Tirucallane-Type Triterpenoids from the Fruit of <i>Ficus carica</i> and Their Cytotoxic Activity

Abstract

Nine new tirucallane-type triterpenoids, ficutirucins A-I (1-9), were isolated from the fruit of Ficus carica. Their structures were established on the basis of spectroscopic data and chemical methods. All isolates were evaluated for their cytotoxic activities against three human cancer cell lines, MCF-7, HepG-2, and U2OS. Compounds 1-3, 6, 7, and 9 exhibited moderate cytotoxic activities with IC 50 values of 11.67-45.61 µM against one or more of the three cancer cell lines.

Extracts and components of <em>Ficus carica</em> leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells

“…Previous studies have shown that of fig fruit extracts exhibited moderate cytotoxic activities against MCF7, HepG2, and U2OS cells, 3 , 4 and fig latex has also shown inhibitory effects on proliferation of various cancer cell lines, eg, the Raji B-cell lymphoma stomach cancer line. 5 – 7 Little was known about the antiproliferation effect of the leaf decoction in cancer.…”

“…In agreement with our result, previous studies have found that fig leaves, fruit, and latex all contain anticancer components. 3 – 8 …”

“…Products of F. carica are widely used as food sources and medicine to treat various diseases. 1 For example, extract of fig fruit exerts hypotensive and antihypertensive effects in glucose-induced hypertensive rats 2 and exhibits moderate cytotoxic activities against human cancer cell lines, eg, MCF7, HepG2, and U2OS, 3 and exhibits antiproliferation against cervical cancer cell lines. 4 Leaf decoctions affect lipid catabolism in hypertriglyceridemic rats and had hypoglycemic action in type 1 diabetic patients, while fig latex also shows in vitro inhibitory effects on proliferation of various cancer cell lines.…”

Natural sources as promising future anticancer therapies - A review

“…Fagopyrum esculentum possessed anticancer effect against Hep G2 (hepatoma) cells, L1210 (leukemia) cells, breast cancer (MCF-7) cells, human mammary cancer cell Bcap37, human leukemia U937 cells, mammary tumor and colon tumors in rats (370)(371)(372)(373)(374)(375) . Ficus carica exerted antitumor activity against esophageal cancer line, breast cancer cell lines (MCF7), (Hep3b: Hepatocellular carcinoma; Hela: cervical epithelial cancer; PC-3: prostate cancer) cell lines, MCF-7, HepG-2, U2OS cell lines,T98G, U-138 MG,U-87 MG glioblastoma multiformecell lines and human melanoma cells (376)(377)(378)(379)(380)(381)(382)(383) . Ficus cunia protected from the formation of micronuclei cells induced by cyclophosphamide in bone marrow of mice (384) .…”