2008
DOI: 10.2217/17435889.3.5.627
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Tiopronin Monolayer-Protected Silver Nanoparticles Modulate IL-6 Secretion Mediated by Toll-Like Receptor Ligands

Abstract: Aims: Capped silver nanoparticles that can be coupled to a variety of molecules and biomolecules are of great interest owing to their potential applications in biomedicine. However, there are no data about their toxicity or functional effects on a key innate immune response, such as IL-6 secretion, after the engagement of the main group of pathogen-associated molecular patterns receptors, that is, the Toll-like receptors (TLRs). Materials & methods: N-(2-mercaptopropionyl)glycine (tiopronin)-capped silver … Show more

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Cited by 73 publications
(52 citation statements)
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“…As it has been reported, tiopronin silver nanoparticles (Castillo et al, 2008), BSA capped AgPt alloy nanoparticles (Singh et al, 2009) and silver nanoparticles protected with Na + -poly ( -glutamic acid) are not cytotoxic, while, by contrast bare silver nanoparticles have been found to be rather toxic (Braydich-Stolle et al, 2005;Kim et al, 2009;Hussain et al, 2005). This supports the idea that the toxicity is associated to the presence of bare metallic nanoparticle surfaces, while particles protected by and organic layer are much less toxic except starch capped nanoparticles which present mithocondrial dysfunction , induction of reactive oxygen species (ROS), DNA damage and cell cycle arrest (AshaRani et al, 2009).…”
Section: Cytotoxicity Biodistribution and Clearancementioning
confidence: 68%
See 1 more Smart Citation
“…As it has been reported, tiopronin silver nanoparticles (Castillo et al, 2008), BSA capped AgPt alloy nanoparticles (Singh et al, 2009) and silver nanoparticles protected with Na + -poly ( -glutamic acid) are not cytotoxic, while, by contrast bare silver nanoparticles have been found to be rather toxic (Braydich-Stolle et al, 2005;Kim et al, 2009;Hussain et al, 2005). This supports the idea that the toxicity is associated to the presence of bare metallic nanoparticle surfaces, while particles protected by and organic layer are much less toxic except starch capped nanoparticles which present mithocondrial dysfunction , induction of reactive oxygen species (ROS), DNA damage and cell cycle arrest (AshaRani et al, 2009).…”
Section: Cytotoxicity Biodistribution and Clearancementioning
confidence: 68%
“…This opens up new avenues in the world of adjuvants and illustrates the basic requirements for the design of NP conjugates that efficiently reach their target. It has recently been studied whether AgNPs with a narrow size distribution and protected with a monolayer of adsorbed tiopronin (Ag@tiopronin) had any functional impact on specific TLR stimulation of Interleukin-6 (IL-6) secretion in Raw 264.7 macrophages, a murine monocyte/macrophage cell line (Castillo et al, 2008), and the effects of silver nanoparticles on cytokine expression by peripheral blood mononuclear cells (PBMC) (Shin et al, 2007), human mesenchymal stem cells (hMSCs) (Greulich et al, 2009), and J774 A1 macrophages (Yen et al, 2009 The results demonstrated that Ag@tiopronin do not show proinflammatory effects on macrophages and that interestingly, Ag@tiopronins differentially inhibits the IL-6 secretion mediated by specific TLRs located in the cell surface or in the endocytic compartments (Castillo et al, 2008).…”
Section: Interaction Of Silver Nanoparticles With Key Signaling Pathwmentioning
confidence: 99%
“…Our observations were slightly different from previous surface-effect studies of silver NPs, which decreased TLR2 expression (Yilma et al, 2013). These differences may have resulted from the involvement of TLR2 in NP uptake, which altered TLR signaling pathways and then caused the regulation difference of TLR2 antigens (Castillo et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…(8) Silver nanoparticles can be easily incorporated in cotton fabric and dressings and have significantly decreased wound-healing time by an average of 3.35 days and increased bacterial clearance from infected wounds, with no adverse effects observed for the dressing. [48][49][50][51][52][53][54][55] (9) Anti-inflammatory properties of silver nanoparticles also promote wound healing by reducing cytokine release, 56 decreasing lymphocyte and mast cell infiltration. 57 …”
Section: Silver Nanoparticle Properties That Aid Wound Healingmentioning
confidence: 99%