Tissierella Praeacuta Infection in the Setting of Chronic Sacral Wounds

Abstract

Tissierella praeacuta is a gram negative anaerobe with few documented cases of human infections. This case illustrates a patient who was admitted for infected chronic sacral and ischial decubitus wounds. BACT/ALERT blood culture system using Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) (Bruker Daltonics, Billerica, USA) was employed ultimately identifying Tissierella praeacuta as the causative organism. The suspected source of the pathogen was presumed to be from his infected decubitus wounds.

Tissierella praeacuta Bacteremia Associated With Acute on Chronic Osteomyelitis: A Case Report

“…T. praeacuta naturally occurs in anaerobic sludge, soil, and human microbiota. Of the five species under the Tissierella genus (T. praeacuta, T. creatinini, T.pigra, T. carlieri, and T. creatinophila), only T. praeacuta is reported to be pathogenic to humans [ 3 ]. A literature search of case reports using the terms "Tissierella praeacuta” or “Clostridium hastiforme” in the PubMed/MEDLINE database did not reveal any other cases of T. praeacuta infection in a patient with IVDU.…”

“…A literature search of case reports using the terms "Tissierella praeacuta” or “Clostridium hastiforme” in the PubMed/MEDLINE database did not reveal any other cases of T. praeacuta infection in a patient with IVDU. Tissierella bacteremia has been previously reported to co-infect patients with chronic infections such as calcaneal osteomyelitis in a diabetic patient [ 4 ] and sacral decubitus ulcer [ 3 ], successfully treated with beta-lactams. Other reported cases include knee arthroplasty, pyonephrosis with communicating liver abscess [ 5 ], brain abscess secondary to otitis media in a child [ 6 ], sepsis secondary to colon adenocarcinoma [ 7 ], eyelid gas gangrene [ 8 ], and pyometra secondary to an intrauterine device [ 9 ].…”

A Rare Case of Septic Ovarian Thrombophlebitis Caused by Tissierella praeacuta

“…Although classified as a Gram-positive organism, the cells of certain Tissierella species may stain Gram-negative or Gram variable [ 13 ], confounding appropriate empiric therapy. Identification can require matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) or 16S rRNA sequencing [ 14 ]. Neither was required in our case, but they could have accelerated identification and reduced our patient’s length of stay.…”