Tirofiban combined with urokinase selective intra-arterial thrombolysis for the treatment of middle cerebral artery occlusion

Feng, Lei; Li, Jun; Liu, Yunzhen; Chen, Jian; Su, Chunhai; Lv, Chuanfeng; Wei, Yuzhen

doi:10.3892/etm.2016.2995

Cited by 8 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Behavioral tests can be performed on pigs, 31 dogs, 152 rabbits, 153 NHPs, 154 and sheep. 30 However, only a small proportion of the studies used behavioral endpoints (6%, 20/334; Figure 4(a)).…”

Section: Resultsmentioning

confidence: 99%

Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

Herrmann

Meckel

Gounis

et al. 2019

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far. Based on comprehensive research in two databases, this systematic review describes current large animal models in neuroendovascular research including their primary use. It may therefore serve as a compact compendium for researchers entering the field or looking for opportunities to refine study concepts. It also describes particular applications for ischemic stroke and aneurysm therapy, as well as for the treatment of arteriovenous malformations. It focuses on most promising study designs and readout parameters, as well as on important pitfalls in endovascular translational research including ways to circumvent them.

show abstract

Section: Resultsmentioning

confidence: 99%

Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

Herrmann

Meckel

Gounis

et al. 2019

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…If IAT was combined with other therapeutic strategies (e.g., mechanical thrombectomy, intravenous thrombolysis or tirofiban), the dosage could be reduced to 100,000-200,000 IU [24,25]. The dose of urokinase used in this study was less than that for IAT in large artery occlusion (mostly 500,000-1,000,000 IU) and more than that in combined therapies when it comes to the non-large artery occlusion.…”

Section: Discussionmentioning

confidence: 98%

Intra-Arterial Thrombolysis Improves the Prognosis of Acute Ischemic Stroke Patients without Large Vessel Occlusion

Shang

Zhao

et al. 2018

Eur Neurol

View full text Add to dashboard Cite

Background and Purpose: Intravenous thrombolysis is known as the only effective reperfusion therapy for acute ischemic stroke (AIS) caused by small branches occlusion. However, it is still unclear whether intra-arterial thrombolysis (IAT) is safe and effective for patients without detectable arterial occlusion. This study evaluated the safety and efficacy of IAT in these patients. Methods: Data were collected on consecutive patients from December 2012 to February 2017 at the Xuanwu Hospital, Capital Medical University. AIS patients without large artery occlusion during digital subtraction angiography (DSA) were divided into 2 groups: (1) Intra-arterial urokinase thrombolysis group (UK group): received intra-arterial urokinase thrombolysis treatment; (2) Control group: cerebral angiography examination only. The primary outcome was 3-month favorable functional outcome (modified Rankin Scale 0–2). Results: A total of 48 patients received urokinase thrombolysis, and 34 patients underwent DSA examination only. The UK group had more frequent favorable functional outcomes (70.8 vs. 50%, p = 0.032) at 3-month follow-up and higher score of National Institutes of Health Stroke Scale improvement on the second day (p = 0.007). One patient (2%) had symptomatic intracerebral hemorrhage and 3 patients (6.3%) had asymptomatic intracerebral hemorrhage (asICH) in the UK group. One patient (3.3%) had asICH in the control group. There were no significant differences about ICH. Conclusions: AIS caused by small branches occlusion could benefit from intra-arterial urokinase thrombolysis, and the risk of intracerebral hemorrhage was not significantly higher.

show abstract

“…Our case was only treated through the intra-arterial method, achieving a good result. Tirofiban is usually used as an addition to endovascular treatment, to prevent the reocclusion of the recanalized arteries [ 12 , 13 ]. Our observations indicate that the potential use of tirofiban as a thromblytic agent, and suggest further study to assess the role of intra-arterial tirofiban as a single treatment for acute ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Intra-arterial tirofiban in a male nonagenarian with acute ischemic stroke: A case report

Ding

Yang

et al. 2019

Open Life Sciences

View full text Add to dashboard Cite

Nonagenarians with acute ischemic stroke tend to have a higher mortality and morbidity than younger patients. Tirofiban is a glycoprotein IIb/IIIa antagonist that has a therapeutic potential for ischemic stroke. Here, we provide a case report of a 93-year-old male patient with acute ischemic stroke. He presented with right-sided hemiparesis for 2 hours (National Institute of Health Stroke Scale, NIHSS = 23). Immediate treatment with endovascular tirofiban infusion achieved an improvement of intracranial blood flow and a progressively decreased NIHSS one day after admission (NIHSS = 16) and then seven days after admission (NIHSS = 7). After a follow-up of 90 days, the modified ranking score was 2. This case report suggests that endovascular application with tirofiban may be a favorable option for treating nonagenarians presenting with acute ischemic stroke and warrants further study.

show abstract

Tirofiban combined with urokinase selective intra-arterial thrombolysis for the treatment of middle cerebral artery occlusion

Cited by 8 publications

References 25 publications

Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

Intra-Arterial Thrombolysis Improves the Prognosis of Acute Ischemic Stroke Patients without Large Vessel Occlusion

Intra-arterial tirofiban in a male nonagenarian with acute ischemic stroke: A case report

Contact Info

Product

Resources

About