TIPE1 promotes cervical cancer progression by repression of p53 acetylation and is associated with poor cervical cancer outcome

Zhao, Peiqing; Pang, Xiaoming; Jiang, Jie; Wang, Lianqing; Zhu, Xiaolan; Yin, Yingchun; Zhai, Qiaoli; Xiang, Xinxin; Fěng, Fang; Xu, Wenlin

doi:10.1093/carcin/bgy163

Cited by 34 publications

(35 citation statements)

References 29 publications

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“…Based on the results demonstrating altered TIPE1 expression in cancer tissues, the potential role of TIPE1 in predicting patient prognosis was also assessed in the present study. This has also been assessed in other types of cancer in previous studies ( 14 , 15 , 17 ). The results of the present study confirmed an inverse association between TIPE1 expression and poor prognosis in patients with ovarian cancer, which expands the role of TIPE1 in predicting prognosis in various types of cancer.…”

Section: Discussionmentioning

confidence: 98%

“…As an important regulator of homeostasis, the TIPE1 protein has been detected in a wide variety of normal tissues, including neurons, hepatocytes, muscular tissues and epithelial cells ( 23 ). Furthermore, several studies have demonstrated the dysregulation of TIPE1 in various types of cancer, including lung cancer ( 14 – 17 , 24 ). The majority of these studies have reported the downregulation of TIPE1 expression in cancer tissues and cells ( 14 – 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of these studies have reported the downregulation of TIPE1 expression in cancer tissues and cells ( 14 – 16 ). However, enhanced TIPE1 expression has been reported in cervical cancer tissues and cells ( 17 ). In the present study, TIPE1 expression was demonstrated to be downregulated in malignant tissues of patients with ovarian cancer and ovarian cancer cells, which was consistent with the results of previous studies on lung cancer ( 15 ), hepatocellular carcinoma ( 14 ) and gastric cancer ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Ye et al ( 26 ) reported that ectopic TIPE1 expression efficiently impairs stemness in colorectal cancer both in vitro and in vivo . TIPE1 also inhibits breast cancer cell proliferation, both in vivo and in vitro ( 27 ), whereas it serves as an oncogene in the pathogenesis of cervical cancer ( 17 ). Furthermore, TIPE1 overexpression effectively inhibits osteosarcoma tumor growth in vivo , which may contribute to the inhibition of macrophage infiltration in osteosarcoma ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

“…Downregulated TIPE1 expression has been observed in hepatocellular carcinoma ( 14 ), lung cancer ( 15 ) and gastric cancer ( 16 ). Ectopic TIPE1 expression promotes apoptosis and inhibits cell invasion and migration in several types of cancer ( 14 – 16 ); however, in cervical cancer, TIPE1 facilitates cell proliferation and suppresses the susceptibility of cells to cisplatin chemotherapy ( 17 ). Furthermore, ectopic TIPE1 expression significantly impairs osteosarcoma tumor growth in vivo by inhibiting macrophage infiltration ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

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TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

Deng

et al. 2020

Oncol Lett

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Tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) functions as a tumor suppressor in several types of cancer, including lung and breast cancer. The present study aimed to determine the level of expression and the function of TIPE1 in ovarian cancer. TIPE1 expression was determined in tissue microarrays and ovarian cancer cells, and these data were analyzed to assess the association between TIPE1 expression and prognosis in patients with ovarian cancer. The potential antitumor effects of TIPE1 were investigated in vitro and in a xenograft mouse model. Furthermore, the underlying molecular mechanism by which TIPE1 regulates ovarian cancer growth was determined via flow cytometric analysis, western blotting and rescue experiments. The results of the present study indicated that TIPE1 levels were markedly decreased in ovarian cancer tissues, and its level of expression was associated with a favorable prognosis of patients with ovarian cancer. In addition, ectopic TIPE1 expression significantly impaired A2780 and SKOV3 cell proliferation and colony formation in vitro , which was accompanied by efficient inhibition of xenograft tumor growth in mice. Investigations into the underlying molecular mechanism demonstrated that TIPE1 induced ovarian cancer cell apoptosis by promoting caspase protein expression. Inhibition of caspase-dependent apoptosis by z-VAD blocked TIPE1-mediated inhibition of the proliferation and induction of apoptosis in ovarian cancer cells. Collectively, the results of the present study suggest that TIPE1 may be a potential prognostic predictor and therapeutic target for patients with ovarian cancer.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

Deng

et al. 2020

Oncol Lett

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TNF‐α‐Induce Protein 8–Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal–Regulating Kinase 1

Zheng

et al. 2021

Hepatology

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Background and Aims Characterized by hepatocyte steatosis, inflammation, and fibrosis, NASH is a complicated process that contributes to end‐stage liver disease and, eventually, HCC. TNF‐α‐induced protein 8–like 1 (TIPE1), a new member of the TNF‐α‐induced protein 8 family, has been explored in immunology and oncology research; but little is known about its role in metabolic diseases. Approach and Results Here, we show that hepatocyte‐specific deletion of TIPE1 exacerbated diet‐induced hepatic steatosis, inflammation, and fibrosis as well as systemic metabolic disorders during NASH pathogenesis. Conversely, hepatocyte‐specific overexpression of TIPE1 dramatically prevented the progression of these abnormalities. Mechanically, TIPE1 directly interacted with apoptosis signal–regulating kinase 1 (ASK1) to suppress its TNF receptor–associated factor 6 (TRAF6)–catalyzed polyubiquitination activation upon metabolic challenge, thereby inhibiting the downstream c‐Jun N‐terminal kinase and p38 signaling pathway. Importantly, dramatically reduced TIPE1 expression was observed in the livers of patients with NAFLD, suggesting that TIPE1 might be a promising therapeutic target for NAFLD and related metabolic diseases. Conclusions TIPE1 protects against hepatic steatosis, inflammation, and fibrosis through directly binding ASK1 and restraining its TRAF6‐catalyzed polyubiquitination during the development of NASH. Therefore, targeting TIPE1 could be a promising therapeutic approach for NAFLD treatment.

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Hepatocellular Carcinoma

Mravec

2024

Neurobiology of Cancer

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TIPE1 promotes cervical cancer progression by repression of p53 acetylation and is associated with poor cervical cancer outcome

Cited by 34 publications

References 29 publications

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

TNF‐α‐Induce Protein 8–Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal–Regulating Kinase 1

Hepatocellular Carcinoma

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