial?

Bone grafts: which is the ideal biomaterial?

A review of bioactive glasses: Their structure, properties, fabrication and apatite formation

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO2 scaffolds and their drug releasing behavior

Contact Info

Product

Resources

About

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO₂ scaffolds and their drug releasing behavior